Title: Scientist, Downstream Process Development Location: Devens, MA - US Hybrid Full time Job Description: Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. Position Summary: The Scientist position will be part of the Biologics Downstream Development department in Devens, MA that is responsible for early and late stage process development of BMS' growing biologics pipeline. The candidate will be responsible for developing efficient, robust, and scalable purification processes for therapeutic biologics. The candidate will be working in a dynamic and collaborative team environment with opportunities to lead development and matrix teams, while enhancing our ever-growing biologics portfolio. Key Responsibilities: - Develop and implement scalable purification processes for biologics drugs to meet established timelines. - Design, execute and perform data analysis for downstream process development laboratory studies, including chromatography and filtration processes. - Organize and interpret results, present to matrix team and management. - Support process scale-up and tech transfer activities in pilot plant and clinical manufacturing sites - Support clinical manufacturing by reviewing documents and/or using technical expertise to ensure successful manufacturing campaigns. - Author electronic notebook records, process descriptions, process development reports, and other documentation/technical reports for progression of assets and/or support of regulatory filings. Qualifications & Experience: - PhD in Biotechnology, Protein Chemistry, Biochemistry or Chemical/Biochemical Engineering, with 0-2 years, or MS with 2- 4 years, or BS with 5-7 years of relevant industrial and/or academic experience preferred. - Knowledge of protein purification, protein stability, and demonstrated experimental skills for laboratory work are required. - Knowledge of protein characterization and analytical techniques is preferred. - Knowledge of statistical experimental design and data analysis is preferred. - Critical qualities include a high degree of initiative, good verbal and written communication skills, strong scientific skills and attention to detail, and the ability to work collaboratively in a team environment. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Devens - MA - US: $103,080 - $124,908 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: - Health Coverage: Medical, pharmacy, dental, and vision care. - Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). - Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work-life benefits include: Paid Time Off - US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) - Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. - Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. Supporting People with Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley. R1601773 : Scientist, Downstream Process Development

• Build and improve applied ML systems • Develop, evaluate, and improve models that help identify customer readiness • Use behavioral, conversational, operational, and CRM data to analyze performance and improve model quality • Define offline and online evaluation approaches, select metrics tied to business outcomes • Independently explore new models and enhancements to existing models • Work closely with product managers, engineers, and other scientists to refine problem statements

Title: Principal Scientist , Cancer Immunology Clinical Translational Research Location: Cambridge Crossing United States Job Description: Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. Position Summary: We are seeking an experienced immunologist with clinical translational experience to join the Translational Research team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, engaged, and creative scientist that can thrive in a highly matrixed organization to advance programs from candidate optimization through IND enabling activities and ultimately to Proof-of-Concept clinical trials. This individual will play a pivotal role in shaping and driving translational strategies for oncology assets, enabling the development of transformative cancer therapies for patients. Position Responsibilities: In the role as a Principal Scientist within Translational Research, the ideal candidate: - Serve as a key scientific stakeholder in early clinical trial programs. - Design and develop biomarker, pharmacodynamic, and target engagement assays to understand drug mechanism of action and response. - Interact with project teams and contract laboratories for the design, execution, and oversight of molecular, cellular, and/or in vivo studies. - Collaborate with cross-functional teams and external partners (CROs, specialty labs) to generate high-quality biomarker data for clinical studies. - Contribute to translational plans, sample collection strategies, and documentation for early-phase trials. - Present experimental results and share scientific insights with project teams and stakeholders. - Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles, as well as input around tumor types and potential impact of biomarkers on internal decision making. - Provides oversight to progress validated biomarkers into development of diagnostic assays, as needed - Participates in strategic review and input to presentations, publications and internal/ external communications along with accountable program leadership and in governance forums - Develops solutions and courses of action for senior staff, including identification of risks and risk mitigations - Shares expertise, experience, lessons learned and knowledge with translational and other relevant scientific experts and colleagues across the organization Experience = Basic Qualifications: - Bachelor's Degree - 8+ years of academic and / or industry experience Or - Master's Degree - 6+ years of academic and / or industry experience Or - Ph.D. or equivalent advanced degree in the Life Sciences - 4+ of academic and / or industry experience Preferred Qualifications: - PhD and 6+ years of industry experience in drug development, ideally with at least 3 years in clinical translational research or translational medicine. - Strong immunology experience, with an emphasis on solid tumor biology preferred. - Experience in oncology translational biomarker roles, with solid tumor and immune-oncology expertise strongly preferred. - Strong scientific acumen and mechanistic understanding of disease biology, with demonstrated contributions to oncology and immuno-oncology drug development. - Hands-on experience designing, executing, and analyzing translational biomarker assays and data across multiple technologies (e.g., genomics, immunohistochemistry, flow cytometry, immunoassays) and sample types in clinical studies. - Familiarity with the drug development process and experience collaborating with clinical teams; able to communicate results and contribute to discussions in cross-functional settings. - Demonstrated ability to work effectively with internal stakeholders and external partners (e.g., CROs, specialty labs). - Excellent communication, organizational, and teamwork skills, with a proactive and collaborative mindset. - Eagerness to learn, grow, and take on increasing responsibility in a fast-paced environment. #LI-Onsite If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Cambridge Crossing: $159,290 - $193,022 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: - Health Coverage: Medical, pharmacy, dental, and vision care. - Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). - Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work-life benefits include: Paid Time Off - US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) - Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. - Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. Supporting People with Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley. R1601947 : Principal Scientist, Cancer Immunology Clinical Translational Research

Role Description The Bioinformatics Scientist will take lab-generated data and create computational models that allow further manipulation and experimentation, perform incremental analysis required to process large amounts of data generated in a high-throughput Next Generation Sequencing (NGS) laboratory devoted to analysis of genomics data with focus on bulk and single-cell analysis. The function of Bioinformatics Scientist requires both strong programming skills and quantitative/statistical analysis. The successful candidate will thrive in a dynamic, fast-paced working environment and contribute directly to our company culture and success. Excellent verbal and written communication skills are required. You must be able to work in a team environment that values open and honest communication, embraces challenge, innovation and continuous improvement, works hard and loves to have fun, is fast-paced and displays a can-do attitude. If this is you and you can prove it, you could be a great fit for our team. A Day in the Life of a Bioinformatics Scientist at Discovery Life Sciences: - Work with Product Managers and Designers to conceptualize and implement new features. - Collaborate with fellow Engineers to architect robust and scalable software solutions. - Write clean, efficient, and maintainable code. - Participate in Agile development processes, including daily stand-ups and sprint planning meetings. Qualifications - Degree in Bioinformatics, Computational Biology or related field preferred. - Minimum of five (5) years' experience in next generation sequencing (NGS) (Illumina) data analysis. - Excellent programming skills, including Python and R, along with demonstrated experience with SQL databases, Unix and REST API. - Experience with Unix/Linux development environments and cloud computing. - Previous experience with bioinformatics tools such as BWA, SamTools, and GATK. - Ability to thrive in a dynamic, fast-paced working environment and contribute directly to our company culture and success. Requirements - Develops and employs computational tools to analyze biological data. - Interpret data such as gene or protein expression patterns nucleotide, and protein sequence, structure, functions, pathways, and genetic interactions. - Responsible for developing testing and supporting NGS data analysis tools and pipeline and ensuring proper automation of data analysis. - Evaluate and implement state-of-the-art methodologies for NGS data analysis. - Responsible for building scalable cloud and HPC solutions. - Create and maintain databases and data models for storage and retrieval of biological information. - Excellent verbal and written communication skills are required. - Collaborate with team members and stakeholders across the organization. Benefits - Competitive salary and benefits package options, including a free dental, vision package, life insurance, and disability coverage which start on your first day of employment. - This role is also eligible to earn performance-based incentive compensation, which may include cash bonus(es). These incentives are discretionary. - 401(k) match program which starts on your first day of employment. - Time away from work (Generous vacation and paid time off, paid parental leave, paid family leave, etc.). - Professional development opportunities and reimbursement for relevant certifications and tuition. - Collaborative and inclusive work environment that values diversity. - Team-building activities and social events. - Employee Referral Program and Colleague Recognition Program.