• Define technical solutions, technology stacks, and frameworks aligned with product requirements. • Ensure that technical decisions consider performance, security, scalability, and architectural sustainability. • Assess technical feasibility of requests before development begins. • Ensure current decisions do not generate excessive technical debt in the long term. • Establish and oversee development standards (Clean Code, SOLID, and engineering best practices). • Actively participate in code reviews and pull requests, ensuring adherence to the defined architecture. • Identify technical risks and propose mitigation strategies. • Contribute to continuous improvement of processes and delivery quality. • Act as the technical mentor for the development team. • Support junior, mid-level, and senior developers in resolving technical challenges. • Promote best practices and the technical growth of the team. • Foster team autonomy and professional growth. • Translate business needs into clear technical requirements for the engineering team. • Serve as the technical interlocutor in meetings with stakeholders and product teams. • Facilitate communication between technology and the business, removing impediments for the team.

About us: Shape the Future with AI, Ignite Your Potential Xenon7 is an inferno where skill, dedication and passion run together. About our client: Global healthcare leader headquartered in Indianapolis, Indiana. The Cardiometabolic Research (CMR) Therapeutic Area of our client, focuses on the discovery of biologic, small molecule and genetic therapeutics for the treatment of cardiometabolic diseases and associated complications.  We are seeking a highly motivated computational chemist to join our team and apply physics‑based modeling and cheminformatics to the design of chemically modified oligonucleotide therapeutics. Oligonucleotide therapeutics—including siRNAs, ASOs, and splice‑switching oligonucleotides—occupy a unique chemical space between small molecules and biologics. Each position in a therapeutic oligonucleotide can carry distinct sugar, backbone, and base modifications, creating a vast combinatorial design space that is poorly served by conventional computational chemistry tools. This role will bridge molecular simulation, cheminformatics, and machine learning to generate actionable insights that guide the optimization of chemically modified oligonucleotides across our client's RNA therapeutics portfolio. Key responsibilities include: - Perform molecular dynamics simulations of chemically modified oligonucleotide duplexes and single‑stranded species to characterize the structural and thermodynamic consequences of sugar, backbone, and base modifications - Apply free energy methods (FEP, thermodynamic integration, MM/PBSA, MM/GBSA) to predict modification‑dependent binding affinities, duplex stability, and protein–oligonucleotide interactions - Develop and validate force field parameters for novel nucleotide analogs using quantum mechanical calculations, enabling rapid computational evaluation of new chemistries emerging from the medicinal chemistry team - Build and apply cheminformatics descriptors and QSAR/QSPR models adapted for chemically modified oligonucleotides, moving beyond sequence‑only representations to capture the full chemical diversity of the modification space - Collaborate with medicinal chemists and biologists to integrate computational predictions with experimental SAR data, contributing to the identification of optimal modification patterns for on‑target potency, selectivity, metabolic stability, and safety - Contribute to reusable computational workflows, data assets, and modeling platforms that support cross‑program learning and integration with the team’s unified machine learning models - Present findings to cross‑functional teams and contribute to scientific strategy discussions, publications, and patent applications

Role Description We are seeking a highly motivated computational chemist to join our team and apply physics‑based modeling and cheminformatics to the design of chemically modified oligonucleotide therapeutics. Oligonucleotide therapeutics—including siRNAs, ASOs, and splice‑switching oligonucleotides—occupy a unique chemical space between small molecules and biologics. This role will bridge molecular simulation, cheminformatics, and machine learning to generate actionable insights that guide the optimization of chemically modified oligonucleotides across our client's RNA therapeutics portfolio. - Perform molecular dynamics simulations of chemically modified oligonucleotide duplexes and single‑stranded species to characterize the structural and thermodynamic consequences of sugar, backbone, and base modifications. - Apply free energy methods (FEP, thermodynamic integration, MM/PBSA, MM/GBSA) to predict modification‑dependent binding affinities, duplex stability, and protein–oligonucleotide interactions. - Develop and validate force field parameters for novel nucleotide analogs using quantum mechanical calculations, enabling rapid computational evaluation of new chemistries emerging from the medicinal chemistry team. - Build and apply cheminformatics descriptors and QSAR/QSPR models adapted for chemically modified oligonucleotides, moving beyond sequence‑only representations to capture the full chemical diversity of the modification space. - Collaborate with medicinal chemists and biologists to integrate computational predictions with experimental SAR data, contributing to the identification of optimal modification patterns for on‑target potency, selectivity, metabolic stability, and safety. - Contribute to reusable computational workflows, data assets, and modeling platforms that support cross‑program learning and integration with the team’s unified machine learning models. - Present findings to cross‑functional teams and contribute to scientific strategy discussions, publications, and patent applications. Qualifications - PhD in computational chemistry, physical chemistry, chemical physics, biophysics, or a closely related field. Requirements - Demonstrated expertise in molecular dynamics simulation of nucleic acids or chemically modified biopolymers. - Experience with free energy calculation methods applied to biomolecular systems. - Proficiency in cheminformatics toolkits (RDKit, OpenEye, or equivalent) and/or commercial CADD platforms (Schrödinger, MOE). - Strong programming skills in Python, with experience in scientific computing libraries. - Familiarity with machine learning and AI methods applied to molecular sciences, including experience with predictive modeling for molecular properties, chemical optimization, or structure–activity relationships. - Excellent written and oral communication skills with ability to present complex computational results to diverse scientific audiences including medicinal chemists and biologists. - Experience with high‑performance computing and/or cloud‑based simulation environments. - Demonstrated ability to work collaboratively in cross‑functional team environments. - Experience with force field parameterization for non‑standard nucleotide analogs, including QM‑derived charge fitting (RESP, AM1‑BCC) and torsion parameter development. - Familiarity with quantum chemical methods (DFT, ab initio) for electronic structure analysis of modified nucleotides and their impact on duplex stability and reactivity. - Understanding of how chemical modifications influence oligonucleotide secondary structure, folding, and conformational dynamics, including modification‑dependent effects on duplex geometry and protein recognition. - Experience with machine learning approaches for molecular property prediction, including graph neural networks, molecular language models, or transformer‑based architectures applied to chemical or biopolymer data. - Familiarity with molecular representations for modified oligonucleotides (HELM, extended SMILES, or similar macromolecular encoding schemes). - Knowledge of oligonucleotide‑specific ADME properties, including nuclease‑mediated metabolism, plasma protein binding of phosphorothioate backbones, and endosomal escape. - Track record of peer‑reviewed publications demonstrating expertise in computational chemistry applied to nucleic acids or modified biopolymers. - Deep understanding of nucleic acid structure and chemistry, including familiarity with common therapeutic modifications (2’‑OMe, 2’‑F, 2’‑MOE, LNA/cET, phosphorothioate, GalNAc conjugates). - Experience designing computational workflows that integrate with automated experimental platforms and high‑throughput screening. - Proficiency in Rust or other systems‑level languages for performance‑critical scientific computing is a plus.

About us: Shape the Future with AI, Ignite Your Potential Xenon7 is an inferno where skill, dedication and passion run together. About our client: Global healthcare leader headquartered in Indianapolis, Indiana. The Cardiometabolic Research (CMR) Therapeutic Area of our client, focuses on the discovery of biologic, small molecule and genetic therapeutics for the treatment of cardiometabolic diseases and associated complications.  We are seeking a highly motivated computational chemist to join our team and apply physics‑based modeling and cheminformatics to the design of chemically modified oligonucleotide therapeutics. Oligonucleotide therapeutics—including siRNAs, ASOs, and splice‑switching oligonucleotides—occupy a unique chemical space between small molecules and biologics. Each position in a therapeutic oligonucleotide can carry distinct sugar, backbone, and base modifications, creating a vast combinatorial design space that is poorly served by conventional computational chemistry tools. This role will bridge molecular simulation, cheminformatics, and machine learning to generate actionable insights that guide the optimization of chemically modified oligonucleotides across our client's RNA therapeutics portfolio. Key responsibilities include: - Perform molecular dynamics simulations of chemically modified oligonucleotide duplexes and single‑stranded species to characterize the structural and thermodynamic consequences of sugar, backbone, and base modifications - Apply free energy methods (FEP, thermodynamic integration, MM/PBSA, MM/GBSA) to predict modification‑dependent binding affinities, duplex stability, and protein–oligonucleotide interactions - Develop and validate force field parameters for novel nucleotide analogs using quantum mechanical calculations, enabling rapid computational evaluation of new chemistries emerging from the medicinal chemistry team - Build and apply cheminformatics descriptors and QSAR/QSPR models adapted for chemically modified oligonucleotides, moving beyond sequence‑only representations to capture the full chemical diversity of the modification space - Collaborate with medicinal chemists and biologists to integrate computational predictions with experimental SAR data, contributing to the identification of optimal modification patterns for on‑target potency, selectivity, metabolic stability, and safety - Contribute to reusable computational workflows, data assets, and modeling platforms that support cross‑program learning and integration with the team’s unified machine learning models - Present findings to cross‑functional teams and contribute to scientific strategy discussions, publications, and patent applications