Mineralys Therapeutics

Role Description The Territory Manager will play a critical role in the successful launch and growth of Mineralys’ first commercial product within an assigned territory. This individual will be responsible for: - Educating healthcare providers (HCPs) on Mineralys’ product. - Building trusted customer relationships. - Driving product adoption. - Achieving territory sales performance goals. This is a highly visible role requiring strong selling skills, customer engagement capabilities, and a passion for improving outcomes for patients with uncontrolled hypertension. The ideal candidate thrives in a fast-paced, entrepreneurial biotech environment and is energized by the opportunity to launch a breakthrough new class of medicine. Key Responsibilities - Territory Management / Business Execution - Develop and maintain a strong understanding of the disease state, clinical data, and relevant treatment guidelines. - Build and execute a comprehensive territory business plan aligned with brand strategy, launch priorities, and sales objectives. - Drive product adoption and compliant utilization among targeted healthcare providers. - Analyze territory trends, customer needs, and competitive activity to identify opportunities and course correct as needed. - Consistently deliver against sales goals, call activity expectations, and launch milestones. - Maintain accurate territory reporting and CRM documentation. - Customer Engagement / Selling Excellence - Execute strategic call plans by translating data and insights into impactful, customer-focused actions. - Demonstrate curiosity, adaptability, and openness to new ideas, embracing innovative approaches to customer engagement. - Apply strong business acumen to assess market dynamics and leverage insights for effective territory planning. - Build and sustain trusted relationships with healthcare providers, office staff, and key decision-makers. - Clearly and compliantly communicate clinical data, product value, access information, and appropriate patient identification. - Deliver engaging, high-quality product presentations and address customers' questions with confidence and credibility. - Partner with customers to address barriers to patient access and support product pull-through. - Cross-Functional Collaboration - Partner effectively with cross-functional stakeholders to understand customers' needs and elevate the overall customer and patient experience in a compliant manner. - Collaborate closely with adjacent field partners including Field Reimbursement Managers, Territory Managers, and Regional Business Directors to support customer needs and territory objectives. - Share insights, learnings, and best practices with field leadership and internal team (e.g., Marketing, Training, Field Operations and Analytics). - Provide timely market intelligence, customer insights, and competitive updates. - Support regional meetings, launch initiatives, and company-sponsored programs. - Compliance / Culture - Operate with the highest standards of integrity and in full compliance with all company policies, industry regulations, and legal requirements. - Demonstrate professionalism, accountability, and ethical conduct in all customer interactions. - Consistently embody Mineralys’ values of collaboration, integrity, quality, trust, and urgency. Qualifications - Bachelor’s degree required. - 3+ years of pharmaceutical/biotech sales experience preferred with other relevant sales experience considered. - Specialty sales experience (cardiometabolic) preferred. - Prior launch experience preferred. - Proven track record of achieving or exceeding sales goals and strong customer relationships. - Strong clinical acumen and ability to communicate complex scientific information. - Excellent territory planning, organizational, and communication skills. - Self-motivated, entrepreneurial mindset with the ability to thrive in a fast-paced, launch environment. - Valid driver’s license and willingness to travel within territory. Success Profile - Customer-focused, centric, and relationship-driven. - Highly accountable with strong execution focus. - Adaptable and resilient in a launch environment. - Collaborative, team-oriented, and eager to contribute to shared success. - Passionate about making a meaningful impact for patients. Travel This position requires up to 60% travel. Benefits - Standard Company benefits including medical, dental, vision, time off, and 401K. - Participation in Mineralys incentive plans contingent on achievement of personal and company performance. - Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. - US Salary Range: $130,000 - $165,000.

Senior Medical Science Liaisons(MSL) - Cardiovascular, Detroit Region US Remote “Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky” Mineralys is a fully remote company. Our Medical Affairs team is growing and hiring Senior Medical Science Liaison's across the US! Focusing on the Detroit, Michigan region. These field-based medical experts will support the US Medical Affairs team and will focus on establishing, developing, and maintaining strong collaborative relationships through scientific engagement with Key Opinion Leaders and Healthcare Practitioners within the assigned territory. This field position requires a strong background in the pharmaceutical industry, understanding the complexities of healthcare systems, and requires experience in an MSL or MSL like role in cardiovascular disease. - Build and maintain relationships with key opinion leaders (KOLs) and healthcare professionals within assigned region - Primary point of contact for field medical and scientific inquiries - Serve as subject matter expert at key medical and scientific conferences, advisory boards, roundtables, clinical investigator meetings, speaker training, and internal meetings - Lead and/or participate in project teams that support MSL strategies and tactics as delegated by MSL leadership - Identify and engage with healthcare stakeholders to educate and communicate clinical and scientific data, outcomes, and economic data to providers - Deliver scientific presentations and training to diverse HCP audiences with the ability to summarize and communicate complex scientific information in an effective manner - Serve as a strategic partner with internal cross-functional teams - Support clinical trial site activities as needed and identify/ advocate for opportunities in investigator sponsored trial research - Support continuing medical education (CME) requests and activities through unsolicited grants process - Support field medical congress activities, and attend national, regional, and local meetings and medical congresses where appropriate to gather competitive intelligence, develop productive medical collaborations, and attend and report on educational sessions - Gather, analyze, and communicate actionable insights from the field to inform company strategy, clinical challenges, and patient management trends - Participate and contribute in cross-functional meetings, ensuring insights from the field are shared and discussed with Medical Affairs, R&D, Commercial, and other key internal stakeholders - Ensure policies, procedures, and guidance are adhered to and Perform all Company business in accordance with all regulations (e.g. EEO FDA, OSHA, PDMA, EPA PhRMA, etc.) - Contribute to medical affairs metrics, qualitative and quantitative MSL reports and SOPs for the MSL function. Document all field activities in accordance with company policies and regulatory requirements, ensuring compliance with industry standards Requirements: - Pharm.D., Ph.D., M.D. or D.O. (other doctoral degrees considered) - For a Senior MSL level we require 5+ years of current MSL experience, and 3 to 5 years of current MSL experience for a Medical Science Liaison in Scientific/Medical Affairs at a biotech or pharmaceutical company - Cardiology/Renal/Metabolic experience preferred. - 5+ years focused on clinical practice, clinical research, or medical research a plus - Experience in a medically related field can include post-doctoral training (i.e., residences and/or fellowships) - Experience with all phases of KOL development and HCP engagement with experience with drug launches - Skilled in driving cross-functional collaboration, delivering high-quality scientific insights, and consistently achieving measurable outcomes aligned with corporate goals. - Strong interpersonal skills including excellent verbal and written communication and peer-to-peer professional collaborations Must be located within driving distance of a major international airport; approx. 50 - 70% travel. Valid US driver’s license required, ability to travel without restrictions. These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $190,000 - $225,000 #LI-Remote

Senior Medical Science Liaisons (MSL)Cardiovascular - Los Angeles, California Region US Remote “Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. Mineralys is a fully remote company. Our Medical Affairs team is growing and hiring Senior Medical Science Liaison's across the US! Focusing on the Los Angeles Region These field-based medical experts will support the US Medical Affairs team and will focus on establishing, developing, and maintaining strong collaborative relationships through scientific engagement with Key Opinion Leaders and Healthcare Practitioners within the assigned territory. This field position requires a strong background in the pharmaceutical industry, understanding the complexities of healthcare systems, and requires experience in an MSL or MSL like role in cardiovascular disease. - Build and maintain relationships with key opinion leaders (KOLs) and healthcare professionals within assigned region - Primary point of contact for field medical and scientific inquiries - Serve as subject matter expert at key medical and scientific conferences, advisory boards, roundtables, clinical investigator meetings, speaker training, and internal meetings - Lead and/or participate in project teams that support MSL strategies and tactics as delegated by MSL leadership - Identify and engage with healthcare stakeholders to educate and communicate clinical and scientific data, outcomes, and economic data to providers - Deliver scientific presentations and training to diverse HCP audiences with the ability to summarize and communicate complex scientific information in an effective manner - Serve as a strategic partner with internal cross-functional teams - Support clinical trial site activities as needed and identify/ advocate for opportunities in investigator sponsored trial research - Support continuing medical education (CME) requests and activities through unsolicited grants process - Support field medical congress activities, and attend national, regional, and local meetings and medical congresses where appropriate to gather competitive intelligence, develop productive medical collaborations, and attend and report on educational sessions - Gather, analyze, and communicate actionable insights from the field to inform company strategy, clinical challenges, and patient management trends - Participate and contribute in cross-functional meetings, ensuring insights from the field are shared and discussed with Medical Affairs, R&D, Commercial, and other key internal stakeholders - Ensure policies, procedures, and guidance are adhered to and Perform all Company business in accordance with all regulations (e.g. EEO FDA, OSHA, PDMA, EPA PhRMA, etc.) - Contribute to medical affairs metrics, qualitative and quantitative MSL reports and SOPs for the MSL function. Document all field activities in accordance with company policies and regulatory requirements, ensuring compliance with industry standards Requirements: - Pharm.D., Ph.D., M.D. or D.O. (other doctoral degrees considered) - For a Senior MSL level we require 5+ years of current MSL experience, and 3 to 5 years of current MSL experience for a Medical Science Liaison in Scientific/Medical Affairs at a biotech or pharmaceutical company - Cardiology/Renal/Metabolic experience preferred. - 5+ years focused on clinical practice, clinical research, or medical research a plus - Experience in a medically related field can include post-doctoral training (i.e., residences and/or fellowships) - Experience with all phases of KOL development and HCP engagement with experience with drug launches - Skilled in driving cross-functional collaboration, delivering high-quality scientific insights, and consistently achieving measurable outcomes aligned with corporate goals. - Strong interpersonal skills including excellent verbal and written communication and peer-to-peer professional collaborations Must be located within driving distance of a major international airport; approx. 50 - 70% travel. Valid US driver’s license required, ability to travel without restrictions. These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $190,000 - $225,000 #LI-Remote

Title: Senior Medical Science Liaisons (MSL) - Cardiovascular, Tennessee/ Kentucky Location: US Remote Our Medical Affairs team is growing and hiring Senior Medical Science Liaison's and Medical Science Liaison's across the US! Focusing on the Tennessee Region (Knoxville, Memphis) and Kentucky (Louisville, Lexington) regions. These field-based medical experts will support the US Medical Affairs team and will focus on establishing, developing, and maintaining strong collaborative relationships through scientific engagement with Key Opinion Leaders and Healthcare Practitioners within the assigned territory. This field position requires a strong background in the pharmaceutical industry, understanding the complexities of healthcare systems, and requires experience in an MSL or MSL like role in cardiovascular disease. - Build and maintain relationships with key opinion leaders (KOLs) and healthcare professionals within assigned region - Primary point of contact for field medical and scientific inquiries - Serve as subject matter expert at key medical and scientific conferences, advisory boards, roundtables, clinical investigator meetings, speaker training, and internal meetings - Lead and/or participate in project teams that support MSL strategies and tactics as delegated by MSL leadership - Identify and engage with healthcare stakeholders to educate and communicate clinical and scientific data, outcomes, and economic data to providers - Deliver scientific presentations and training to diverse HCP audiences with the ability to summarize and communicate complex scientific information in an effective manner - Serve as a strategic partner with internal cross-functional teams - Support clinical trial site activities as needed and identify/ advocate for opportunities in investigator sponsored trial research - Support continuing medical education (CME) requests and activities through unsolicited grants process - Support field medical congress activities, and attend national, regional, and local meetings and medical congresses where appropriate to gather competitive intelligence, develop productive medical collaborations, and attend and report on educational sessions - Gather, analyze, and communicate actionable insights from the field to inform company strategy, clinical challenges, and patient management trends - Participate and contribute in cross-functional meetings, ensuring insights from the field are shared and discussed with Medical Affairs, R&D, Commercial, and other key internal stakeholders - Ensure policies, procedures, and guidance are adhered to and Perform all Company business in accordance with all regulations (e.g. EEO FDA, OSHA, PDMA, EPA PhRMA, etc.) - Contribute to medical affairs metrics, qualitative and quantitative MSL reports and SOPs for the MSL function. Document all field activities in accordance with company policies and regulatory requirements, ensuring compliance with industry standards Requirements: - Pharm.D., Ph.D., M.D. or D.O. (other doctoral degrees considered) - For a Senior MSL level we require 5+ years of current MSL experience, and 3 to 5 years of current MSL experience for a Medical Science Liaison in Scientific/Medical Affairs at a biotech or pharmaceutical company - Cardiology/Renal/Metabolic experience preferred. - 5+ years focused on clinical practice, clinical research, or medical research a plus - Experience in a medically related field can include post-doctoral training (i.e., residences and/or fellowships) - Experience with all phases of KOL development and HCP engagement with experience with drug launches - Skilled in driving cross-functional collaboration, delivering high-quality scientific insights, and consistently achieving measurable outcomes aligned with corporate goals. - Strong interpersonal skills including excellent verbal and written communication and peer-to-peer professional collaborations Must be located within driving distance of a major international airport; approx. 50 - 70% travel. Valid US driver’s license required, ability to travel without restrictions. These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $190,000 - $225,000

Role Description Mineralys is seeking an experienced marketing leader who is energized by the opportunity to build from the ground up, establish foundational capabilities, and shape the promotional medical education strategy for a best‑in‑class launch. Reporting to the Sr. Director, HCP Marketing, the Director, HCP Marketing will be responsible for translating HCP brand strategy into high‑impact launch execution to drive awareness, engagement, and adoption. This role shapes and executes launch strategy by connecting data to insight, refining messaging, and driving effective field activation and omnichannel execution. This role requires both strategic and hands-on executional leadership. The ideal candidate will be a self-starter with deep experience in HCP marketing, including: - Launch planning - Messaging - Creative campaign development - Tactical execution - Cross-functional leadership Previous launch and cardiovascular and/or chronic care experience is strongly preferred. Qualifications - MBA or bachelor’s degree plus 8+ years of pharmaceutical or biotech industry experience including 6+ years in HCP marketing - Demonstrated launch experience - Cardiovascular and/or chronic care experience is highly preferred - A builder mindset with high personal accountability, resourcefulness, and a collaborative spirit - Proven ability to lead through ambiguity and define direction - Experience effectively leading cross-functional teams and agency partners - Excellent communication and presentation skills Requirements - Lead the development and execution of HCP brand strategy grounded in deep understanding of clinical data, existing standards of care, treatment guidelines, and competitive dynamics - Partner with market research to identify and translate strategic insights including segmentation, decision drivers, and prescribing behaviors into launch readiness plans and prioritized HCP engagement tactics - Lead development and execution of messaging, creative campaign, tactical development, including personal and non-personal channels - Partner closely with the Patient & Consumer Marketing lead and Digital team to deliver aligned omnichannel strategy and integrated activation across HCP, patient, and digital touchpoints - Actively partner with Sales, Sales Training, and Commercial Operations to develop and optimize field force training and initiatives - Lead sample strategy as part of the HCP launch plan, partnering cross‑functionally to ensure compliant execution and field pull‑through - Work closely with Medical, Legal, Regulatory, and Compliance to ensure compliant and aligned messaging and execution - Collaborate closely with Medical Affairs to integrate clinical data and real-world experience into HCP brand strategy and ensure aligned evidence generation planning - Evaluate the effectiveness of promotional strategies through campaign measurement and metrics development to ensure positive return on investment and achievement of brand objectives - Develop and manage relationships with external vendors and agency partners Benefits - US Salary Range: $200,000 - $220,000 - Fully remote company

Role Description Mineralys is a fully remote company. Our Medical Affairs team is growing and hiring Senior Medical Science Liaison's and Medical Science Liaison's across the US! These field-based medical experts will support the US Medical Affairs team and will focus on establishing, developing, and maintaining strong collaborative relationships through scientific engagement with Key Opinion Leaders and Healthcare Practitioners within the assigned territory. This field position requires a strong background in the pharmaceutical industry, understanding the complexities of healthcare systems, and requires experience in an MSL or MSL-like role in cardiovascular disease. - Build and maintain relationships with key opinion leaders (KOLs) and healthcare professionals within assigned region. - Primary point of contact for field medical and scientific inquiries. - Serve as subject matter expert at key medical and scientific conferences, advisory boards, roundtables, clinical investigator meetings, speaker training, and internal meetings. - Lead and/or participate in project teams that support MSL strategies and tactics as delegated by MSL leadership. - Identify and engage with healthcare stakeholders to educate and communicate clinical and scientific data, outcomes, and economic data to providers. - Deliver scientific presentations and training to diverse HCP audiences with the ability to summarize and communicate complex scientific information in an effective manner. - Serve as a strategic partner with internal cross-functional teams. - Support clinical trial site activities as needed and identify/advocate for opportunities in investigator sponsored trial research. - Support continuing medical education (CME) requests and activities through unsolicited grants process. - Support field medical congress activities, and attend national, regional, and local meetings and medical congresses where appropriate to gather competitive intelligence, develop productive medical collaborations, and attend and report on educational sessions. - Gather, analyze, and communicate actionable insights from the field to inform company strategy, clinical challenges, and patient management trends. - Participate and contribute in cross-functional meetings, ensuring insights from the field are shared and discussed with Medical Affairs, R&D, Commercial, and other key internal stakeholders. - Ensure policies, procedures, and guidance are adhered to and perform all Company business in accordance with all regulations (e.g. EEO FDA, OSHA, PDMA, EPA PhRMA, etc.). - Contribute to medical affairs metrics, qualitative and quantitative MSL reports and SOPs for the MSL function. Document all field activities in accordance with company policies and regulatory requirements, ensuring compliance with industry standards. Qualifications - Pharm.D., Ph.D., M.D. or D.O. (other doctoral degrees considered). - For a Senior MSL level, we require 5+ years of current MSL experience, and 3 to 5 years of current MSL experience for a Medical Science Liaison in Scientific/Medical Affairs at a biotech or pharmaceutical company. - Cardiology/Renal/Metabolic experience preferred. - 5+ years focused on clinical practice, clinical research, or medical research a plus. - Experience in a medically related field can include post-doctoral training (i.e., residences and/or fellowships). - Experience with all phases of KOL development and HCP engagement with experience with drug launches. - Skilled in driving cross-functional collaboration, delivering high-quality scientific insights, and consistently achieving measurable outcomes aligned with corporate goals. - Strong interpersonal skills including excellent verbal and written communication and peer-to-peer professional collaborations. - Must be located within driving distance of a major international airport; approx. 50 - 70% travel. Valid US driver’s license required, ability to travel without restrictions. Requirements - These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. - Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. - US Salary Range: $190,000 - $225,000.

Title: Regional Sales Director - San Diego Location: US Remote Job Description: “Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. Mineralys is a fully remote company. Regional Sales Director The Regional Sales Director (RSD) will play a critical role in the successful launch and growth of Mineralys’ first commercial product within an assigned region. This leader will be accountable for translating national strategy into regional execution, driving business performance through strong field leadership, cross-functional partnership, and disciplined execution against launch objectives. The RSD will build and lead a high-performing team of territory managers, foster deep customer relationships, and ensure alignment with corporate priorities, compliance standards, and Mineralys’ values. This is a highly visible field leadership role requiring strong business acumen, launch experience, and the ability to lead with urgency in a fast-paced, entrepreneurial environment. The RSD will cover a Territory including: - San Diego, CA - Southwest Phoenix, AZ - Las Vegas, NV Key Responsibilities Commercial Leadership / Launch Execution - Lead all regional launch planning and execution activities to ensure successful market entry and sustained product uptake - Translate national brand strategy into actionable regional business plans and field execution priorities - Lead team to achieve or exceed sales goals, market share targets, and key performance metrics at launch and beyond - Monitor market dynamics, customer feedback, and competitive intelligence to adjust strategy in real time - Drive accountability for performance through data-driven decision making and disciplined execution Team Leadership / Coaching - Recruit, onboard, develop, and retain top-performing territory managers across the region - Lead, coach, and motivate a team of approximately 8–12 territory managers - Establish and maintain high level of disease state, clinical and product knowledge - Evaluate performance of territory managers and coach to skill and career development through regular field contact - Foster a high-performance culture focused on accountability, collaboration, and continuous improvement - Build strong succession plans and talent pipelines Customer / Market Engagement - Develop and maintain relationships with key healthcare providers, health systems, integrated delivery networks (IDNs) and strategic accounts - Partner with territory managers on key customer interactions, access challenges, and develop account strategies - Support pull-through with IDNs, organized customers, and priority accounts - timely and effectively sharing of customer insights with internal stakeholders Cross-Functional Collaboration - Partner closely with Market Access, Marketing, Medical Affairs, Training, Operations, and HR to support launch readiness and execution - Provide field-driven input into brand planning, messaging, and tactical adjustments - Collaborate with Area Sales Directors and peers to share best practices and drive consistency across regions - Support national meetings, launch planning sessions, and field communications Compliance / Operational Excellence - Ensure all regional activities are conducted in full compliance with company policies, industry regulations, and legal standards - Manage regional budgets and resources effectively - Maintain accurate forecasting, CRM utilization, and reporting discipline - Uphold Mineralys’ values of collaboration, integrity, quality, trust, and urgency Qualifications - Bachelor’s degree required; advanced degree preferred - 8+ years of pharmaceutical / biotech sales experience - 3+ years of people leadership experience in a district / regional manager role - Proven success leading specialty sales teams and exceeding performance goals - Prior launch experience required; first-launch / startup biotech experience strongly preferred - Experience in cardiovascular, nephrology, hypertension, or related specialty markets strongly preferred - Demonstrated success in recruiting and developing top talent - Strong business planning, analytical, and coaching skills - Ability to work effectively in a fast-paced, highly collaborative environment - Willingness to travel extensively within region Leadership Profile - A strong coach who develops people and builds winning teams - Highly accountable, with a bias for action and urgency - Comfortable operating in ambiguity and helping build infrastructure - Collaborative and able to influence across functions - Resilient, adaptable, and energized by launch environments Travel - This position requires up to 60% travel. Frequently travel is outside the local area and overnight. These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $180,000 - $215,000 #LI-REMOTE

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky” Mineralys is a fully remote company. Associate Director / Director Biostatistics The Associate Director / Director, Biostatistics will lead the full scope of statistical strategy and execution for clinical development programs at Mineralys. This individual is accountable for the design, analysis, and interpretation of clinical trials, as well as statistical contributions to regulatory submissions, including NDA readiness. Operating in a fast-paced, pre-commercial biotech environment, this role requires a strong balance of strategic thinking and operational oversight, with high visibility across Clinical, Medical, and Regulatory teams. Key Responsibilities - Lead the full scope of Biostatistics activities for assigned clinical programs or indications - Define and execute statistical strategies for clinical trials and regulatory submissions - Design clinical studies, including endpoints, estimands, and sample size calculations - Serve as statistical lead on Study Executive Teams and Clinical Development Teams - Provide quantitative input into clinical development plans, including Go/No-Go criteria and probability of technical success - Ensure quality and timely delivery of statistical outputs, including interim, final, and integrated analyses - Contribute to regulatory submissions (e.g., NDA) and represent Biostatistics in interactions with FDA - Collaborate cross-functionally with Clinical, Medical, and Regulatory - Oversee CROs and/or internal teams; ensure quality, timeliness, and compliance of deliverables - Collaborate with internal leaders of Statistical Programming and Data Management - Supervise statistical programmers for QC and validation activities - Interpret analysis results and ensure accuracy in study reports, publications, and regulatory documents - Contribute to abstracts, posters, and presentations for internal and external stakeholders - Drive continuous improvement initiatives within Biostatistics and cross-functional processes Qualifications - PhD in Biostatistics, Statistics, or related field with ~8+ years of industry experience OR MS with ~11+ years of experience in drug development - Pharmaceutical/biotech industry experience required - Demonstrated experience providing statistical leadership at study or program level - Strong experience designing clinical trials and collaborating with cross-functional teams - Experience supporting regulatory submissions (NDA/BLA) - Experience interacting with regulatory authorities preferred - Experience overseeing CROs or external vendors - Experience supervising programming deliverables or QC activities - Strong knowledge of CDISC standards, data structures, and statistical methodologies - Working knowledge of SAS and/or R (oversight level, not heavy programming) - Experience with outcomes research preferred - Therapeutic area experience flexible; preference for chronic diseases or larger patient populations Core Competencies - Strong understanding of clinical development processes and regulatory expectations - Ability to lead and influence in a matrixed environment - Excellent communication skills; able to translate statistical concepts to non-statistical audiences - Demonstrated ability to balance urgency with quality - Analytical rigor with a pragmatic, execution-oriented mindset - Experience applying innovative statistical methodologies Travel - This position requires up to 10% travel. Frequently travel is outside the local area and overnight. This position is eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $200,000 - $230,000 #LI-Remote

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky” Mineralys is a fully remote company. Senior Director, Global Marketing Reporting to the CCO, the Senior Director, Global Marketing will lead the development and execution of the ex-U.S. commercial strategy. This individual will play a critical role in shaping global market strategy, ensuring alignment with U.S. commercial objectives, and optimizing long-term global revenue potential. This role requires a highly strategic and analytical leader who can operate cross-functionally across commercial, clinical, regulatory, and business development to define market entry strategies, influence development programs, and secure partnerships across key international markets. Key Responsibilities: Global Commercial Strategy (Ex-U.S.) - Lead global (ex-U.S.) market identification, prioritization, and segmentation across key geographies - Develop and execute go-to-market strategies tailored by geography and indication - Define optimal pathways to market entry, including indication prioritization Cross-Functional Leadership - Partner closely with Clinical and Regulatory teams to shape development programs that align with commercial objectives and regulatory requirements - Influence clinical study design and sequencing to maximize global commercial opportunity - Ensure alignment across stakeholders to maintain a unified strategy - Partner with Market Access to evaluate pricing and reimbursement dynamics across international markets, including health technology assessment (HTA) environments - Identify and mitigate risks related to international reference pricing and Most Favored Nation (MFN) implications Business Development & Partnerships - Lead business development efforts to identify, evaluate, and secure strategic partners for market entry - Structure and support partnership models (e.g., licensing, co-promotion, regional partnerships) - Manage partner strategy to ensure successful execution in priority markets Strategic Analytics & Decision-Making - Conduct rigorous market assessments, including epidemiology, competitive landscape, and access dynamics - Develop commercial forecasts and scenario analyses to inform prioritization and investment decisions - Provide strategic recommendations to senior leadership based on data-driven insights Required Experience: - 10+ years of biopharmaceutical commercial experience, including global or ex-U.S. marketing - Demonstrated success in multi-market strategy development and execution - Strong experience in chronic disease markets; cardiovascular experience preferred. - Proven ability to collaborate with clinical and regulatory teams to shape development programs - Experience in early-stage or pre-market environments (Phase II or earlier strongly preferred) - Track record of business development and partnership execution Capabilities & Skills - Exceptional analytical and strategic thinking skills, particularly in market access and pricing dynamics - Deep understanding of global reimbursement systems and HTA bodies (e.g., Europe, Japan) - Strong ability to navigate complex trade-offs between global and U.S. commercial strategies - Excellent cross-functional leadership and influence skills - Ability to operate effectively in a fast-paced, emerging biotech environment Travel - This position requires up to 20% travel. Frequently travel is outside the local area and overnight. These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $250,000 - $265,000 #LI-REMOTE

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky” Mineralys is a fully remote company. The Director / Sr Director, Human Resources – Commercial will serve as the primary HR Partner to Mineralys’ Commercial organization as the company prepares for its first commercial launch. This role will act as a trusted advisor to business leaders, aligning people strategies with commercial objectives while fostering a high-performance, compliant, and values-driven culture in a rapidly scaling, highly regulated environment. Key Responsibilities Strategic Business Partnership - Serve as a strategic HR partner to Commercial and Field leadership across Sales, Marketing, Market Access, Training and Commercial Operations - Translate commercial objectives into integrated people strategies that support rapid growth, capability building, and organizational effectiveness - Provide data-driven insights and recommendations on workforce planning, organizational design, job architecture, compensation planning and talent needs as the Commercial organization scales Talent Management & Development - Partner with leaders on talent assessment, succession planning, and leadership development initiatives - Supports annual objective setting and mid-year and year-end performance assessment processes - Participates in the design and execution of field incentive compensation programs - Supports all performance management processes, including coaching, feedback, and development planning - Identify capability gaps within the Commercial organization to deliver targeted development solutions Employee Relations & Engagement - Act as a first point of contact for employee relations matters, ensuring fair, consistent, and timely resolution in compliance with company policies and employment laws - Coach managers on effective people leadership, engagement, and change management during periods of growth and transformation - Support employee engagement initiatives that reinforce Mineralys’ values of Collaboration, Integrity, Quality, Trust, and Urgency Change Management & Organizational Effectiveness - Lead and support change management efforts related to commercial build-out, launch readiness, and evolving operating models - Support commercial teams to ensure alignment and consistency across a geographically dispersed workforce Compliance & Governance - Ensure adherence to all employment laws, regulatory requirements, and internal policies, particularly in a pharmaceutical commercial environment - Partner with Legal and Compliance to mitigate risk and support sound, compliant people decisions Qualifications Required - BS/BA degree in Human Resources, Business Administration, or a related field - 7+ years of progressive HR experience, with demonstrated success as an HR Business Partner - Experience supporting Commercial organizations, preferably within pharmaceutical, biotech, or life sciences companies - Strong knowledge of U.S. employment law and HR best practices - Proven ability to influence and partner effectively with senior leaders - Excellent communication, coaching, and problem-solving skills Preferred - Master’s degree or HR certification (e.g., SHRM-CP/-SCP, PHR/SPHR) - Experience supporting field-based sales organizations, including periods of rapid growth or launch - Familiarity with specialty pharma, rare disease, or launch-stage commercial models - Experience working in a matrixed, fast-paced, early-stage environment Travel - This position requires up to 10% travel. Frequently travel is outside the local area and overnight. US Salary Range: $200,000 - $250,000 #LI-Remote