
FirstPrinciples Holding Company
Remote Jobs
Venture Holding that starts and acquires B2B SaaS Companies and Agencies
5 Jobs
Member of Technical Staff, Engineering
FirstPrinciples Holding CompanyVenture Holding that starts and acquires B2B SaaS Companies and Agencies
• Contribute to the design and coding of the AI Physicist, a closed-loop research engine, including the development of tools to support hypotheses generation, peer review, physics based simulations, validation against experimental data and self-revision, among other things. • Write safe, testable code and set up automated unit tests to catch errors and apply lessons from recent research findings. • Explore and integrate SOTA tools into existing platforms to enhance model capabilities. These tools can provide advanced analysis and insights, furthering the understanding of theoretical physics. • Add self-improvement features that pass automated checks before deployment. • Track runtime metrics and suggest optimizations that keep the project efficient and sustainable. • Develop custom tech solutions tailored to the specific needs of researchers. This may include developing algorithms, data analysis tools, or other software to accelerate research in specific areas of theoretical physics. • Apply knowledge of product development principles and practices to ensure that the tools developed are useful and effective for theoretical physicists worldwide. • Collaborate with stakeholders to define requirements, prioritize features, and ensure successful delivery.
Director of Development
FirstPrinciples Holding CompanyVenture Holding that starts and acquires B2B SaaS Companies and Agencies
• Develop and execute a multi-year fundraising strategy targeting multi-million dollar commitments from diverse funding sources. • Build a portfolio approach balancing major gifts, foundation grants, government funding, and innovative financing mechanisms. • Create compelling narratives that position FirstPrinciples as the highest-impact funding recipient in the future of science. • Design metrics and accountability frameworks that demonstrate tangible progress toward scientific breakthroughs. • Identify, cultivate and build deep long-term relationships with high-net-worth individuals, science foundations, research institutions, philanthropists, government funding agencies and institutional donors. • Lead and organize exclusive donor engagement initiatives, exclusive funder events, and private donor roundtables. • Develop impact reports showing how donor contributions directly accelerate specific scientific discoveries. • Identify and secure large-scale, multi-year grants from major science foundations (e.g., Simons Foundation, Kavli Foundation, Wellcome Trust, Gates Foundation, etc.). • Navigate complex government funding mechanisms (NSF, DARPA, NSERC, ERC, Horizon Europe) to access research grants. • Structure and negotiate complex agreements that align donor incentives with FirstPrinciples’ mission to accelerate scientific discovery. • Expand FirstPrinciples' access to government research funding, impact-driven venture funding, and global science funding programs. • Structure and negotiate funding agreements and deal structures with sophisticated funders. • Manage due diligence processes with new funders and foundation partners. • Create funding syndicates that bring together multiple funders around shared scientific missions. • Over time, build and lead a world-class fundraising team, including grant writers, donor relations managers, and institutional fundraising specialists. • Work closely with FirstPrinciples’ leadership team to align funding strategies with overall growth objectives. • Design scalable fundraising processes, CRM systems, and funder engagement strategies. • Foster a culture of urgency, excellence, and scientific passion within the development team
Technical Partnerships Manager
FirstPrinciples Holding CompanyVenture Holding that starts and acquires B2B SaaS Companies and Agencies
• Identify and develop partnerships with cloud providers, compute platforms, AI research labs, and infrastructure companies across North America, Europe, and Asia, to work with and support FirstPrinciples in the form of compute credits, tooling, and technical collaboration. • Secure in-kind support such as GPU compute, cloud credits, data infrastructure, and engineering collaboration. • Build relationships with companies across the AI, cloud, developer tooling, and research infrastructure ecosystem. • Work closely with internal technical teams to understand infrastructure needs and translate them into partnership opportunities. • Ensure compliance with emerging AI and data regulations globally. • Structure win-win collaborations that provide value to partners while accelerating FirstPrinciples’ research and development projects. • Develop outreach strategies to identify and engage with high-impact technology partners. • Manage relationships with existing partners and ensure collaborations deliver meaningful outcomes. • Coordinate with internal teams to execute partnership initiatives effectively. • Track partnership outcomes and ensure they support FirstPrinciples’ research and development goals. • Help develop partnerships with universities, research institutes, and mission-aligned organizations. • Identify opportunities for joint initiatives, research collaborations, or events. • Help expand FirstPrinciples’ network across the scientific and technology ecosystem. • Represent FirstPrinciples in conversations with potential partners. • Prepare partnership proposals and collaboration frameworks. • Represent FirstPrinciples in international discussions around research infrastructure, AI collaboration, and open science initiatives. • Position FirstPrinciples as a trusted partner at the intersection of AI, physics, and advanced research infrastructure.
Research Fellow
FirstPrinciples Holding CompanyVenture Holding that starts and acquires B2B SaaS Companies and Agencies
• Improve Theo’s ability to produce scientifically sound, high-quality outputs in 2026; • Introduce new ideas, methods, and approaches that meaningfully shift system performance; • Bring deep domain expertise (PhD+ level) in one or more targeted research areas. • Research, design, and test novel model architectures that combine academic literature, NLP, symbolic reasoning, and structured scientific workflows. • Prototype and build embedding representations for physical concepts, mathematical objects, and logical structures, enabling models to reason over equations, abstractions, and scientific constraints rather than surface text alone. • Investigate alternatives to transformer-based architectures and deliver concrete recommendations. • Design and run targeted experiments to evaluate new architectural ideas, using empirical results to guide the development of next-generation model architectures. • Develop reinforcement learning loops that enable models to run internal and independent thought experiments. • Design and automate scalable data ingestion pipelines that aggregate scientific literature, metadata, equations, and experimental data. • Create custom benchmarks to measure physical understanding, mathematical reasoning, and failure modes in scientific reasoning and abstraction. • Refine and release curated datasets and baselines once internal validation is complete. • Run and track model training jobs while managing compute usage and budget constraints. • Design sandbox environments for controlled autonomous exploration. • Build evaluation frameworks using visual and statistical tools to identify strengths and blind spots. • Implement tests and guardrails that flag low-quality or unsafe outputs. • Maintain internal issue tracking with clear failure modes and fixes. • Work closely with engineers to ensure research is feasible and production-ready. • Communicate technical trade-offs clearly to non-technical stakeholders. • Present regular research updates tied to defined milestones.
Staff Physicist, Quantum Information and AI
FirstPrinciples Holding CompanyVenture Holding that starts and acquires B2B SaaS Companies and Agencies
• Help build an AI Physicist at the frontier of Quantum Information and AI • Review and critique model reasoning in quantum information and adjacent theory • Provide clear corrections, alternative derivations, and minimal counterexamples • Create gold-standard demonstrations and reference solutions suitable for training • Define metrics that capture proof validity, assumption tracking, and correct theorem usage • Design evaluation suites and rubrics that stress-test the model on hard Quantum Information tasks • Work and help build the Collaborators program