Entrada Therapeutics

The Organization What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1). 2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670). We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families. The Perfect Addition to Our Team You are passionate and dedicated to your work, with a commitment to overcome challenges and deliver on our potential to develop transformative therapies for patients and their caregivers. You bring energy and enthusiasm to your role, while recognizing that a steady and consistent effort is required to successfully develop novel medicines. The Opportunity The Regulatory Affairs team at Entrada is a dynamic, growing team. The Associate Director will support global regulatory activities for Entrada’s pipeline, with a focus on clinical-stage assets. Reporting to the Senior Vice President, Regulatory Affairs, the ideal candidate will collaborate with cross-functional teams to efficiently advance the global development of genetic medicines for rare and serious unmet medical needs. This high-impact role will be critical to the success of the Regulatory department and Entrada’s mission to discover, develop and commercialize life-changing medicines that are safe, effective and accessible to those who need them. Responsibilities - Support the global regulatory strategy for multiple clinical stage programs. - Partner on the development, preparation, and timely completion of health authority submissions, including the authoring, submission, and archiving for IND, CTA, and EU-CTR submissions. - Develop strong working relationships with Regulatory colleagues and cross-functional project teams to support achievement of timelines and portfolio deliverables. - Maintain strong relationships and communication with external stakeholders, including regulatory agencies, CROs, CDMOs, consulting groups, and other third parties. - Collaborate with various departments including Nonclinical, Quality, Manufacturing, and Clinical to maximize opportunities while ensuring alignment with regulatory requirements. - Lead or contribute to the development and review of procedures and work instructions aligned with GxPs, Guidance, industry standards, and corporate objectives. - Participate in study team meetings, providing updates and addressing questions. - Proactively identify opportunities and risks within our Regulatory department and the development programs, and support approaches to mitigate and resolve risks. The Necessities At Entrada, our passion for science, our devotion to patients and our values drives our behavior: - Humanity - We genuinely care about patients and about one another. - Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients. - Creativity - We are creative problem solvers. - Collaboration - We are more than the sum of our parts. - Curiosity - We have a growth mindset and push conventional thought and theory. To thrive on our team, you will need to come with: - BS or MS with at least 6+ years of increasing responsibility in Regulatory Affairs; an advanced degree, RAC, or education in a scientific field preferred. - A demonstrated record of accomplishment, including support and execution of both US and global regulatory strategies (ie, with IND, CTA, CTR, NDA, BLA, and/or MAA activities). - Knowledge of the drug development process, GxP regulations, ICH, and FDA Guidance. - Experience with rare diseases, pediatrics, genetic medicines, or leveraging expedited development pathways (eg, accelerated approval) is strongly preferred; experience with neuromuscular or ocular therapeutic areas is a plus. - A strong work ethic, excellent verbal and written communication skills, and a desire to work collaboratively with matrixed project teams. - Excellent organizational skills and the ability to work on multiple projects with tight timelines. - A motivated and driven attitude, with a proactive work style and a results-oriented mindset. - Integrity, a desire to learn and grow, and a commitment to excellence. - This is a US based remote position, with preference given to local New England based candidates. This role will require minimum quarterly travel to the Entrada Therapeutics Headquarters located in Boston, MA What We Offer: Meaningful Work, Fair Rewards, and Real Support At Entrada Therapeutics, we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position, along with insight into our compensation philosophy, in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset. But we also know it is more than just pay. When you join Entrada, you’ll be part of a mission-driven team with access to comprehensive health, dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions – offering paid, gender-inclusive parental leave, holistic support for your health and well-being, education reimbursement, discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Boston’s Seaport District, this puts you steps away from some of the best the city has to offer. “Our approach to compensation is grounded in transparency, equity and performance for the unique contributions each person brings. At Entrada, we know that meaningful work deserves meaningful reward — and we view compensation as one way we show appreciation for the collaboration, curiosity and commitment that drive our mission forward.” — Kerry Robert, SVP of People The salary for this opportunity ranges from $171,000-$205,000. The final base compensation offered will depend on several considerations which include but may not be limited to a candidate’s skills, competencies, experience and other job-related factors permitted by law. The final salary offered may fall outside of this range. #LI-GG1 #LI-Remote Equal Opportunity Employer Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. Third Party Staffing Agencies Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes. Privacy Statement Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.

The Organization What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1). 2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670). We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families. The Perfect Addition to Our Team You are passionate about clinical trial research and driven to advance drug development through rigorous analytics. With a strong foundation in statistics and clinical methodologies, you combine classical techniques with cutting-edge innovations. You thrive in fast-paced settings, handle competing priorities with ease, and eagerly step in where needed. You are results-oriented and collaborative, and you thrive when build strong relationships across teams to deliver impactful solutions. The Opportunity Reporting to the Senior Director, Biometrics, this individual will contribute to daily statistical activities and support the development of statistical approaches for clinical trials. Working closely with internal and external stakeholders, you will help manage a growing portfolio of trials. This role also offers the opportunity to support the continued growth of the biostatistics function at Entrada and gain valuable experience in a collaborative, fast-paced environment. Responsibilities - Support statistical strategy for assigned drug programs, including input to clinical development plans, clinical study concepts and protocols design, SAPs, clinical study reports, regulatory documentation and associated publications. - Accountable for oversight of the production of biostatistics deliverables (TFLs, including planned, post-hoc, and/or exploratory analyses) as performed by external resources. - Provide statistical strategy support and input in protocols, CSRs, and scientific presentations and manuscripts. - Review the randomization procedures and oversight of the production of randomization lists. - Review study Case Report Forms, data management plan and other data management related documentation to ensure that specific statistical requirements defined in the study protocol are met. - Oversee outsourced statistical CRO activities and deliverables, ensuring high quality and timely delivery. - Produce innovative tools and methodologies for statistical analysis through literature review. - Participate in the development of department strategies and cross functional initiatives on standards, infrastructure, and processes. The Necessities At Entrada, our passion for science, our devotion to patients and our values drives our behavior: - Humanity - We genuinely care about patients and about one another. - Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients. - Creativity - We are creative problem solvers. - Collaboration - We are more than the sum of our parts. - Curiosity - We have a growth mindset and push conventional thought and theory. To thrive on our team, you will need to come with: - Ph.D. in Statistics or a related field, with 6 + years of experience in statistical analysis within the biotech/pharmaceutical industry. - Experience with a broad array of statistical approaches and experience in proposing novel approaches to support acceleration of clinical programs. Knowledge in the latest developments in the analytical world including machine learning and artificial intelligence is a plus. - Solid understanding of regulatory guidelines on drug development, regulatory submissions, and statistical practice. - Strong statistical programming skills (R, SAS, Python). - Understanding of regulatory guidelines related to submission of datasets using CDISC, development of SDTM and ADaM specifications. - Previous vendor management experience is preferred. - Previous experience in Neuromuscular, Ophthalmology or related TA is preferred. - Excellent verbal and written communication skills with a strong attention for detail. - This is a US based remote position, with preference given to local New England based candidates. This role will require a minimum quarterly travel to the Entrada Therapeutics Headquarters located in Boston, MA.LI-JF1 #LI-Remote What We Offer: Meaningful Work, Fair Rewards, and Real Support At Entrada Therapeutics, we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position, along with insight into our compensation philosophy, in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset. But we also know it is more than just pay. When you join Entrada, you’ll be part of a mission-driven team with access to comprehensive health, dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions – offering paid, gender-inclusive parental leave, holistic support for your health and well-being, education reimbursement, discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Boston’s Seaport District, this puts you steps away from some of the best the city has to offer. “Our approach to compensation is grounded in transparency, equity and performance for the unique contributions each person brings. At Entrada, we know that meaningful work deserves meaningful reward — and we view compensation as one way we show appreciation for the collaboration, curiosity and commitment that drive our mission forward.” — Kerry Robert, SVP of People The salary for this opportunity ranges from $190,000-$231,000. The final base compensation offered will depend on several considerations which include but may not be limited to a candidate’s skills, competencies, experience and other job-related factors permitted by law. The final salary offered may fall outside of this range.#LI-JF1 #LI-Remote Equal Opportunity Employer Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. Third Party Staffing Agencies Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes. Privacy Statement Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description The Executive Director, Investor Relations will be responsible for developing and executing a comprehensive investor relations strategy that enhances Entrada’s visibility, credibility, and positioning within the financial community and broader stakeholder landscape. Reporting to the Chief Financial Officer, the ideal candidate will combine deep investor relations and financial expertise with strong scientific and clinical fluency to build investor confidence, drive awareness, and support long-term shareholder value creation for a NASDAQ-listed biotechnology company with an expanding portfolio of clinical-stage programs. Responsibilities - Drive the strategic direction, planning, and execution of the investor relations function, including financial communications. - Serve as a trusted advisor to senior leadership by providing insight and guidance on investor messaging, communications effectiveness, market dynamics, and investor sentiment. - Act as the primary point of contact to the investment community, responding to external inquiries in an accurate, appropriate, and timely manner. - Establish and maintain strong relationships with biotechnology-focused buy-side and sell-side analysts and institutional investors. - Develop and maintain proactive engagement with investors and analysts to clearly communicate the Company’s long-term vision, clinical and platform strategy, differentiation, opportunity, risk factors, and key milestones. - Lead the development and coordination of financial and investor communications, including earnings releases, investor webcasts, investor presentations, and the investor relations section of the Company website. - Coordinate cross-functionally with Finance and Legal to support the timely and compliant execution of external financial disclosures and investor communications. - Lead the Company’s participation in investment community events, including investor conferences, non-deal roadshows, analyst days, and targeted investor meetings. - Develop, track, and report key investor relations metrics in our Irwin investor relations system to assess program effectiveness and inform continuous improvement. - Monitor published research analyst reports covering the Company and analyze biopharmaceutical industry trends, investor perceptions, and competitor communications to inform strategic positioning and messaging. - Support capital markets activities, including potential financings and strategic transactions, in close partnership with the CFO and senior leadership. - Partner closely with the Chief Corporate Affairs Officer to ensure alignment with the broader corporate communications strategy and Entrada brand. - Manage external agencies and vendors, as needed, ensuring high-quality deliverables and disciplined management of external spend. - Ensure all investor communications and activities fully comply with SEC regulations and disclosure requirements, including Regulation FD and NASDAQ listing standards. Qualifications - Bachelor’s degree required; advanced degree (PhD, MD, MBA, or MS in life sciences, biotechnology, or finance-related discipline) preferred. - 10+ years of progressive experience in investor relations within the biotechnology or pharmaceutical industry. - Experience supporting investor relations for a publicly traded biotechnology or pharmaceutical company, preferably NASDAQ-listed. - Experience in a clinical-stage or pre-commercial biotechnology environment strongly preferred. - Established relationships within the biotechnology buy-side and sell-side community strongly preferred. - Proven ability to develop and execute investor relations strategies that effectively reach and influence target audiences. - Strong financial acumen and financial modeling familiarity, with the ability to clearly communicate complex financial and clinical information to diverse external stakeholders. - Develop clear and compelling PowerPoint presentations for earnings calls, investor meetings, and board discussions. - Demonstrated experience supporting equity offerings, capital markets transactions, or other strategic financings preferred. - Demonstrated ability to lead the use of investor relations software solutions to support investor engagement, shareholder monitoring, and analytics. - Excellent written and verbal communication skills, with exceptional attention to detail. - Highly self-directed with exceptional project management and organizational skills. - Experience building, managing, and scaling investor relations capabilities across internal teams and external partners. - Demonstrated ability to work collaboratively and influence across functions and with senior executives. - Deep understanding of the drug development lifecycle and the regulatory and disclosure environment for biopharmaceutical companies. - Experience preparing senior executives and Board members for investor engagement and earnings communications preferred. - Ability to travel approximately 25% as required to support investor engagement and key industry events. Benefits - Comprehensive health, dental, and vision coverage. - Life and disability insurance. - 401(k) match. - Paid, gender-inclusive parental leave. - Holistic support for health and well-being. - Education reimbursement. - Discretionary time off. - Commuting benefits aligned to your working model.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description We are seeking a dynamic Pharmacometrics Consultant who will bring extensive expertise in quantitative pharmacology to our clinical stage programs. The ideal candidate will have a strong background in the applications of model-based drug development within the biotechnology or pharmaceutical industry and be passionate about translating science into approved and accessible medicines. You will report directly to the Head of Clinical Pharmacology and partner closely with various functions of our growing organization. - Use modeling approaches to advance clinical and translational research at Entrada Therapeutics. - Support the development of diverse modeling strategies and execution, in collaboration with the Head of Clinical Pharmacology, to bring value to the Entrada portfolio. - Work collaboratively with functional partners, including Clinical Development, Biostatistics, Non-Clinical Product Development, Clinical Operations, and Regulatory to deliver on both project team and corporate objectives. - Author regulatory documents including analysis plans, study reports, population PK reports, exposure-response analyses reports and other similar documents. - Monitor work with CROs and other external vendors to ensure compliance with agreed protocols, quality standards, and timelines. Qualifications - Ph.D. in pharmaceutical sciences, pharmacology, pharmacometrics, pharmacokinetics, or related discipline or Pharm.D. or M.D. with relevant experience. - 7+ years’ experience with background in the application of mathematical, pharmacokinetics, and statistical methods within pharma/biotech industries or drug development. - Experience using Phoenix WinNonlin, R, NONMEM, MATLAB, or other pharmacokinetic and modeling software. - Strong mathematical model development and analytical skills. Requirements - This is a US based contract position, looking for support from 20 – 35 hours per week. The Necessities - Humanity - We genuinely care about patients and about one another. - Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients. - Creativity - We are creative problem solvers. - Collaboration - We are more than the sum of our parts. - Curiosity - We have a growth mindset and push conventional thought and theory. Equal Opportunity Employer Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. Third Party Staffing Agencies Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes. Privacy Statement Entrada Therapeutics, Inc. respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process your Personal Information. Please reference our privacy statement to understand how and when your data is being used.