Dianthus Therapeutics

About Us We are developing potentially best in class therapies for patients living with severe autoimmune diseases. Our lead antibody, claseprubart (DNTH103), is purposefully engineered with extended half-life, improved potency, and high selectivity for only the active C1s complement protein that drives disease pathology – enabling less frequent and more convenient self-administered subcutaneous injections. Our second clinical candidate, DNTH212 is a first and potentially best in class, bifunctional inhibitor that targets clinically validated and complementary disease modifying mechanisms, Type 1 IFN suppression and B cell modulation – enabling potential for improved clinical outcomes and patient friendly convenient, self-administered subcutaneous injections. To learn more, please visit www.dianthustx.com and follow us on LinkedIn. About the Role We are building our Clinical team and need two Senior Clinical Trail Associates who are open to owning end-to-end processes. You will report directly to the respective Senior Director, Clinical Development Operations global leads. As the Senior Clinical Trial Associate (Sr. CTA)/ Sr. Associate, you will play a crucial role in the Clinical Development Operations (CDO) department to support the planning, execution, and management of clinical trials in accordance with regulatory requirements and industry best practices. In this role, you will collaborate with cross functional study teams, clinical Research Organizations (CROs), and other external vendors to ensure the successful delivery of clinical study activities. You must have experience supporting global clinical study teams in order to be successful. Experience in rare diseases is ideal, however not required. We are looking for someone who can grow with our organization and will continue to support your ongoing development. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. We are open to you working remotely. Key Responsibilities - Provides support to assigned clinical studies, taking on various responsibilities to support project and study deliverables. - Coordinates, attends and may lead study team meetings; ensures appropriate meeting scheduling and documentation, including creation, distribution and filing of meeting agendas and minutes. - Maintains and generates applicable study trackers and documents (for example: action-decision log, storyboard, patient enrollment and IRB approvals). - Monitors clinical trial insurance and license agreements across studies and work with vendors to ensure current agreements. - Supports the development and review of study documents, including study manuals. - Maintains knowledge and acts as team super-user or subject matter expert for study-related systems and processes. - Manages deliverables and navigates changing priorities. - Supports the clinical team with coordination and preparation for investigator meetings, PI calls, conferences as well as internal clinical meetings. - Supports management of the Trial Master File according to Sponsor Oversight plan to ensure accuracy and completeness. - Assists with study budget oversight, including invoice tracking, reconciliation and collaboration with cross-functional teams and vendors. - Participates in vendor selection and management meetings (e.g., CROs, IVRS, Central Labs, etc). Experience - BA/BS degree or equivalent, relevant work experience. - Minimum of 5 years’ experience working on clinical studies in pharmaceutical, biotech, or CRO setting preferred. Prior CTA experience required. - Excellent interpersonal and communication skills with ability to work collaboratively across functional teams. - Strong organizational and time management skills, and strong attention to detail. - Knowledge of global regulatory and compliance requirements for clinical research. - Experience with essential documentation for Trial Master Files required. - Knowledge of drug development, clinical operation processes, medical terminology, and procedures according to FDA GCP/ICH regulatory guidelines. - Excellence with MS Office products Word, Excel, SharePoint, PowerPoint. - Experience working with clinical trial systems (CTMS, IRT, EDC) preferred.

About Us We are developing potentially best in class therapies for patients living with severe autoimmune diseases. Our lead antibody, claseprubart (DNTH103), is purposefully engineered with extended half-life, improved potency, and high selectivity for only the active C1s complement protein that drives disease pathology – enabling less frequent and more convenient self-administered subcutaneous injections. Our second clinical candidate, DNTH212 is a first and potentially best in class, bifunctional inhibitor that targets clinically validated and complementary disease modifying mechanisms, Type 1 IFN suppression and B cell modulation – enabling potential for improved clinical outcomes and patient friendly convenient, self-administered subcutaneous injections. To learn more, please visit www.dianthustx.com and follow us on LinkedIn. About the Role We are seeking a strategic, creative, and execution-oriented VP, Corporate & Internal Communications to build and lead a modern, high-impact communications function in a fast-growing biotech company. This role sits at the intersection of people, corporate brand, and business strategy—responsible for shaping how we communicate internally and externally, strengthening employee engagement, elevating our corporate brand, and ensuring a consistent and compelling company narrative across all audiences, while operating as predominantly a remote company. You will serve as a trusted advisor to senior leadership and partner closely with the VP of Marketing and VP of Investor Relations to ensure alignment across corporate and internal communications. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. We are open to you working remotely - within the contiguous United States. Key Responsibilities Corporate Communications - Lead the redesign and ongoing evolution of the company’s external website to reflect brand, strategy, and scientific innovation. - Ensure the website serves as a best-in-class platform for storytelling, recruiting, investor visibility, and patient education and engagement. Internal Communications & Employee Experience - Develop and implement a forward-thinking internal communications strategy aligned with the company’s mission, vision, and values. - Design and execute a comprehensive internal communications approach for a fully remote workforce that drives engagement, clarity, and connection. - Create and manage a dynamic, year-round internal communications and employer brand calendar that proactively aligns messaging with business priorities, milestones, and organizational needs. - Oversee all internal communication channels to ensure employees are informed, engaged, and connected. - Direct the production, content strategy, and ongoing evolution of the company’s employee intranet as a central hub for culture, information, and collaboration. Executive & Leadership Communications - Craft and deliver executive communications that reflect leadership voice, company values, and business priorities. - Ensure consistency of tone and messaging across all employee-facing forums, including town halls, company updates, and enterprise-wide communications. - Anticipate communication needs throughout the year and proactively prepare executive messaging aligned with key business moments. - Partner with Finance, Investor Relations, and Business Development to support executive communications and to ensure consistent messaging aligned with company news releases Corporate Brand Elevation - Enhance and update our corporate brand image via refresh of look and feel, taglines, and corporate narrative to reflect position as an innovative, late-stage biotech company - Build and elevate the company’s employer brand through innovative, authentic, and data-driven social media campaigns. - Partner with Talent and Marketing to position the company as a destination for top biotech talent. - Oversee content strategy and storytelling across external platforms, including LinkedIn, careers pages, and employee-generated content. - Plan and execute social media content with a focus on LinkedIn to raise Dianthus’ visibility, highlight our commitment to patients, spotlight employees and our science, recognize corporate achievements, and support recruiting initiatives. All-Company Meetings & Events - Own the agenda development, narrative, and content management for biannual all-company meetings and regular virtual town hall meetings. - Partner with senior leadership to craft compelling presentations and storytelling. - Ensure meetings are engaging, informative, and reinforce company strategy, culture, and priorities. Experience - 10+ years of progressive experience in communications, including leadership roles in biotech and/or pharma - Proven experience leading major communications initiatives, including: - Website redesign and digital content strategy - Internal communications in remote or distributed organizations - Corporate brand development and social media campaigns - Executive and leadership communications - Strong executive presence with experience advising senior leaders and influencing at the highest levels of the organization. - Exceptional writing, storytelling, and content strategy skills, with the ability to translate complex scientific information into clear, compelling narratives. - Demonstrated ability to balance strategic thinking with hands-on execution. - Experience working cross-functionally with Marketing, HR/People, Investor Relations, Finance, and Clinical/Medical Affairs teams. - Strong project management and organizational skills with the ability to manage multiple priorities in a fast-paced environment. - Data-driven mindset with experience establishing and tracking communication effectiveness metrics. What Success Looks Like - A cohesive, compelling company narrative consistently reflected across internal and external channels. - A modern, high-performing website that supports brand, recruiting, investor engagement, and patient connection. - An engaged, informed, connected, and aligned remote workforce. - Strong, authentic leadership communication that builds trust and clarity. - A differentiated employer brand that attracts top-tier talent. - High-impact all-company meetings and town halls that energize and align employees.

Role Description We are seeking a motivated physician to join the Clinical Development team for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). This position is designed for individuals looking to build a strong foundation in clinical development within a collaborative environment. The Medical Director MD, Clinical Development will report to the VP, Clinical Development, and will work in conjunction with the VP, Senior Medical Director and Clinical Scientist(s) to prepare, review and execute clinical study protocols, data interpretation, and clinical study reports. You will act as the lead medical monitor with oversight of the CRO medical monitors and execution of the medical monitoring plan. In addition, you will collaborate with cross-functional teams to develop and review statistical analysis plans, informed consent forms, data listings, regulatory filings and responses to health authorities and ethics committees. You will also work with the medical safety colleagues to ensure the safety of trial participants including interacting with the trial DSMB, reviewing ongoing data for potential safety trends, and evaluating cases of interest as they occur. This is an opportunity to join a growing organization with an expanding pipeline and drive clinical strategy for auto-immune neurology indications. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. We are open to you working remotely. Key Responsibilities - Medical monitoring of the assigned clinical trial/s, data and safety review and working closely with the clinical operations, safety physicians, CRO medical monitors, and other external partners to oversee conduct of the assigned clinical trial/s. - Review safety data, adverse events, and protocol deviations in collaborations with cross-functional teams. - Provide medical input to study teams, investigators and CRO partners. - Supporting the design and execution of clinical trials, including protocol development and study oversight. - Literature review, attending scientific meetings, advisory boards, and investigator meetings, and presenting the protocol to relevant internal and external stakeholders. - Contribute to regulatory documents and ethics committees, as appropriate. Qualifications - MD with board certification in the US, with clinical experience in Neurology or executing neurology clinical trials preferred. - Previous experience in industry-supported clinical research in the pharma/biotech/CRO setting with familiarity with clinical study documentation, processes, and execution preferred. - Medical monitoring or pharmacovigilance experience. - Strong ability to work collaboratively with cross-functional study teams, study vendors and clinical trial sites. - Strong analytical and communication skills. - Thorough understanding of GCP/regulatory requirements. - Proactive – the ability to identify challenges and risks and implement appropriate actions with some supervision. - Motivated – highly motivated and self-starter; able to organize and perform complex tasks with minimal supervision. - Collaborative – to coordinate activities of internal cross-functional study team as well as external vendors as applicable. - Open-minded – listen to ideas from others and seek guidance when applicable; inform manager as situations arise to brainstorm and seek best solutions.

About Us We are developing potentially best in class therapies for patients living with severe autoimmune diseases. Our lead antibody, claseprubart (DNTH103), is purposefully engineered with extended half-life, improved potency, and high selectivity for only the active C1s complement protein that drives disease pathology – enabling less frequent and more convenient self-administered subcutaneous injections. Our second clinical candidate, DNTH212 is a first and potentially best in class, bifunctional inhibitor that targets clinically validated and complementary disease modifying mechanisms, Type 1 IFN suppression and B cell modulation – enabling potential for improved clinical outcomes and patient friendly convenient, self-administered subcutaneous injections. To learn more, please visit www.dianthustx.com and follow us on LinkedIn. About the Role The Senior Director/Executive Director of Regulatory Affairs will develop and execute global regulatory strategies in collaboration with key stakeholders. You will serve as the global regulatory lead for our new asset (DNTH212) in multiple programs, providing expert guidance to cross-functional teams, driving global regulatory submissions, acting as primary liaison with Health Authorities, and interpreting applicable Health Authority regulations and guidance documents to ensure compliance. This is a unique opportunity to join a growing organization with an expanding pipeline, and to play an integral role in the in the global development of assigned programs from early phase through marketing approval. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. We are open to you working remotely within the contiguous United States or Canada. Key Responsibilities - Represent regulatory on cross-functional teams; provide leadership and strategic direction for regulatory deliverables. - Lead planning and provide hands-on support for development and on-time delivery of clear and persuasive global regulatory submission documents, including INDs/CTAs, DSURs, pediatric investigation plans (PIPs), responses to Health Authority (HA) queries, and briefing documents. - Identify, communicate, and propose resolutions to routine and complex strategic issues - Serve as primary contact and build trusted relationships with Health Authorities for assigned program(s). - Maintain expert knowledge in US and international regulations and provide proactive regulatory intelligence. - Assess opportunities and oversee applications for expedited pathways (eg, fast track or breakthrough designation or PRIME) and/or orphan drug designations. - Lead preparation for and conduct of Health Authority meetings. - Evaluate competitive landscape, regulatory approval pathway(s), and labeling precedent(s). - Identify, engage and collaborate with external regulatory experts and consultants. - Perform regulatory strategic assessments for new product candidates and new indications. - Support departmental initiatives, including process and infrastructure development, regulatory intelligence, budgeting, and authoring of departmental documents (eg, SOPs and Regulatory Development Plans). Experience - Bachelor's degree and a minimum of 12 years of direct experience in Regulatory Affairs; rare disease, neurology, CMC, advanced degree (MS, PharmD, PhD), and/or combination product experience a plus. - Demonstrated track record of successful interactions with FDA and other Health Authorities. - Expert understanding of scientific principles and regulatory requirements relevant to global drug development. - Preparation of nonclinical and clinical sections of regulatory filings, including IND/CTAs, PIPs, briefing documents, and BLA/MAAs. - Preparation for and conduct of Regulatory meetings with global Health Authorities for complex issues. - Strong interpersonal skills and the ability to collaborate effectively with subject matter experts. - Demonstrated leadership, problem-solving ability, flexibility, and teamwork. - Excellent communication, writing, and presentation skills, with the ability to effectively convey critical information to project teams, senior management, and external stakeholders. - Strong project management skills. - Ability to work effectively in a fast-paced, collaborative, and dynamic environment.

About Us We are developing potentially best in class therapies for patients living with severe autoimmune diseases. Our lead antibody, claseprubart (DNTH103), is purposefully engineered with extended half-life, improved potency, and high selectivity for only the active C1s complement protein that drives disease pathology – enabling less frequent and more convenient self-administered subcutaneous injections. Our second clinical candidate, DNTH212 is a first and potentially best in class, bifunctional inhibitor that targets clinically validated and complementary disease modifying mechanisms, Type 1 IFN suppression and B cell modulation – enabling potential for improved clinical outcomes and patient friendly convenient, self-administered subcutaneous injections. To learn more, please visit www.dianthustx.com and follow us on LinkedIn. About the Role As the Director, Talent Acquisition, you will lead and scale full-cycle recruiting during a pivotal growth phase as we advance a Phase 3 clinical program. Reporting to the CPO, you will drive talent acquisition across all functions while building scalable recruiting practices, managing external search partners, and delivering an exceptional candidate experience. Success in this role requires prior experience independently leading the talent acquisition function, making hiring strategy and process decisions. This is a hands-on role for someone who thrives in a fast-moving biotech environment and is comfortable flexing beyond recruiting to support broader HR initiatives such as onboarding and employer branding. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. We are open to you working remotely. Key Responsibilities Manage full-cycle recruiting for roles in the US, UK, and Canada, across all functional areas, including Clinical Development, Quality, Technical Operations, Commercial, and Corporate functions. Drive the interview and offer process, including scheduling, crafting job descriptions, conducting interviews, sharing feedback, and negotiating compensation packages. Manage and optimize the use of external recruiters and search firms, ensuring quality, cost-effectiveness, and alignment with company standards. Scale and evolve recruiting practices as the company approaches commercialization. Own the end-to-end candidate experience, ensuring a high-touch, professional, and engaging process that reflects the company’s values. Partner with HR and leadership to help build and articulate the employer brand, including messaging, recruiting materials, and presence on relevant platforms. Support onboarding processes to ensure a seamless transition from offer acceptance to employee integration. Develop and track recruiting metrics (time to fill, quality of hire, candidate experience, etc.) and use data to drive improvements. Ensure compliance with applicable employment laws and internal policies throughout the recruiting process. Experience Bachelor’s degree or equivalent. 8+ years of progressive talent acquisition experience within biotech, pharma, or life sciences. Experience leading the Talent Acquisition function and decision-making processes. Proven experience recruiting across technical, scientific, and commercial roles. Demonstrated success scaling recruiting practices in a growing organization (late-stage or pre-commercial preferred). Experience managing external recruiters and search firms. Strong stakeholder management skills with the ability to influence senior leaders. Highly organized, adaptable, and comfortable operating in ambiguity. High attention to detail, strong sense of urgency, and stellar time management / organizational skills. Collaborative mindset with a willingness to roll up sleeves and support broader HR needs.