Ambros Therapeutics, Inc.

ROLE: Director/Associate Director Program Management DEPARTMENT: Program Management REPORTING TO: Vice President Program Management LOCATION: A corporate office or remote from the Employee’s home office SALARY BAND: $180,000 to $214,000 with an annual bonus target of 20%. Final compensation will be commensurate with the candidate’s experience, education, skills, and overall alignment with the role’s requirements. EQUITY GRANT ELIGIBLE: Yes POSITION SUMMARY: Reporting to the Vice President Program Management, the Director/AD Program Management will play a critical role in driving Ambros Therapeutics, Inc.’s Core Purpose lead, integrate, and drive cross-functional execution of research and development (“R&D”) and general and administrative (“G&A”) programs and projects. This individual will be responsible for ensuring programs/projects run seamlessly and in alignment with company strategy, execution, and delivery of key milestones. The role requires end-to-end program strategy, leading through influence cross-functionally, development of detailed timelines, budgets and resource forecasts, ensuring regulatory and development alignment, translating complex operational information into clear executive insights, coordination with internal stakeholders, working teams, executive leadership, and strategic partners. ESSENTIAL DUTIES AND RESPONSIBILITIES - Lead the cross-functional planning, execution, and tracking of various programs/projects from creation through final delivery. - Partner with functional leaders to align strategy, priorities, timelines, and resource needs. - Drive integrated project plans, governance, risk management, and decision-making processes to ensure achievement of corporate and program/project objectives. - Contributes to strategic planning, portfolio prioritization, and scenario modeling to support executive decision-making. - Ensure clear program goals, defined deliverables, accountability structures, and transparent communication across teams and leadership. - Provide proactive identification, assessment, and mitigation of program/project risks, dependencies, and operational challenges. - Collaborate with internal and external stakeholders, including partners and vendors, to ensure alignment and effective execution. - Serve as the central point of integration across functional areas, facilitating effective governance meetings, program/project reviews, and executive reporting. - Review and contribute to key program/project documentation, including development plans, clinical timelines, regulatory strategies, budget forecasts, and governance materials. MINIMUM EXPERIENCE, EDUCATION, CERTIFICATIONS, & LICENSES: - Bachelor’s degree in project management, health sciences, or a related field strongly preferred; associate’s degree or equivalent work experience in relevant project management and pharmaceutical industry experience will be considered. - Minimum of 8 years of experience in program management or cross-functional project leadership within the biotechnology or pharmaceutical industry, including a strong understanding of the drug development process through commercialization. - Project Management certifications (e.g., PMP) and/or life‑sciences–specific training (e.g., biotechnology or clinical research project management certificates) strongly preferred. - Experience in clinical development or commercial program/project management preferred. - Demonstrated integrity, accountability, and commitment to operational excellence and strategic program execution. SKILLS & QUALIFICATIONS: - Problem solver with an entrepreneurial spirit, curious and innovative mindset, and ability to thrive in an agile environment. - Superior verbal, written, and presentation communication skills in English, with the ability to engage effectively across all levels of the Company and with external stakeholders. - Proven ability to develop and sustain relationships with internal and external stakeholders. - Excellent leadership skills and demonstrated ability to manage cross functionals project teams of highly performing and motivated individuals. - Skilled in program and project management methodologies and an understanding of the drug development process (including clinical operations, regulatory, CMC), business development, corporate administration, and commercialization planning. - Demonstrated ability to organize, prioritize, and work effectively with minimal supervision in a constantly changing environment. - High degree of professionalism, empathy, and discretion. - Detail-oriented with strong organizational, prioritization, and time management skills. - Collaborative and supportive mindset, able to engage in team and individual performance objectives. - Must have knowledge of and be willing to comply with all regulatory/compliance policies and best practices consistent with the role and Company’s policies. - Ability to assess the inherent risks of a situation, their potential impact on a project and, based on this information, involve the appropriate team members to make timely decisions. - Ability to read and comprehend complex materials, including medical and scientific literature, policies, procedures, and instructions in English; write reports and memos; use logic and data to solve problems; assess needs and take appropriate actions; all with reasonable independence, business judgment, and professional discretion. - Upholds high ethical standards and maintains integrity in all activities. - Proficient with Microsoft Office Suite, Microsoft Project, Microsoft Planner, Zoom, Teams, and related software. WORK LOCATION AND TRAVEL REQUIREMENTS: This position is based from an Ambros corporate office or remote from the Employee’s home office, subject to Company policy and business needs. If remote, a dedicated home office space that is professional in appearance, quiet, and secure where confidential conversations can occur and a high-quality high-speed internet connection are required. Regardless of primary work location, the role requires in-person presence approximately once per month for multi-day meetings at the corporate headquarters or other designated locations, as determined by business or department priorities. Occasional domestic travel is required, including overnight stays. Travel expectations may reach up to 10%, depending on operational priorities and company needs. PHYSICAL REQUIREMENTS & ENVIRONMENTAL CONDITIONS: This position is primarily performed in a professional office or home-office setting. With or without reasonable accommodation, the employee must be able to: - Operate a computer and standard office equipment; - Communicate effectively in person, via telephone, and through video conferencing platforms; - Travel independently, including overnight and international trips, and travel by personal vehicle and transit systems; and - Navigate office environments and other professional settings. Additional requirements include: - Prolonged periods of sitting, standing, and walking; - Occasional lifting or carrying of items up to 20 pounds; - Ability to read, comprehend, and apply policies, procedures, and regulations written in English; - Ability to write clear, factual, and grammatically correct communications and reports in English; and - Ability to use logic and data for problem-solving and to exercise sound judgment.

ROLE: Senior Director, Technical Accounting DEPARTMENT: Finance & Accounting REPORTING TO: Senior Vice President Finance and Administration LOCATION: A corporate office or remote from the Employee’s home office SALARY BAND: Senior Director, Technical Accounting $225,000 to $260,000 with an annual bonus target of 25%. Final compensation will be commensurate with the candidate’s experience, education, skills, and overall alignment with the role’s requirements. EQUITY GRANT ELIGIBLE: Yes POSITION SUMMARY: Reporting to the Senior Vice President Finance and Administration, the Senior Director, Technical Accounting will play a critical role in driving Ambros Therapeutics, Inc.’s financial reporting excellence, accounting integrity, and operational scalability as the Company advances its clinical pipeline and corporate growth initiatives. This individual will be responsible for leading the Company’s technical accounting strategy, including complex accounting transactions, financial reporting policies, and audit readiness. The role requires strong technical expertise in U.S. GAAP, exceptional communication and organizational skills, professionalism, sound judgment, and adherence to regulatory and ethical standards governing financial reporting and internal controls. ESSENTIAL DUTIES AND RESPONSIBILITIES - Lead and prepare all technical accounting matters, including interpretation and implementation of U.S. GAAP and emerging accounting standards. - Serve as a subject matter expert for accounting implications of financing transactions, valuation matters, and potential capital markets activities - Drive accounting assessments and documentation for complex arrangements, including clinical and contract manufacturing contracts, licensing and collaboration agreements, equity transactions, leases and business combinations. - Build and operationalize the Finance department's public-company reporting infrastructure to ensure the organization is fully prepared to meet SEC filing obligations as a public company - Responsible for SEC reporting to ensure the timely and accurate preparation of external financial reporting, including the drafting and finalization of Forms 10‐Q, 10‐K, S-1 and other SEC filings as required in compliance with SEC regulations and US GAAP disclosure requirements - Coordinate drafting and reviewing of SEC documents with internal and external parties (Executive Leadership Team, IR, auditors and outside legal counsel) - Work with Accounting department to ensure the timely and accurate preparation of monthly, quarterly, and annual financial statements (and related footnote disclosures) in accordance with US GAAP - Provide leadership in audit readiness, including coordination with external auditors and preparation of supporting documentation. - Assist with the administration of the equity compensation plan, including the accounting for RSUs/RSAs, Options and employee stock purchase plan under ASC 718. - Work closely with business leaders to prepare to scale end-to-end business processes, systems, and financial controls to support of the future growth of the Company into a commercial entity. This includes developing and executing Gross to Net (GTN) Revenue accounting process, systems and assumptions for GTN forecasts and budgets. - Oversee the design of internal control program and leads team to implement and perform the appropriate control functions to allow for a strong control environment. This also includes execution and testing of controls to ensure overall compliance with SOX 404 requirements and management certifications - Collaborate with cross-functional teams to establish and maintain scalable accounting policies, procedures, and internal controls appropriate for a growing biotechnology company. - Assist with Finance board meeting and audit committee materials MINIMUM EXPERIENCE, EDUCATION, CERTIFICATIONS, & LICENSES: - Bachelor’s degree in Accounting, Finance, or related field required; Master’s degree preferred. - Active CPA license required. - Minimum of 8+ years of progressive accounting experience, including significant technical accounting responsibilities within publicly traded biotechnology, pharmaceutical, or life science companies. - Advanced understanding of GAAP, SEC Reporting, and financial analysis - Experience with disclosure management platform, Merrill Bridge, Workiva or RR Donnelley - Strong experience with complex accounting topics, including revenue recognition for collaboration arrangements, stock-based compensation, lease accounting, fair value measurements, and business combinations. - Proven track record of supporting external audits and building accounting infrastructure in high-growth environments. - Demonstrated integrity, accountability, and commitment to financial accuracy and compliance. SKILLS & QUALIFICATIONS: - Problem solver with an entrepreneurial spirit, curious and innovative mindset, and ability to thrive in an agile environment. - Superior verbal, written, and presentation communication skills in English, with the ability to engage effectively across all levels of the Company and with external stakeholders. - Proven ability to develop and sustain relationships with auditors, advisors, consultants, and cross-functional business leaders. - Excellent leadership skills and demonstrated ability to manage cross-functional project teams of highly performing and motivated individuals. - Skilled in technical accounting research, financial reporting, policy development, and implementation of accounting standards. - Demonstrated ability to organize, prioritize and work effectively with minimal supervision in a constantly changing environment. - Must have knowledge of and be willing to comply with all regulatory/compliance policies and best practices consistent with the role and Company’s policies. - Ability to assess the inherent risks of a situation, their potential impact on a project and, based on this information, involve the appropriate team members to make timely decisions. - Ability to read and comprehend complex materials, including medical and scientific literature, policies, procedures, and instructions in English; write reports and memos; use logic and data to solve problems; assess needs and take appropriate actions; all with reasonable independence, business judgment, and professional discretion. - Upholds high ethical standards and maintains integrity in all activities. - Proficient with Microsoft Office Suite and related software. WORK LOCATION AND TRAVEL REQUIREMENTS: This position is based from an Ambros corporate office or remote from the Employee’s home office, subject to Company policy and business needs. If remote, a dedicated home office space that is professional in appearance, quiet, and secure where confidential conversations can occur and a high-quality high-speed internet connection are required. Regardless of primary work location, the role requires in-person presence approximately once per month for multi-day meetings at the corporate headquarters or other designated locations, as determined by business or department priorities. Occasional domestic travel is required, including overnight stays. Travel expectations may reach up to 10%, depending on operational priorities and Company needs. PHYSICAL REQUIREMENTS & ENVIRONMENTAL CONDITIONS: This position is primarily performed in a professional office or home-office setting. With or without reasonable accommodation, the employee must be able to: - Operate a computer and standard office equipment; - Communicate effectively in person, via telephone, and through video conferencing platforms; - Travel independently, including overnight and international trips, and travel by personal vehicle and transit systems; and - Navigate office environments and other professional settings. Additional requirements include: - Prolonged periods of sitting, standing, and walking; - Occasional lifting or carrying of items up to 20 pounds; - Ability to read, comprehend, and apply policies, procedures, and regulations written in English; - Ability to write clear, factual, and grammatically correct communications and reports in English; and - Ability to use logic and data for problem-solving and to exercise sound judgment. EQUAL EMPLOYMENT OPPORTUNITY As an equal opportunity employer, Ambros is committed to providing all applicants and employees with equal access to employment opportunities, regardless of sex, race, age, color, national origin, ancestry, disability, pregnancy, religion, genetic information, sexual orientation, transgender status, gender identity, marital status, military or veteran status, or any other characteristic protected by applicable law. All employees, officers, and representatives of Ambros are expressly prohibited from engaging in unlawful discrimination, harassment, or retaliation. Consistent with all applicable requirements, Ambros will reasonably accommodate any qualified individual with a disability if such accommodation would allow the individual to perform the essential functions of the job, unless doing so would create an undue hardship on the Company. Ambros also follows all applicable federal, state, and local laws governing work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and Immigration Reform and Control Act. Ambros is an E-Verify employer. REASSIGNMENT OF DUTIES AND AT-WILL EMPLOYMENT Nothing in this job description restricts Ambros’ right to assign or reassign duties, responsibilities, and work locations of this role at any time in its sole discretion. While this job description generally reflects Ambros’ current assessment of the essential functions for this role, it is not intended to be a complete list of the duties and responsibilities of this role, and it does not limit or restrict the duties and responsibilities that may be assigned from time to time. Employment with Ambros is “at-will,” meaning that either the Company or the employee may terminate the employment relationship at any time, with or without cause or notice, reason, or justification, subject to applicable law.

REPORTING TO: Senior Vice President Finance and Administration Finance LOCATION: Corporate Headquarters currently located in Irvine, California or remote from the Employee’s home office SALARY BAND: $215,000-$225,500 with a 20% target bonus. Final compensation will be commensurate with the candidate’s experience, education, skills, and overall alignment with the role’s requirements. EQUITY GRANT ELIGIBLE: Yes POSITION SUMMARY: Reporting to the Senior Vice President Finance and Administration Finance, the Director Financial Planning & Analysis (“FP&A”) will play a critical role in driving financial strategy, operational performance, and long-term value creation for Ambros Therapeutics, Inc. (“Ambros” or the “Company”). This individual will be responsible for leading corporate financial planning, budgeting, forecasting, and strategic analysis to support executive decision-making across clinical, research, and corporate functions. This is an individual contributor role initially and may grow into future leadership responsibilities as the Company scales toward public-company readiness. The ideal candidate will be a dynamic, experienced, execution-focused leader who can foster strong collaboration with business partners. The role requires exceptional financial acumen, analytical rigor, strong leadership insight and communication, and the ability to translate complex data into actionable insights. Success in this position requires strong communication and organizational skills, professionalism, sound judgment, and the ability to operate effectively in a fast-paced, evolving biotech environment. ESSENTIAL DUTIES AND RESPONSIBILITIES - Lead company-wide financial planning processes, including annual budgets, long-range plans, and rolling forecasts. - Partner with executive leadership and functional heads (Research and Development (“R&D”), Clinical, Regulatory, Commercial, and General and Administrative (“G&A”)) to develop and manage operating plans, drive operational decisions, and resource allocation. - Drive financial modeling to support strategic initiatives, pipeline investments, clinical development scenarios, and capital planning. - Contribute to Board of Directors and investor reporting, including preparation of financial presentations, performance analysis, and key metrics. - Ensure financial discipline through variance analysis, expense tracking, and performance monitoring across departments. - Drive additional rigor in R&D investments, and adoption of program-level reporting and planning - including clinical trial costs. - Ensure close collaboration with accounting and other teams to ensure alignment of actual results and forecasts and to support month-end close and financial reporting. - Lead FP&A financial system implementations and integrations. - Review and contribute to financing strategies, fundraising support, and scenario planning related to capital requirements and runway management. MINIMUM EXPERIENCE, EDUCATION, CERTIFICATIONS, & LICENSES: - Bachelor’s degree in Finance, Accounting, Economics, or related field required; MBA, CPA, or CFA is strongly preferred. - Minimum of 10+ years of progressive experience in financial planning and analysis, with at least 3–5 years in the biotechnology, pharmaceutical, or life sciences industry. - Strong experience in corporate financial planning, forecasting, and strategic modeling in a growth-stage or publicly traded environment. - Proven track record of supporting executive leadership with data-driven insights and strategic recommendations. - Demonstrated integrity, accountability, and commitment to financial transparency and operational excellence. SKILLS & QUALIFICATIONS: - Strategic thinker with strong analytical and problem-solving capabilities and an entrepreneurial mindset suited to a startup environment. - Superior verbal, written, and presentation communication skills, with the ability to influence senior leadership and cross-functional stakeholders. - Excellent leadership skills with demonstrated ability to manage/collaborate across scientific, clinical, and corporate functions. - Deep expertise in financial modeling, scenario analysis, budgeting, and performance management. - Strong understanding of biotech business drivers, including clinical development timelines, pipeline investment decisions, and capital planning. - Demonstrated ability to prioritize competing demands and operate effectively with minimal supervision in a rapidly changing environment. - Knowledge of internal controls, financial governance, and compliance standards relevant to the biotechnology industry. - Ability to assess financial risks, evaluate impact on corporate strategy, and support timely decision-making. - Ability to interpret complex financial and operational data, prepare executive-level reports, and communicate insights clearly. - Upholds high ethical standards and maintains integrity in all activities. - Proficient with financial planning systems, enterprise resource planning tools, and Microsoft Office Suite. WORK LOCATION AND TRAVEL REQUIREMENTS: This position is based from an Ambros corporate office or remote from the Employee’s home office, subject to Company policy and business needs. If remote, a dedicated home office space that is professional in appearance, quiet, and secure where confidential conversations can occur and a high-quality high-speed internet connection are required. Regardless of primary work location, the role requires in-person presence approximately once per month for multi-day meetings at the corporate headquarters or other designated locations, as determined by business or department priorities. Occasional domestic travel is required, including overnight stays. Travel expectations may reach up to 10%, depending on operational priorities and Company needs. PHYSICAL REQUIREMENTS & ENVIRONMENTAL CONDITIONS: This position is primarily performed in a professional office or home-office setting. With or without reasonable accommodation, the employee must be able to: - Operate a computer and standard office equipment; - Communicate effectively in person, via telephone, and through video conferencing platforms; - Travel independently, including overnight and international trips, and travel by personal vehicle and transit systems; and - Navigate office environments and other professional settings. Additional requirements include: - Prolonged periods of sitting, standing, and walking; - Occasional lifting or carrying of items up to 20 pounds; - Ability to read, comprehend, and apply policies, procedures, and regulations written in English; - Ability to write clear, factual, and grammatically correct communications and reports in English; and - Ability to use logic and data for problem-solving and to exercise sound judgment. EQUAL EMPLOYMENT OPPORTUNITY As an equal opportunity employer, Ambros is committed to providing all applicants and employees with equal access to employment opportunities, regardless of sex, race, age, color, national origin, ancestry, disability, pregnancy, religion, genetic information, sexual orientation, transgender status, gender identity, marital status, military or veteran status, or any other characteristic protected by applicable law. All employees, officers, and representatives of Ambros are expressly prohibited from engaging in unlawful discrimination, harassment, or retaliation. Consistent with all applicable requirements, Ambros will reasonably accommodate any qualified individual with a disability if such accommodation would allow the individual to perform the essential functions of the job, unless doing so would create an undue hardship on the Company. Ambros also follows all applicable federal, state, and local laws governing work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and Immigration Reform and Control Act. Ambros is an E-Verify employer.

ROLE: Vice President Regulatory Affairs DEPARTMENT: Regulatory Affairs REPORTING TO: Chief Medical Officer LOCATION: The Ambros corporate office or remote from the Employee’s home office SALARY BAND: $275,000 to $335,000 with a 30% target bonus. Final compensation will be commensurate with the candidate’s experience, education, skills, and overall alignment with the role’s requirements. EQUITY GRANT ELIGIBLE: Yes POSITION SUMMARY: Reporting to the Chief Medical Officer (“CMO”), the Vice President Regulatory Affairs will play a critical strategic, leadership, and contributor role in developing and executing regulatory strategies and tactics to support Ambros Therapeutics, Inc.’s (“Ambros” or the “Company”) clinical development programs and future commercial success. This leader will oversee all regulatory activities including submissions, interactions with health authorities, and compliance with applicable regulations in the US, and, as applicable, globally. This role will serve as the Company’s primary liaison to the U.S. Food and Drug Administration (“FDA”) and other regulatory bodies as needed and will provide cross-functional leadership to ensure that all development and registration activities align with the Company’s strategic objectives and regulatory requirements. ESSENTIAL DUTIES AND RESPONSIBILITIES - Lead the development and implementation of comprehensive regulatory strategies for Ambros’ clinical and manufacturing programs, promotional review, and regulatory filings. - Play a leadership role, along with the VP Clinical and other functions in the preparation, review, and submission of all regulatory filings including Investigational New Drug (“IND”), New Drug Application (“NDA”), and Annual Reports,” and briefing packages for Health Authority meetings. Participate in the development and review of Investigator’s Brochures (“IB”), Development Safety Update Report (“DSUR’”) and similar documents. - Serve as the company’s primary liaison with the FDA and other global health authorities; coordinate and lead key regulatory interactions and negotiations. - Direct and ensure regulatory compliance across all development stages and geographies. - Develop and update, with cross functional team input, target product profile(s) - Assess existing data from legacy companies that contribute to an NDA and assess for actions needed to gain alignment with the FDA. - Partner with cross-functional leadership (Clinical Sciences, Clinical Operations, CMC, toxicology, Safety, Medical Writing, and Quality) to ensure robust and compliant regulatory documentation and submissions. - Provide strategic input to senior management on regulatory pathways, risk assessment, and mitigation plans for global development programs. - Lead preparation for and execution of regulatory meetings - Oversee regulatory intelligence and proactively assess evolving US regulations (and global, as relevant), guidelines, and policies that impact Ambros’ programs. - Guide the development of internal regulatory procedures, Standard Operating Procedures (“SOPs”), and documentation standards in partnership with Quality. - Manage relationships with external consultants, Contract Research Organizations (“CROs”), and publishing vendors to ensure timely and accurate submission delivery. - Contribute to due diligence and regulatory strategy assessments for potential business development or partnership opportunities. - Recruit, develop, lead and mentor a high-performing Regulatory Affairs team as Ambros progresses towards an NDA. - Partner with Legal, Quality, and Clinical functions to maintain inspection readiness and ensure compliance with GXP standards. - Provide regular regulatory updates to executive management and the Board of Directors. - Other duties as assigned. MINIMUM EXPERIENCE, EDUCATION, CERTIFICATIONS, & LICENSES: - Advanced degree (PharmD, PhD, MD, or MS) in a scientific or regulatory discipline required. - Minimum of 8 to 10 years of progressively increasing responsible regulatory experience in the biotechnology or pharmaceutical industry. - Extensive experience leading IND and other regulatory submissions relevant to a medicine in late-stage development through filing, approval and commercialization. - Experience in orphan diseases and FDA-related regulations, policies and approaches on pediatric written requests is a plus. - Extensive experience with successfully interacting with FDA; experience the Division of Anesthesia, Addiction Medicine and Pain Medicine (DAAP) or General Endocrinology is a plus; experience with other global regulatory authorities is a plus. - Deep knowledge of US regulatory requirements, including FDA and International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (“ICH”) guidelines. - Proven ability to design and implement regulatory strategies for small molecules; sterile injectable experience is a plus. - Strong leadership background with experience building and managing regulatory teams in a fast-paced, matrixed environment. SKILLS & QUALIFICATIONS: - Strategic thinker with demonstrated ability to anticipate regulatory trends and shape development strategies accordingly. - Exceptional leadership, collaboration, and communication skills with ability to influence across all levels of the organization. - Strong project management capabilities and proven ability to manage multiple complex priorities simultaneously. - Expert-level knowledge of regulatory submission processes, including Electronic Common Technical Document (“eCTD”) and electronic publishing. - Excellent analytical and problem-solving skills; adept at making sound judgments under pressure. - Highly skilled at the translation of complex data into clear, credible narratives. - Superior verbal, written, and presentation communication skills in English, with the ability to engage effectively across all levels of the Company and with external stakeholders (e.g. Health Authorities, regulators, and medical and scientific experts). - Upholds high ethical standards and maintains scientific and regulatory integrity in all activities. - High degree of professionalism and commitment to operational excellence. - Must have knowledge of and be willing to comply with all regulatory requirements, compliance standards and regulations, Ambros’ SOPs and polices, and industry best practices consistent with the role and Company policies. - Ability to read and comprehend complex materials, including medical, scientific, and regulatory literature, policies, procedures, and instructions in English; write reports and memos; use logic and data to solve problems; assess needs and take appropriate actions; all with reasonable independence, business judgment, and professional discretion. - Proficiency in Microsoft Office Suite and document management systems (e.g., Veeva). WORK LOCATION AND TRAVEL REQUIREMENTS: This position is based from an Ambros corporate office or remote from the Employee’s home office, subject to Company policy and business needs. If remote, a dedicated home office space that is professional in appearance, quiet, and secure where confidential conversations can occur and a high-quality high-speed internet connection are required. Regardless of primary work location, the role requires in-person presence approximately once per month for multi-day meetings at the corporate headquarters or other designated locations, as determined by business or department priorities. Regular domestic and international travel is required, including overnight stays. Travel expectations may reach up to 20%, depending on operational priorities and Company needs. PHYSICAL REQUIREMENTS & ENVIRONMENTAL CONDITIONS This position is primarily performed in a professional office or home-office setting. With or without reasonable accommodation, the employee must be able to: - Operate a computer and standard office equipment. - Communicate effectively in person, via telephone, and through video conferencing platforms. - Travel independently, including overnight and international trips, and travel by personal vehicle and transit systems. - Navigate office environments and other professional settings. Additional requirements include: - Prolonged periods of sitting, standing, and walking. - Occasional lifting or carrying of items up to 20 pounds. - Ability to read, comprehend, and apply policies, procedures, and regulations written in English. - Ability to write clear, factual, and grammatically correct communications and reports in English. - Ability to use logic and data for problem-solving and to exercise sound judgment. EQUAL EMPLOYMENT OPPORTUNITY As an equal opportunity employer, Ambros is committed to providing all applicants and employees with equal access to employment opportunities, regardless of sex, race, age, color, national origin, ancestry, disability, pregnancy, religion, genetic information, sexual orientation, transgender status, gender identity, marital status, military or veteran status, or any other characteristic protected by applicable law. All employees, officers, and representatives of Ambros are expressly prohibited from engaging in unlawful discrimination, harassment, or retaliation. Consistent with all applicable requirements, Ambros will reasonably accommodate any qualified individual with a disability if such accommodation would allow the individual to perform the essential functions of the job, unless doing so would create an undue hardship on the Company. Ambros also follows all applicable federal, state, and local laws governing work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and Immigration Reform and Control Act. Ambros is an E-Verify employer. REASSIGNMENT OF DUTIES AND AT-WILL EMPLOYMENT Nothing in this job description restricts Ambros’ right to assign or reassign duties, responsibilities, and work locations of this role at any time in its sole discretion. While this job description generally reflects Ambros’ current assessment of the essential functions for this role, it is not intended to be a complete list of the duties and responsibilities of this role, and it does not limit or restrict the duties and responsibilities that may be assigned from time to time. Employment with Ambros is “at-will,” meaning that either the Company or the employee may terminate the employment relationship at any time, with or without cause or notice, reason, or justification, subject to applicable law.

ROLE: Clinical Outreach Specialist DEPARTMENT: Medical Affairs REPORTING TO: Vice President Medical Affairs LOCATION: Corporate Headquarters currently located in Irvine, California or remote from the Employee’s home office - Must work in Central Time Zone POSITION SUMMARY Reporting to the Vice President Medical Affairs, the Clinical Outreach Specialist will play a critical role in driving Ambros Therapeutics, Inc.’s (“Ambros” or the “Company”) patient recruitment to our clinical study as well as clinical study outreach initiatives. This individual will be responsible for contacting clinicians, clinical/referral sites, and qualified leads to share information about Ambros’ ongoing clinical study, support engagement, and connecting interested parties with study coordinators and/or Scientific Affairs Liaisons. The role requires excellent communication and organization skills, professionalism, time management, and adherence to regulatory and ethical standards governing clinical research recruitment and communications. ESSENTIAL DUTIES AND RESPONSIBILITIES - Make outbound calls to clinicians, clinical/referral sites, and potential referral leads to raise awareness and provide information on Ambros’ clinical studies in accordance with approved communication materials. - Connect clinicians to Scientific Affairs Liaison(s) in order to advance clinical trial awareness, study design, eligibility criteria, referral pathways and provide information to facilitate clinician discussions with patients who may be interested in clinical study participation. - Working in Central Time Zone - Schedule calls and virtual meetings between interested clinicians/clinical trial site staff and Scientific Affairs Liaisons, as needed. - Conduct follow-up outreach, as needed, and maintain active contact lists utilizing only Company provided systems to support ongoing recruitment, engagement, and interest in clinical programs. - Accurately document all outreach and associated interactions/outcomes, follow-ups, and contact information in the Company’s customer relationship management (“CRM”) or other tracking system. - Coordinate with Clinical Operations and broader Medical Affairs team to ensure high-quality lead management and tracking of enrollment progress. - Respond professionally to inquiries from clinicians and/or site staff, and triage appropriately. - Appropriately escalate clinician/site staff feedback, information, and challenges in a timely fashion. - Participate in regular team meetings to provide feedback on outreach effectiveness and suggest process improvements. - Maintain confidentiality of all clinical engagement information in compliance with Company policies and applicable laws. - Contribute to a positive and professional Company image during all communications and interactions. - Perform other duties as assigned, with opportunity to gain experience in other biopharmaceutical functions as available. MINIMUM EXPERIENCE, EDUCATION, CERTIFICATIONS, & LICENSES - Bachelor’s degree in communications, health sciences, marketing, or a related field preferred; associate’s degree or equivalent work experience with relevant clinical and/or pharmaceutical industry experience will be considered. - 2–4 years of experience in a call center, clinical recruitment, healthcare communications, or healthcare sales/market research role preferred. - Experience in the biotechnology, pharmaceutical, or clinical research industry strongly preferred. - Familiarity with clinical trial processes, terminology, and Good Clinical Practice (“GCP”) guidelines preferred. - Experience using customer relationship management (CRM) or clinical database systems (e.g., Salesforce, Veeva, or similar) preferred. SKILLS & QUALIFICATIONS - Superior verbal, written, and presentation communication skills in English, with multilingual ability preferred; ability to convey complex information clearly and professionally. - Strong interpersonal and relationship-building skills; comfortable speaking with physicians, advanced practice providers, nurses, and other healthcare professionals and administrative staff. - High degree of professionalism, empathy, and discretion. - Detail-oriented with strong organizational, prioritization, and time management skills. - Collaborative and supportive mindset, able to engage in team and individual performance objectives. - Elite customer service etiquette and comfortable with phone- and computer-based work in a fast-paced environment. - Ability to handle multiple priorities and meet performance metrics while adhering to all policies and compliance requirements. - Strong sense of accountability and commitment to accuracy, compliance, and ethical communication. - Proficiency in Microsoft Office Suite (Word, Excel, Outlook) and a working knowledge of CRM systems is preferred. WORK LOCATION AND TRAVEL REQUIREMENTS This position may be based at Ambros’ corporate headquarters currently located in Irvine, California or remote from the employee’s home office, subject to Company policy and business needs. If remote, a dedicated home office space that is professional in appearance, quiet, and secure where confidential conversations can occur and a high-quality high-speed internet connection are required. Regardless of primary work location, the role requires periodic in-person presence for multi-day meetings at the corporate headquarters or other designated locations, as determined by business or department priorities. Occasional domestic travel is required, including overnight stays. Travel expectations may reach up to 15%, depending on operational priorities and Company needs. PHYSICAL REQUIREMENTS & ENVIRONMENTAL CONDITIONS This position is primarily performed in a professional office or home-office setting. With or without reasonable accommodation, the employee must be able to: - Operate a computer and standard office equipment; - Communicate effectively in person, via telephone, and through video conferencing platforms; - Travel independently, including overnight trips; and - Navigate office environments and other professional settings. Additional requirements include: - Prolonged periods of sitting, standing, and walking; - Occasional lifting or carrying of items up to 20 pounds; - Ability to read, comprehend, and apply policies, procedures, and regulations written in English; - Ability to write clear, factual, and grammatically correct communications and reports in English; and - Ability to use logic and data for problem-solving and to exercise sound judgment. EQUAL EMPLOYMENT OPPORTUNITY As an equal opportunity employer, Ambros is committed to providing all applicants and employees with equal access to employment opportunities, regardless of sex, race, age, color, national origin, ancestry, disability, pregnancy, religion, genetic information, sexual orientation, transgender status, gender identity, marital status, military or veteran status, or any other characteristic protected by applicable law. All employees, officers, and representatives of Ambros are expressly prohibited from engaging in unlawful discrimination, harassment, or retaliation. Consistent with all applicable requirements, Ambros will reasonably accommodate any qualified individual with a disability if such accommodation would allow the individual to perform the essential functions of the job, unless doing so would create an undue hardship on the Company. Ambros also follows all applicable federal, state, and local laws governing work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and Immigration Reform and Control Act. Ambros is an E-Verify employer.