Senior Director, External Manufacturing Cambridge, MA Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity The Senior Director, External Manufacturing is a critical leadership role responsible for shaping and executing the external manufacturing strategy across clinical and future commercial programs. This individual will lead a global network of CDMO partners supporting a diverse and growing portfolio spanning peptides, oligonucleotides, and small molecules. As Amylyx advances toward commercialization and expands its global manufacturing footprint, this role will be instrumental in ensuring supply continuity, operational readiness, and long-term scalability. The Senior Director will partner cross-functionally to enable successful product launches, manage increasing manufacturing complexity, and build the infrastructure needed to support future growth and global expansion. Responsibilities - Provide strategic leadership and oversight of external manufacturing across clinical development and commercial supply - Establish and govern CDMO partnerships to ensure strong performance, accountability, and alignment with program objectives - Define and execute manufacturing strategies to support technology transfer, scale-up, commercialization, and lifecycle management - Establish supplier performance metrics and business review process - Mentor and build a team of relationship owners responsible for leading the internal supplier relationship teams and serving as the supplier point of contact - Ensure supply continuity through proactive risk identification, mitigation planning, and issue escalation across external partners - Oversee technology transfer, manufacturing execution, and process performance across a global network of external sites - Support commercial launch readiness, including validation, supply planning, and inspection preparedness - Partner cross-functionally with Finance, Legal, CMC, Quality, and Supply Chain to drive aligned execution - Build scalable, robust external manufacturing infrastructure, operating models, and governance frameworks to support organizational growth Required Qualifications - Bachelor’s degree in engineering, life sciences, or related field; advanced degree preferred - ~15+ years of experience in pharmaceutical or biotechnology manufacturing, including significant external manufacturing leadership - Proven track record managing CDMOs across clinical and commercial supply environments - Deep understanding of cGMP regulations, global manufacturing requirements, and regulatory expectations - Experience in manufacturing strategy, technology transfer, and commercialization activities - Demonstrated ability to lead in complex, multi-program environments and drive cross-functional alignment - Strong leadership, communication, and stakeholder management skills - Prior experience supporting commercial product launches, conducting RFPs, negotiating supply agreements, and managing high value budgets - Experience across multiple supply nodes (API, Drug Product, Packaging, Device) - Ability to travel domestically and internationally ~10% Preferred Requirements - Experience across multiple modalities (small molecule, peptide, oligonucleotide) - A track record of process scale-up, validation and continuous improvement Work Location and Conditions - At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. Preference may be given to candidates residing within or near the geographic region they support. • You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. • You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $245,000 - $276,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

At Globe Life, we are committed to empowering our employees with the support and opportunities they need to succeed at every stage of their career. We take pride in fostering a caring and innovative culture that enables us to collectively grow and overcome challenges in a connected, collaborative, and mutually respectful environment that calls us to help Make Tomorrow Better. Role Overview: Could you be our next Senior Director, Onboarding? Globe Life is looking for a Senior Director, Onboarding to join the team! This role is responsible for supporting key accounts and recruiting leadership by driving production growth, agent activation, field training, marketing execution, and operational support while collaborating with key account leaders, recruiting teams, lead vendors, and internal departments to remove barriers to sales and accelerate agents into production. You will manage day-to-day account servicing, reporting, bonus tracking, portal and CRM troubleshooting, onboarding support, and the creation and delivery of training webinars, seminars, and promotional campaigns. This position also offers the opportunity to lead as a player-coach, managing key account managers and early producers, mentoring recruiting team members on sales fundamentals, and developing scalable systems, automations, and marketing initiatives that support both recruiting and production results. This is a remote/work-from-home position. What You Will Do: - Support assigned key accounts by responding to production, recruiting, and service requests, and coordinate solutions with internal partners to remove barriers to sales. - Manage a portfolio of key accounts while providing direct production coaching and servicing support to first-year producers and key account managers. - Maintain, update, and communicate key performance metrics by managing tracking tools and preparing reports for leadership. - Calculate, audit, and inspect quarterly bonus and incentive amounts to ensure accuracy, accountability, and timely payout support. - Partner with recruiting teams to transition newly appointed agents into early production by clarifying expectations, connecting agents to training resources, and monitoring activation progress. - Facilitate agent onboarding by guiding agents through portal registration and related systems, and troubleshooting access, credential, and navigation issues. - Train and coach agents, recruiters, and field leaders on sales and production fundamentals through one-on-one support, group sessions, webinars, and follow-up coaching. - Plan, create, market, and deliver recurring training webinars and live seminars, including coaching team members on effective presentation skills, content flow, and audience engagement. - Create marketing materials, promotional campaigns, sales support content, and promotional videos to support product launches, recruiting initiatives, and major field events. - Speak and present at major company events (e.g., convention, recognition events, and other large meetings) to support training, motivation, and strategic initiatives. - Work with lead vendors to define quality expectations, improve lead performance, negotiate terms, and identify alternative lead sources. - Build, manage, and optimize automated drip campaigns and workflows for recruiting prospects and agents using approved CRM/marketing tools, including administration, troubleshooting, and process improvements. - Write and deploy professional HTML email templates and communications to improve message quality, branding consistency, and campaign performance. - Drive attendance and engagement for training webinars and seminars through coordinated marketing outreach, invitations, reminders, and follow-up campaigns. - Serve as a liaison between the field and home office partners to escalate and resolve agent-impacting issues while building strong cross-functional relationships. - Support product launches and field rollouts by developing communication pieces, training content, and implementation support for agents and leaders. - Document common issues, solutions, and process improvements, and share updates with stakeholders to reduce repeat problems and improve the agent experience. - Demonstrate the business impact and ROI of recruiting efforts by tracking outcomes and communicating how recruiting activity contributes to production and team performance. - Perform administrative and coordination duties required to operate the function effectively. What You Can Bring: - High school diploma or equivalent (GED) required; college coursework or associate degree preferred. - Equivalent combination of education, training, and directly relevant experience will be considered. - Completion of company/industry training related to Medicare products, enrollment periods, compliance, and sales support processes preferred. - 5+ years of experience in insurance sales support, key account support, agency operations, recruiting support, field training, marketing operations, or a related role. - Experience supporting agent onboarding, appointment, and activation processes, including portal/system troubleshooting and issue resolution. - Demonstrated ability to manage and coach producers, account managers, and/or support team members to improve production outcomes. - Experience creating and delivering training webinars, seminars, and presentations, as well as marketing materials and campaigns that drive attendance, engagement, recruiting, and production growth. - Experience working with lead vendors, evaluating lead quality/performance, and identifying alternative lead sources. - Experience tracking, analyzing, auditing, and communicating performance results (e.g., production, recruiting, incentives/bonus metrics) to leaders and stakeholders. - Experience with CRM management, workflow automation, drip campaigns, or related marketing/operations systems support. - Medicare knowledge and ability to support training on enrollment periods, penalties, and product basics strongly preferred. - Valid driver's license with ability to travel locally; Life and Health insurance license required. - Ongoing continuing education for Medicare preferred. - Thorough knowledge of the insurance sales and agent lifecycle (recruiting, appointment, onboarding, activation, and ongoing production support). - Working knowledge of Medicare products (Medicare Supplement/Medigap, Medicare Advantage, Part D), enrollment periods (IEP, AEP, OEP, SEP), and common late enrollment penalties. - Strong analytical, auditing, and reporting skills, including the ability to calculate and inspect incentive/bonus amounts and communicate insights to leaders. - Strong leadership, coaching, and communication skills, including facilitation and presentation skills for webinars, seminars, and major events. - Demonstrated problem-solving mindset with the ability to troubleshoot portal, CRM, and process issues and drive resolution across departments. - Experience developing marketing and sales enablement content, including training materials, promotional videos, campaign messaging, and HTML email communications. - Working knowledge of CRM platforms, marketing automation, drip campaigns, and data-driven campaign execution. - Vendor management and negotiation skills, including lead source evaluation and quality/performance improvement. - Strong project management and prioritization skills in a fast-paced, multi-stakeholder environment. - Proficiency with Microsoft Office (Excel, PowerPoint, Outlook) and comfort with web-based systems, portals, and reporting tools. - Strong public speaking skills with the ability to present clearly and professionally to small and large audiences, including leadership and field teams. Applicable To All Employees of Globe Life Family of Companies: - Reliable and predictable attendance of your assigned shift. - Ability to work full time and/or part time based on the position specifications. How Globe Life Will Support You: Looking to continue your career in an environment that values your contribution and invests in your growth? We've curated a benefits package that helps to ensure that you don’t just work, but thrive at Globe Life: - Competitive compensation designed to reflect your expertise and contribution. - Comprehensive health, dental, and vision insurance plans because your well-being is fundamental to your performance. - Robust life insurance benefits and retirement plans, including company-matched 401k and pension plan. - Paid holidays and time off to support a healthy work-life balance. - Parental leave to help our employees welcome their new additions. - Subsidized all-in-one subscriptions to support your fitness, mindfulness, nutrition, and sleep goals. - Company-paid counseling for assistance with mental health, stress management, and work-life balance. - Continued education reimbursement eligibility and company-paid FLMI and ICA courses to grow your career. - Discounted Texas Rangers tickets for a proud visit to Globe Life Field. Opportunity awaits! Invest in your professional legacy, realize your path, and see the direct impact you can make in a workplace that celebrates and harnesses your unique talents and perspectives to their fullest potential. At Globe Life, your voice matters.

Coupa makes margins multiply through its community-generated AI and industry-leading total spend management platform for businesses large and small. Coupa AI is informed by trillions of dollars of direct and indirect spend data across a global network of 10M+ buyers and suppliers. We empower you with the ability to predict, prescribe, and automate smarter, more profitable business decisions to improve operating margins. Why join Coupa? 🔹 Pioneering Technology: At Coupa, we're at the forefront of innovation, leveraging the latest technology to empower our customers with greater efficiency and visibility in their spend. 🔹 Collaborative Culture: We value collaboration and teamwork, and our culture is driven by transparency, openness, and a shared commitment to excellence. 🔹 Global Impact: Join a company where your work has a global, measurable impact on our clients, the business, and each other. Learn more on Life at Coupa blog and hear from our employees about their experiences working at Coupa. The Impact of a Sr. Account Director, Enterprise at Coupa: As an Enterprise Account Director at Coupa, you will drive our growth by prospecting, qualifying, pursuing, and closing opportunities within strategic accounts with revenues over USD 1bn. Your focus will be on targeting new logo prospects and building strong relationships with key decision-makers such as CPOs, CFOs, CIOs, and other customer stakeholders and influencers. By developing trusted advisor-level relationships, you will position Coupa as the preferred partner and create new business opportunities in collaboration with our digital transformation partners. Your contributions as an Enterprise Account Director will directly impact our success in expanding our market presence and driving revenue growth. Through your strategic approach and deep understanding of our customers' needs, you will establish Coupa as the go-to solution for their business challenges. Your ability to foster trusted relationships with senior executives and key stakeholders will drive new business opportunities and solidify Coupa's position as the Total Spend Platform leader. Join us in shaping the future of enterprise accounts and play an instrumental role in driving the growth and success of Coupa on a global scale. What You’ll Do - Prospecting, building pipeline and selling Coupa cloud-based spend management solutions - Engaging with C-level professionals to position Coupa’s strategic value proposition and lead large six-figure plus deals to closure - Collaborating with customers and internal teams to build joint vision roadmaps outlining the value that Coupa will deliver - Creating & maintaining actionable account plans to guide and develop strategies and identify new business opportunities - Providing accurate forecasts and monthly reports to the sales manager to communicate the health of the sales pipeline, significant market trends, and any potential risks that may impact the ability to hit targets What You Will Bring to Coupa - Consistent track record of exceeding sales quota in a SAAS B2B Software environment - Proven track record of successfully selling to and influencing C-level executives at the Enterprise level - Strong organizational capability and experience in enterprise account planning - Demonstrated ability to sell business value to Finance and Business customers using ROI and TCO models - Cross-functional leadership skills, working effectively with diverse teams, including Account Development and Solutions Consulting teams to deliver successful business outcomes Coupa complies with relevant laws and regulations regarding equal opportunity and offers a welcoming and inclusive work environment. Decisions related to hiring, compensation, training, or evaluating performance are made fairly, and we provide equal employment opportunities to all qualified candidates and employees. Please be advised that inquiries or resumes from recruiters will not be accepted. By submitting your application, you acknowledge that you have read Coupa’s Privacy Policy and understand that Coupa receives/collects your application, including your personal data, for the purposes of managing Coupa's ongoing recruitment and placement activities, including for employment purposes in the event of a successful application and for notification of future job opportunities if you did not succeed the first time. You will find more details about how your application is processed, the purposes of processing, and how long we retain your application in our Privacy Policy.

Role Description Reporting to the Executive Director, CMC Regulatory Affairs, the Senior Manager or Associate Director of CMC Regulatory Affairs will lead and participate in regulatory activities associated with IND/CTA development and maintenance for support of new and ongoing clinical trials, as well as planning for future MAA/NDA/BLA(s). This role requires an independent, self-directed, and highly motivated regulatory professional. - Deliver CMC regulatory support through QC review of submission components, including CMC documents, labeling, application forms, supporting GMP documentation, cover letters and verification of submission links, ensuring completeness, consistency, and compliance with regulatory requirements. - Prepare and/or review CMC regulatory documents and submissions to support product development (e.g. ND/CTAs, DSUR, health authority briefing document, iPSP/PIP, NDA/MAA). - Provide oversight of regulatory submission content and planning, to assure technical accuracy, compliance, and completeness. - Assess proposed CMC changes (e.g., manufacturing processes, analytical methods, specifications, manufacturing sites, container closure systems, stability programs, and suppliers) and support development of appropriate global regulatory filing strategies. - Collaborate cross-functionally on the eTMF processes and compliance alignment. - Represent regulatory on study and program teams throughout study conduct and product development. - Support or lead development of global regulatory submissions, including requests from regulatory authorities relating to clinical trials, and responses to health authority requests for information, as required. - Review relevant clinical and CMC documents (protocol, informed consent form, investigator’s brochure, and site quality documentation, and required regulatory forms) for regulatory compliance and consistency across submission components. - Maintain current knowledge of US and international CMC regulation requirements that apply to company products and processes. - Support or lead development of internal Erasca SOPs and processes, as needed. - May support other global submission activities as appropriate, independently or in collaboration with the Regulatory Affairs project lead. - Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations. Qualifications - Undergraduate degree required; advanced degree preferred. - 5+ years of experience in pharmaceutical or biotech regulatory affairs or related areas, including regulatory affairs for oncology products. - Ability to translate regulatory requirements into practical workable plans. - Diverse experience with regulatory activities including creation of systems and processes to support efficient and high quality submission of documents to regulatory bodies. - Strong organizational skills that reflect the ability to perform and prioritize multiple tasks with excellent attention to detail. - Ability to build strong relationships with co-workers of various backgrounds and expertise. - Demonstrated ability to achieve high performance goals and meet deadlines in a fast-paced environment. - Effective interpersonal and communication skills; must be a collaborative team player with a can-do attitude and the ability to identify and implement creative solutions to complex technical problems. - Strong learning orientation, curiosity, and commitment to science and patients. Requirements - The anticipated salary range for this position is $175,000 to $205,000. - The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. - In addition to base salary, the hired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price. Benefits - Paid Time Off, Holiday, and Sick Leave - Medical, Dental and Vision Plans - Short- and Long-Term Disability - Basic and Voluntary Life/AD&D Coverage - Flexible Spending Accounts (FSA, HSA, and Commute) - Critical Illness and Accident Coverage - Pet Insurance - Employee Assistance Program - 401(k) Plan with Erasca contribution - Opportunity to participate in an Employee Stock Purchase Program Company Description Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.