Role Description The Medical Director will lead the design, execution, and analysis of clinical trials in the Ophthalmology therapeutic area, with a focus on retina programs. This role provides strategic and operational clinical leadership across cross-functional study teams and serves as a key medical expert internally and externally. Major Duties & Responsibilities - Lead clinical strategy and execution for ophthalmology trials, including protocol development, study oversight, and data interpretation. - Serve as medical monitor for clinical studies, ensuring patient safety and data integrity. - Author and review clinical documents including protocols, IBs, ICFs, INDs, CSRs, and regulatory submissions. - Collaborate with cross-functional teams (clinical operations, regulatory, biometrics, safety, CMC, commercial) to drive program success. - Engage with external experts, organize advisory boards, and contribute to scientific and medical communications. - Identify and mitigate clinical and programmatic risks. - Support portfolio development and evaluation of new clinical opportunities. - Represent the company in regulatory and scientific forums as needed. Qualifications - Medical Degree (M.D.), OD, PhD, PharmD or equivalent - Residency training in Ophthalmology with a preference for subspecialty training in retina - Board certification a plus - Retina fellowship training a plus - 5+ years of clinical ophthalmology research in the biopharmaceutical industry - Experience with Phase 3 retina clinical trials - Experience with gene therapy a plus - Experience in other phases (Phase 1, 2, 4) of clinical research a plus - Experience with NDA/BLA/MAA submission a plus - Experience writing clinical research protocols and acting as a medical monitor - Experience in data analysis, data interpretation, and medical writing - Knowledge of ICH-GCP and FDA regulatory guidelines - Knowledge of international regulatory guidelines a plus - Effective written and verbal communication skills, including public speaking Requirements - Travel: 15% - Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. - Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. - Talking: Expressing or exchanging ideas by means of the spoken word. - Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. - Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Benefits - Base salary compensation range: $278,000 - 310,000 - Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. Company Description 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.

• Develops professional relationships and engages with national and regional SLs to ensure access to company-approved medical and scientific information on areas of therapeutic interest and Company products • Conducts peer-to-peer scientific discussions and maintains a reliable presence with those SLs to ensure they have a medical contact within the company • Addresses scientific questions and directs SL inquiries on issues outside of scope (e.g., grants) to appropriate company resources consistent with applicable policies • Maintains current knowledge and comprehension of dynamic scientific and clinical environment in the Company's Areas of Interest (AOI) for your specific therapeutic area • Initiates discussions with SLs and/or potential investigators that include scientific/data exchange within our AOI to determine the alignment with our research strategies, studies concepts, scientific merit, and qualifications for a specific compound or trial • Recommends study sites and identifies potential investigators to participate in phase II-IV clinical development programs, conducts Site Initiation Visits (SIVs), and detects barriers to patient enrollment and retention efforts to achieve study milestones • Engages in scientific congresses and medical meetings, facilitates scientific and data exchange for both Company and competitor data • Gathers feedback, data, or information during routine activities that can help the company better comprehend medical or scientific needs, priorities, or concerns of SLs and/or patients

• Develops professional relationships and engages with national and regional SLs to ensure access to company-approved medical and scientific information on areas of therapeutic interest and Company products • Conducts peer-to-peer scientific discussions and maintains a reliable presence with those SLs to ensure they have a medical contact within the company • Addresses scientific questions and directs SL inquiries on issues outside of scope (e.g., grants) to appropriate company resources consistent with applicable policies • Maintains current knowledge and comprehension of dynamic scientific and clinical environment in the Company's Areas of Interest (AOI) for your specific therapeutic area • Initiates discussions with SLs and/or potential investigators that include scientific/data exchange within our AOI to determine the alignment with our research strategies, studies concepts, scientific merit, and qualifications for a specific compound or trial • Enhances the comprehension of the scientific foundations and goals of investigator-sponsored research • Identifies barriers to patient enrollment and retention efforts to achieve study milestones • Recommends study sites and identifies potential investigators to participate in phase II-IV clinical development programs, conducts Site Initiation Visits (SIVs), and detects barriers to patient enrollment and retention efforts to achieve study milestones • Addresses questions from investigators and provides information regarding participation in Company-sponsored clinical studies

• Engage with national and regional Scientific Leaders to ensure access to company-approved medical and scientific information • Conduct peer-to-peer scientific discussions • Address scientific questions • Initiate discussions with Scientific Leaders and potential investigators for research alignment • Recommend study sites and potential investigators for clinical development programs • Engage in scientific congresses and medical meetings