• Develop research methods and data analysis plans related to healthcare utilization, cost trends, financial forecasting, member, and provider experience. • Expertly use appropriate software tools to retrieve, edit and tabulate data from various databases and files. • Conduct descriptive, prescriptive, predictive analyses. • Summarize complex data for leadership in the appropriate form (e.g., statistical summaries, narratives, charts, tables, graphs, etc.) to convey meaning, significance, and actionable information. • Contribute/Lead in the research and development of models, algorithms, and analysis tools to mature the use and creation of self-service data products at CareOregon. • Develop visual reporting (e.g., dashboards, scorecards, etc.) using data visualization tools such as Tableau when appropriate. • Develop appropriate subject matter, domain expertise and serve as an expert resource. • Collaborate with other subject matter experts to identify opportunities for building repeatable data products. • Collaborate with business teams to understand business needs and to illicit and document requirements for analytics, algorithms, models, etc. • Develop reporting tools to comply with regulatory reporting requirements. • Review and assess completeness, validity, and reliability of internal data used for analysis and reporting. • Create and maintain technical documentation such as data dictionaries, business glossaries, metric definitions, and other data resources. • Thoroughly document models, algorithms, data products, processes and any analysis, reports developed. • Contribute to, and actively participate in, community of practice to improve the skills and capabilities of other analysts at CareOregon. • Assist with, prepare, and/or deliver presentations to community groups, regulatory agencies, leadership, and other teams as needed.

Role Description We’re looking for a Senior Scientist, Study Toxicologist on the Nonclinical Safety team to help us expand what’s possible for patients with serious diseases. Reporting to the Associate Director, Toxicology Study Operations you’ll play a critical role in collaborating with project toxicologists and managing the outsourcing, design, and oversight of safety pharmacology and toxicology studies at contract research organizations (CROs). What You'll Do: - Collaborate with toxicology project leads and subject matter experts (e.g., discovery, bioanalysis, pharmacokinetics, CMC) to design safety pharmacology and toxicology studies, aligning with company objectives and regulatory standards. - Serve as the primary sponsor representative for CROs, handling all aspects of study outsourcing, including requesting quotes, negotiating contracts, and managing study timelines. - Oversee the design, execution, and data interpretation of nonclinical safety studies conducted at CROs, ensuring robust and high-quality data generation. - Review study reports and SEND datasets to ensure quality, timeliness, and readiness for regulatory submissions. - Effectively communicate study findings to toxicology project leads and senior management, addressing and resolving any study-related issues promptly. - Contribute to the preparation, review, and/or QC of nonclinical sections in regulatory submission documents (e.g., IBs, INDs, CTAs, NDAs, BLAs, MAAs, PIPs, Scientific Advice, annual reports, briefing documents) as needed. - Participate in issue-resolution teams, providing scientific guidance to address toxicology-related challenges and drive effective problem-solving. - Develop and enhance departmental SOPs and best practice documents to improve study operations and ensure regulatory compliance. Qualifications - You have a PhD or an MS and 3 years of toxicology experience or a BS and 5 years of toxicology experience in the pharmaceutical/biotechnology industry or at CROs. - Expertise overseeing safety pharmacology studies. - Proven track record of successfully directing and/or monitoring toxicology studies across various modalities, including small molecules, biologics, antisense oligonucleotides, and gene therapies. - Advanced knowledge of toxicology in support of drug development. - In-depth understanding of GLP regulations and regulatory guidance for nonclinical evaluations. Requirements - 5+ years of hands-on experience as a study director and/or monitor in toxicology (nice to have but not required). - Interest in expanding your experience with general toxicology studies. - Demonstrated enthusiasm for scientific research and a commitment to maintaining high-quality standards in toxicology study operations. - Strong strategic thinking, critical analysis, and leadership capabilities. - Self-motivated to meet performance objectives and to prioritize job-related tasks. - Ability to adapt to dynamic project needs and manage studies across different time zones. - Excellent interpersonal, communication, and negotiation skills, with a collaborative mindset. - Willingness and flexibility to travel on business to CROs. Benefits - Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP). - Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration. - 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance. - Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities. - Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back. Company Description At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

• Conduct orientation to medical records for new abstraction team members • Manage the green-lighting process and completion of on-going IRR, identifying any performance concerns in collaboration with the Clinical Services Lead and escalating concerns to Senior Manager/Manager • Effectively manage the fallout review/exception/occurrence reporting and Second Look process, ensuring accurate reporting, and partnering with the Clinical Services Lead to ensure partner notification and review • Provide follow-up/feedback/education to the project team on quality issues or trends identified during greenlighting, on-going IRR, second looks, pre-submission cleaning, review of project quality trends, etc. • Collaborate with Clinical Services Lead and Senior Manager/Manager to identify quality trends in the data with respect to internal team performance, and also identify hospital quality trends to share with partners • Mentor, train and provide guidance to new hires during the onboarding process at assigned facilities • Maintain and share abstraction team support documents, including Measure Detail and Documentation Clarification Forms, regularly updating with new measures and/or partner EMR changes • Complete the 1st pass of pre-submission clean-up, update cases when missing documentation is provided • Subject matter expert in assigned registry or measure. Provide expert abstraction support – 15% - 20% abstraction • Other quality tasks, as assigned • Attend new partner orientation in order to orient new team members as added to the project • Work closely with the Clinical Services Lead, as needed, for case-specific questions • Other partner tasks, as delegated by the Clinical Services Lead or the Senior Manager/Manager

• Work closely with CEO to help shape strategy and build data into all workflows • Own the data function end-to-end while leading a high-leverage team • Push what's possible with AI and help transform the company into a closed loop system • Build and ship AI tools, leading high-leverage investigations and audits