• Serve as the lead clinical liaison for partner providers across multiple regions, representing Cadence’s care model with clinical authority and consistency • Partner with PRMs on clinic visits and ongoing relationship management to strengthen long-term program engagement • Communicate the clinical rationale behind Cadence’s care protocols, data practices, and service offerings • Lead onboarding and training for new clinic partners • Resolve provider concerns with empathy, clinical judgment, and structured follow-through to deepen partner relationships • Translate field insights into actionable intelligence for clinical, product, and engineering teams, directly informing service improvements and care model refinement

Title: Medical Director, Clinical Trial Physician - Neurology (Remote) - FSP Location: Remote United States of America Full time Remote Join Thermo Fisher Scientific as a Medical Director/Clinical Trial Physician(FSP) based in the United States and be part of a world-class organization conducting groundbreaking research. Ideal candidate location is Eastern or Central Time Zone. This position is fully remote, benefit eligible with travel in a 10-20% range(international maybe required). *Must be legally authorized to work in the United States or Canada without sponsorship. *Must be able to pass a comprehensive background check, which includes a drug screening(where applicable). *East coast time zone is preferred, or ability to work EST hours Client Dedicated Role: Our client, a global mid-sized biotech company, focuses on developing innovative treatments for patients with autoimmune diseases. This fast-growing, international organization has a strong scientific foundation. If you're looking for a place where your work, in partnership with others, can have real impact—and where you're encouraged to challenge yourself and contribute to breakthrough solutions , the Medical Director/Clinical Trial Physician could be a great fit. Discover Impactful Work: Provides clear medical leadership in the Study team, working in close collaboration with the other members of this cross functional team, in order to provide reliable, high quality study data within time and budget. A day in the Life: - Provide medical leadership to the study teams, including creating clinical trial protocols while implementing the latest scientific information, contribute to site selection, contribute to review and approval of study protocols and amendments, Clinical Study Reports (CSRs), Informed Consent Forms (ICFs), Case Report Forms (CRFs), protocol deviation decisions and other clinical documents as required for the conduct of clinical trials - Real time Medical Monitoring of clinical studies: ensure medical validity of each individual primary endpoint as well study subject safety, while ensuring medical issues are identified early. Pro-active escalation and correction of issues in consultation with the Global Medical Indication Lead - Interpret the clinical trial data for regulatory documents (e.g. CSR, INDs, Annual Reports, NDAs, MAAs, etc.), manuscripts, and other publications as required, in consultation with the Indication Lead - Medical point of contact for all internal and external stakeholders: Interact with the investigators as needed, answer questions of IRBs and Health Authorities, prepare and present material to the study executive and independent safety committee if applicable; medical training of site staff at Investigator meetings; CRA training in new indications - Ensure study compliance for all medical aspects by understanding and applying all relevant SOPs and GCP - Closely collaborate with the cross functional study team members in order for medical risks, issues, and results to be clear to all involved parties - In case more than 1 physician is working on the protocol, a primus inter pares will be appointed, and they will ensure that answers to questions from sites /IRBs RAs, eligibility and protocol deviation decisions will be harmonized across medics Keys to Success: Education - Medical Doctor or equivalent degree required. Board certification(s) are preferred - Specialty education(e.g. residency/fellowship) required in neurology. This should be accompanied by patient treatment and/or research experience - 1-3 years of industry experience required. Experience should be in clinical development in a Pharmaceutical, Biotech or CRO organization - Neurologists with expertise in Pediatric Neurology or Neuromuscular diseases are highly preferred. Knowledge, Skills, Abilities - Excellent English, both written and spoken is a must, as well as ability to travel - Shown understanding and experience with NDA submission process - Shown understanding of regulatory guidelines for adverse event reporting - Proven interpersonal skills enabling to lead a study team, while recognizing individual expert competencies, providing medical advice and evaluations exercising judgment in which issues need to be escalated immediately - Pro-active problem solver with negotiation skills, remaining sensitive to the different cultural needs in a global organization - Strong communication skills to ensure close collaboration with the cross functional team members so that study plans and status are transparent, and that risks, issues, and results are clear to all involved parties. A matrix structure requires additional skills in gathering decision information, negotiation and communicating decisions and actions Benefits We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!

Role Description The Medical Director provides physician support to Enterprise Clinical Services operations, the organization responsible for the initial clinical review of service requests for Enterprise Clinical Services. The Medical Director collaborates with Enterprise Clinical Services leadership and staff to establish, implement, support, and maintain clinical and operational processes related to benefit coverage determinations, quality improvement, and cost effectiveness of service for members. The Medical Director's activities primarily focus on the application of clinical knowledge in various utilization management activities with a focus on pre-service benefit and coverage determination or medical necessity (according to the benefit package), and on communication regarding this process with both network and non-network physicians, as well as other Enterprise Clinical Services. The Medical Director collaborates with a multidisciplinary team and is actively involved in the management of medical benefits. The collaboration often involves the member’s primary care provider or specialist physician. It is the primary responsibility of the Medical Director to ensure that the appropriate and most cost-effective quality medical care is provided to members. You’ll enjoy the flexibility to work remotely from anywhere within the U.S. as you take on some tough challenges. Primary Responsibilities: - Conduct coverage reviews based on individual member plan benefits and national and proprietary coverage review policies, render coverage determinations. - Document clinical review findings, actions, and outcomes in accordance with policies, and regulatory and accreditation requirements. - Engage with requesting providers as needed in peer-to-peer discussions. - Be knowledgeable in interpreting existing benefit language and policies in the process of clinical coverage reviews. - Participate in daily clinical rounds as requested. - Communicate and collaborate with network and non-network providers in pursuit of accurate and timely benefit determinations for plan participants while educating providers on benefit plans and medical policy. - Communicate and collaborate with other internal partners. - Call coverage rotation. Qualifications - M.D or D.O. - Board certification in General Surgery. - Active unrestricted license to practice medicine. - 5+ years of clinical practice experience after completing residency training. - Sound understanding of Evidence Based Medicine (EBM). - Solid PC skills, specifically using MS Word, Outlook, and Excel. - Proven ability to participate in call coverage rotation. Requirements - Experience in utilization and clinical coverage review. - Proven excellent oral, written, and interpersonal communication skills, facilitation skills. - Proven data analysis and interpretation aptitude. - Proven innovative problem-solving skills. - Proven excellent skills for both clinical and non-clinical audiences. - Reside in either MST or PST zone or willing to work those hours. Benefits - Comprehensive benefits package. - Incentive and recognition programs. - Equity stock purchase. - 401k contribution (all benefits are subject to eligibility requirements). Application Deadline This will be posted for a minimum of 2 business days or until a sufficient candidate pool has been collected. Job posting may come down early due to volume of applicants.

Senior Medical Science Liaison, Rare Diseases - West locations Remote time type Full time job requisition id R11891 As an integral member of Otsuka’s Rare Diseases Business Unit within Medical Affairs, the Senior Medical Science Liaison (Sr. MSL), Rare Diseases, executes national medical strategies in the field and is responsible for the development and execution of regional medical business plans. The Sr. MSL identifies, prioritizes, and engages stakeholders and accounts with both regional and national importance that are critical to Otsuka’s rare disease objectives. The Sr. MSL is a credible scientific partner who provides clinical, scientific, and healthcare landscape expertise related to rare disease states, emerging data, and therapeutic opportunities across the product lifecycle, including pre-launch, launch, and post-launch phases. This field-based role engages highly specialized stakeholders—including key opinion leaders (KOLs), investigators, healthcare providers, advocacy organizations, and multidisciplinary care teams—to advance patient outcomes aligned with Otsuka’s overarching objectives. In collaboration with internal partners, the Sr. MSL develops and executes regional medical business plans and associated tactics aligned with national medical strategy to address evolving customer and account needs. The Sr. MSL is responsible for the scientific and educational needs of assigned customers and accounts and may support multiple disease areas or assets within the rare disease portfolio. This individual engages in broad clinical and scientific discussions that impact patient care, account readiness, launch preparedness, and long-term medical strategy, generating high-quality customer insights shared across Medical Affairs and the broader organization. These roles will support rare disease programs including FUS ALS, PKU, and other LCM indications. Unlike a traditional field medical model, these positions will operate across broad geographic regions, with a limited number of field medical colleagues covering the entire United States. As a result, the role is highly account-focused, with particular emphasis on Centers of Excellence, specialized referral centers, and other strategically important rare disease accounts. The Sr. MSL collaborates, as appropriate, with Global Medical Strategy, Advocacy, and Commercial partners in support of enterprise rare disease objectives, while operating in full compliance with all applicable medical, legal, and regulatory requirements. Key Activities and Responsibilities - Execute national medical strategies in the field while identifying, prioritizing, and engaging stakeholders and accounts with regional and national significance. - Develop, implement, and adapt regional medical business plans aligned with national medical strategy and tailored to assigned regions, priority accounts, and specialized stakeholder groups. - Contribute clinical and scientific expertise to regional planning and execution activities that address customer and account challenges, opportunities, and unmet needs across pre-launch, launch, and post-launch phases. - Build, cultivate, and sustain strong external relationships with key scientific and medical stakeholders to maintain a deep understanding of healthcare trends, disease-state dynamics, care pathways, treatment readiness, and unmet needs. - Engage priority stakeholders across rare disease accounts, including KOLs, investigators, healthcare providers, key decision-makers, patient advocacy organizations, and multidisciplinary care teams. - Develop and maintain a comprehensive understanding of the regional and national rare disease landscape, including Centers of Excellence, referral pathways, diagnostic and treatment patterns, and account-specific needs, ensuring alignment with Otsuka’s patient-centric strategy. - Serve as a trusted source of evidence-based scientific information and collaborate with healthcare professionals to identify practical, real-world approaches to improving patient outcomes. - Contribute to business objectives beyond the assigned region and provide meaningful impact across the broader Medical Affairs organization. - Establish and maintain strong internal partnerships across Rare Diseases Medical Affairs and cross-functional teams to ensure an enterprise mindset when engaging customers and strategic accounts. - Be accountable to Rare Diseases Medical Affairs leadership for the effective execution of regional medical business plans and tactics within established timelines. - Lead special projects as requested by management and assume incremental leadership or point roles within Medical Affairs. - Disseminate disease-state, clinical, scientific, and healthcare landscape information in alignment with medical priorities and product lifecycle needs. - Support clinical and data-focused training for approved speakers and contribute to scientific education initiatives, as appropriate and in compliance with company policy. - Serve, where appropriate and compliant, as part of Otsuka’s speaker bureau or scientific education programs supporting disease-state and product-related education. - Collect, synthesize, and submit high-quality medical insights to inform decision-making, evidence-generation priorities, launch readiness, launch optimization, and healthcare solution development. - Support clinical trials and medical collaboration activities, including registrational studies, post-marketing research, investigator-sponsored research, and other medical initiatives; provide field-based clinical input on site identification, feasibility, account readiness, and study execution. - Participate in mentoring and peer development activities, including onboarding and support of new hires and sharing of best practices. - Support additional organizational activities, including Safety and Pharmacovigilance investigations, internal medical education, and Medical Affairs excellence initiatives through mentorship and knowledge sharing. - Collaborate, as appropriate, with Global Medical Strategy, Advocacy, and Commercial partners to support pre-launch planning, launch execution, and post-launch medical strategy, while maintaining strict compliance boundaries and non-promotional standards. Therapeutic Area / Stakeholder focus (Subject to change as the Rare Diseases Business Unit evolves) The Senior Medical Science Liaison, Rare Diseases, supports highly specialized stakeholder groups that differ from traditional MSL customer profiles and may include, but are not limited to: - FUS ALS: Neurologists, neuromuscular specialists, ALS specialists and ALS centers, investigators, multidisciplinary care teams, and relevant advocacy organizations - PKU: Metabolic geneticists, inherited metabolic disease specialists, dietitians, specialized treatment centers and care teams, investigators, and relevant advocacy organizations This role engages stakeholders through a strategic, account-based approach, with a strong emphasis on Centers of Excellence and specialized referral or treatment centers. Qualifications: - MD, DO, PharmD, or PhD in life sciences required - Prior experience as a Medical Science Liaison or in other Medical Affairs roles within the pharmaceutical or biotechnology industry, or an equivalent combination of education and experience, required - Rare disease experience strongly preferred - Prior experience in neurology, neuromuscular disease, ALS, metabolic disorders, PKU, inherited metabolic disease, or other highly specialized therapeutic areas preferred - Deep understanding of healthcare systems, Centers of Excellence, and patient care delivery, with experience engaging healthcare professionals and decision-makers - Minimum of 5+ years of relevant experience within pharmaceutical industry Medical Affairs - Strong business acumen; understanding of industry dynamics, Otsuka’s business model and value proposition, competitive landscape, and market factors, with a focus on driving improved patient outcomes - Exceptional communication and collaboration skills, demonstrating professional maturity, confidence, and credibility - Proven conflict resolution skills and ability to work effectively in cross-functional and fast-paced environments - Demonstrated leadership skills with the ability to lead teams and projects strategically - Ability to distill and communicate complex scientific and business information clearly and concisely - Strong understanding of legal, regulatory, and compliance requirements governing Medical Affairs - Ability to operate effectively in ambiguous environments across multiple phases of the product lifecycle - Demonstrated behaviors aligned with the Otsuka Corporate Brand: Perseverance, Unconventional Thinking, and Humility - Ability to travel up to 70% by air or car, depending on regional coverage needs - Preferred residence in a major metropolitan area or airport hub within the assigned region Competencies Accountability for Results - Stay focused on key strategic objectives, be accountable for high standards of performance, and take an active role in leading change. Strategic Thinking & Problem Solving - Make decisions considering the long-term impact to customers, patients, employees, and the business. Patient & Customer Centricity - Maintain an ongoing focus on the needs of our customers and/or key stakeholders. Impactful Communication - Communicate with logic, clarity, and respect. Influence at all levels to achieve the best results for Otsuka. Respectful Collaboration - Seek and value others’ perspectives and strive for diverse partnerships to enhance work toward common goals. Empowered Development - Play an active role in professional development as a business imperative. Minimum $169,222.00 - Maximum $253,000.00, plus incentive opportunity: The range shown represents a typical pay range or starting pay for individuals who are hired in the role to perform in the United States. Other elements may be used to determine actual pay such as the candidate’s job experience, specific skills, and comparison to internal incumbents currently in role. Typically, actual pay will be positioned within the established range, rather than at its minimum or maximum. This information is provided to applicants in accordance with states and local laws. Application Deadline: This will be posted for a minimum of 5 business days. Company benefits: Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits. Come discover more about Otsuka and our benefit offerings; https://www.otsuka-us.com/careers-join-otsuka. Disclaimer: This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position. It is not intended to include every job duty and responsibility specific to the position. Otsuka reserves the right to amend and change responsibilities to meet business and organizational needs as necessary. Otsuka is an equal opportunity employer. All qualified applicants are encouraged to apply and will be given consideration for employment without regard to race, color, sex, gender identity or gender expression, sexual orientation, age, disability, religion, national origin, veteran status, marital status, or any other legally protected characteristic.