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Revolution Medicines (RevMed) is committed to revolutionizing treatment for patients with RAS-addicted cancers, specializing in oncology drug discovery and development. With the mi
Senior Director, Clinical Pharmacology
Location
United States
Posted
22 days ago
Salary
$232K - $290K / year
Seniority
Lead
No structured requirement data.
Job Description
Senior Director, Clinical Pharmacology
Revolution Medicines
Role Description We are seeking a passionate and experienced Clinical Pharmacologist with strong early development background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. As a member of the Early Development Clinical Pharmacology group, you will: - Provide strategic insight and technical leadership within the Clinical Pharmacology function. - Author technical reports and/or regulatory documents for major milestones of clinical development, specifically IND, EOP1 & EOP2 Briefing Documents. - Participate in regulatory interactions and responses to regulatory questions. - Apply state-of-the-art quantitative modeling, including translational PK/PD, population PK, and exposure-response analyses, to guide recommended phase 2 dose/schedule (RP2Ds) selection for pivotal studies. - Work with the Discovery organization to support assets in the IND-enabling stage, including collaboration with DMPK and Toxicology groups in assessment of human start dose and assessment of the need for human DDI studies. - Work with the Clinical Development team in designing FIH study. - Design and report Clin Pharm studies such as hADME, Food-Effect and DDI studies. - Engage and work with CROs on clinical pharmacology activities. - Represent the Clinical Pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions. Qualifications - A Ph.D. or Pharm.D (with Fellowship) with Pharmaceutical Sciences background with 8-10 years of relevant industry experience in Clinical Pharmacology. - Prior experience with small molecules oncology drug development. - Familiar with FDA’s Project Optimus guidance. - Well-informed in current and emerging standards of regulatory requirements and expectations for clinical pharmacology. - Hands-on experience with WinNonlin and Clin Pharm study designs. - Strong understanding of DMPK, CMC and Toxicology and related regulatory guidance is required. - Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences. - A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment. - Prior management experience. Preferred Skills - Prior experience interacting with FDA on dose optimization. - Hand-on experience with PBPK models. Benefits - Competitive cash compensation. - Robust equity awards. - Strong benefits. - Significant learning and development opportunities. Base Pay Salary Range $232,000 — $290,000 USD
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Associate Clinical Director - Oncology
Private Health ManagementPrivate Health Management's team of clinical, research and care management experts provide unparalleled access to the best doctors, diagnostics and treatments to find the best of what’s possible in medicine. From routine and preventative care to serious or complex conditions, our integrated clinical approach and proprietary resources deliver more accurate diagnoses, optimal treatments and better outcomes that consistently improve, extend, and save lives. Our deep and trusted relationships allow us to gain access and expertly navigate the complex healthcare system on behalf of our clients. By maintaining independence from all providers and payors, we keep our members’ interests at the heart of every care decision. We serve as a committed healthcare champion working directly with individuals and families and with businesses that provide our services to their employees as a premium benefit
Role Description As an Associate Clinical Director at PHM, you’ll help patients in their deepest moment of need to challenge the status quo and go beyond the standard of care to achieve the best possible health outcomes. Working from your home office, you’ll serve as the lead clinician and engagement manager collaborating with team members through our process to uncover opportunities to improve your client’s care. Team members may include: - Additional clinicians - PhD scientists who mine the medical literature to identify data-supported care options - Care coordinators who manage care-related logistics You will utilize your clinical expertise and curiosity along with your tenacious problem-solving skills to: - Ascertain the key issues that must be addressed - Identify and engage with top experts - Guide patients to optimized care plans In collaboration with your personal care team colleagues, you will explore specialized diagnostics to better define the underlying mechanisms and array of treatment options beyond the current standard of care. Cutting through the barriers inherent to our chaotic healthcare system, you enable patients to access an unrivaled level of personalized care and attention while guiding them to the best possible treatment plan available. Qualifications - Active NP or PA license in your home state - A “Do what it takes to get the job done” attitude - Five years of clinical experience managing complex medical issues in an oncology and/or hematology environment - Exceptional client-facing skills including executive written & verbal communication - Impeccable attention to detail and organization - A highly professional demeanor under pressure - An insatiable clinical curiosity - Technically savvy and comfortable navigating various tech platforms - Significant bonus points for oncology experience mixed with another complex discipline Requirements - Offer high level clinical management and education to clients and families in a caring, compassionate manner - Work closely with clinical and research team members at PHM to identify latest therapies - Deliver comprehensive information on medical conditions, medications, treatments, and clinical trials - Articulate needs for collaboration with external care providers and interdisciplinary team resources - Network with key opinion leaders to invite collaboration and build relationships - Manage other clinical staff as it relates to a particular case or service line Benefits - Health/dental/vision benefits - Annual cash incentive program - 401k with match - Flexible PTO - Other benefits Compensation The target base salary for this position is $135,000-$140,000. This base salary is only a part of a total compensation package that may vary based on market forces, experience, location, and other relevant business considerations. Next steps Private Health Management is a remote company with employees around the United States. We’re committed to providing you with the best possible interview experience. If your application is selected for interviews, you’ll hear from a member of our recruiting team to schedule next steps. Interviews will include the hiring manager, peers, and often an executive from the department. Have a quick question about the role? Email careers@privatehealth.com or simply apply here.
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• Serve as the senior measurement and instrumentation strategist on assigned client accounts • Lead consulting conversations on attribution methodology and channel event instrumentation • Audit each client’s existing measurement stack and produce a written measurement assessment • Own end-to-end project management of analytics and measurement workstreams during new-client onboarding • Translate audit findings into a prioritized measurement plan • Act as the in-room expert during client measurement reviews and escalations
