Milestone Pharmaceuticals

Role Description Reporting to the Vice President of Marketing, the Director of Patient Marketing will be responsible for building and executing patient marketing strategies for CARDAMYST in the US market. The successful candidate will be a foundational member of the marketing leadership team and responsible for marketing to all external customers as well as leading patient CRM & Social Media agencies, commercial partner/vendor relationships, and leading cross functional collaboration. In addition, the Director of Patient Marketing will help to build and work closely with all key commercialization functions, including Corporate Communications/PR, Medical Affairs, Market Access, Commercial Operations, Regulatory Affairs, Finance, and Human Resources to ensure organizational alignment with the patient marketing strategy. Although primarily focused on activating persons with or suspected PSVT, the Director of Patient Marketing will also contribute to plans for future pipeline assets as well as life cycle activities for CARDAMYST. The successful candidate will ideally be willing to relocate to Charlotte but could also work remotely if they can commit to frequently commuting to attend key organizational and planning meetings with their peers. Location: 40% of work travel required Responsibilities - U.S. Patient Strategy & Launch Campaign Execution - Leading the development of U.S. patient and caregiver brand strategy for CARDAMYST, grounded in a deep understanding of the PSVT community, patient journey, and unmet needs. - Implementing effective patient marketing strategies across digital and community channels that are compliant, easily communicated, and clinically supported. - Building a robust operational and tactical execution plan directed at patients with PSVT across all touchpoints. - Developing and executing a multi-channel disease education program targeted at key external patient stakeholders. - Developing and executing an omnichannel patient directed product promotional plan, inclusive of DTP, to drive appropriate U.S. demand for CARDAMYST. - Patient Engagement & Community Leadership - Designing enhanced tactics for patient training on optimal use of CARDAMYST. - Designing and implementing tactics to drive persistence and ensuring achievement of forecasted refill rates. - Monitoring social media and insight mining to drive appropriate tactics for patient engagement. - Interacting in a professional manner with patient advocates for PSVT and/or HCP experts (doctors and nurses) to acquire insights and feedback on educational content through appropriate channels such as advisory boards and conferences. - Cross-Functional Leadership - Serve as a core member of the Marketing Team for CARDAMYST, partnering closely with Patient Services, Corporate Communications/PR, Medical Affairs, Market Access, Regulatory, Legal, and Compliance. - Ensure strong alignment between patient marketing initiatives and patient support programs, including development of branded patient materials. - Clearly communicate and champion patient brand strategy with internal stakeholders and external partners. - Support field teams with tools, training, and resources to enable effective and compliant patient engagement. - Collaborate closely with Commercial Data & Analytics to incorporate research insights into the development of key market development and branded promotional initiatives; adjust content as needed based on customer insights, and performance against internal KPIs. - Budget & Operational Excellence - Own agency-of-record relationships and drive excellence for patient marketing, including CRM and social media. - Lead the development of patient-facing materials to support consistent execution across channels. - Oversee promotional review (PRC) and ongoing optimization of patient tactics. - Manage patient marketing and patient support services marketing budget, demonstrating strong fiscal discipline and accountability. - Conduct regular performance reviews and field training refreshers to ensure awareness, education, and effective use of patient resources. Qualifications - Candidate must have at least 5 years of consumer/patient marketing experience in the pharmaceutical/biotech industry. - BA/BS degree. - Depth and breadth of experience in patient/consumer marketing with strong CRM expertise is required. - Social media/Omnichannel expertise. - Experience in planning, developing, executing, and quantifying ROI for multi-channel direct to patient campaigns. - Self-starter; able to drive multiple workstreams simultaneously and prioritize efforts to achieve objectives with minimal direction. - Strong analytical skills and ability to translate qualitative and quantitative insights into actionable strategies and/or tactics. - Ability to influence without direct authority and work effectively with cross-functional partners including but not limited to medical affairs, commercial, analytics, market access, legal and regulatory. - Experience in presenting and simplifying complex topics for senior management. - Can operate and thrive in a high paced and lean environment with minimal structure/processes. - Extensive experience developing and managing budgets and timelines. - Recent success in a US launch desired. - Experience in building markets (first to market). - Cardiology experience desired but not a must have. COVID-19 Vaccination Policy All Milestone employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered. EEOC Statement Milestone believes in a diverse environment and is committed to equal employment opportunities for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Milestone will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

WHY JOIN MILESTONE At Milestone, we aspire to advance and implement paradigm shifts for cardiac therapy. We are currently focused on developing anti‐arrhythmia treatments for self‐administration outside of the emergency department or hospital setting for patients with acute episodes of paroxysmal supraventricular tachycardia (PSVT) and atrial fibrillation (AFib), as well as other episodic cardiovascular conditions. In addition to our science and innovation, we are a team guided and driven by our core values. Patient needs and empowerments are continually upheld as central to our mission. Our teamwork is strengthened in an environment in which we support and challenge each other while enjoying and celebrating our achievements. We maintain an entrepreneurial, proactive, and action‐oriented mindset that places high value on grit, courage, and resolve. Decision‐making is based on evaluating information and an idea’s merits; data‐driven proposals are both supported and sought. We act individually and as a team with humility, candor, empathy, and unwavering integrity. We have been successful in attracting and empowering best‐in‐class talent, and we seek those with passion to join on our journey to develop treatments and to motivate change. We are excited about the possibilities of this team and what we can accomplish together. SUMMARY - Milestone Pharmaceuticals is seeking a Director / Senior Director of Revenue & Government Pricing to lead the end-to-end revenue function, including gross-to-net (GTN), government pricing, and strategic revenue analytics. This role is a critical leadership position responsible for ensuring accurate financial reporting while serving as a strategic partner to Commercial, Market Access, and Executive Leadership. The ideal candidate will bring deep expertise in pharmaceutical revenue management, including GTN modeling, government pricing (AMP, Best Price, etc.), and commercial contracting. This individual will own the design, execution, and continuous improvement of revenue processes, systems, and analytics, and will play a key role in supporting product launch readiness and long-term growth strategy. - The Director will lead an effort to understand and analyzing gross to net estimates and related liabilities, thereby supporting strategic forecasting and budgeting efforts. This hybrid role requires building relationships with key business partners in the Sales, Contracting, Marketing and Finance organizations, as well external vendors. Developing and implementing industry best practices within the Revenue Reporting and Accounting space. Finally, this position will be responsible for leading the annual and quarterly financial reporting process according to U.S. GAAP. DUTIES AND RESPONSIBILITIES Key Responsibilities 1. Revenue Accounting & Gross-to-Net Leadership - Own the end-to-end GTN process, including accruals, estimates, true-ups, and financial close - Ensure compliance with ASC 606 and U.S. GAAP for all revenue recognition activities - Oversee preparation and review of monthly, quarterly, and annual revenue reporting - Lead account reconciliations, variance analysis, and audit support - Maintain a robust control environment to ensure accuracy and compliance 2. Government Pricing & Compliance - Own all government pricing calculations, including AMP, Best Price, Non-FAMP, and related metrics - Oversee Medicaid, Medicare, Tricare, and other federal/state program rebates and reporting - Ensure compliance with all regulatory requirements, including Public Law filings and pricing transparency laws - Partner with Compliance and Legal to manage pricing risk and regulatory exposure 3. Forecasting, Modeling & Analytics - Lead development of GTN forecasting models, including payer mix, channel dynamics, and demand drivers - Develop and maintain driver-based revenue models to support budgeting and long-range planning - Provide scenario analysis and decision support to leadership on pricing and contracting strategies - Deliver actionable insights on revenue trends, risks, and opportunities 4. Commercial & Market Access Partnership - Serve as a strategic finance partner to Market Access, Commercial, and Pricing teams - Evaluate financial impact of commercial contracts, rebates, and pricing strategies - Support contract negotiations through ROI modeling and profitability analysis - Participate in Contract Pricing Committee and provide data-driven recommendations 5. Trade, Distribution & 3PL Oversight - Oversee revenue-related activities of third-party logistics (3PL) providers - Monitor channel inventory, wholesaler activity, chargebacks, and returns - Ensure accuracy of data flows from wholesalers, PBMs, and other external partners 6. Systems, Data & Process Optimization - Own revenue systems and data infrastructure (e.g., GTN modeling tools, contract systems) - Drive automation and scalability of revenue processes - Ensure data integrity across multiple data sources (3PL, PBM, government, etc.) - Implement best-in-class tools and processes to support growth 7. Financial Reporting & SEC Filings - Lead preparation of revenue disclosures for SEC filings (10-K, 10-Q, MD&A) - Collaborate with Finance leadership on external reporting requirements - Support internal and external audit processes 8. Team Leadership & Cross-Functional Collaboration - Build, lead, and develop a high-performing revenue and government pricing team - Manage internal staff and external vendors/consultants - Foster strong cross-functional relationships across Finance, Commercial, Market Access, Compliance, and Legal 9. Product Launch & Business Strategy Support - Support new product launches with GTN model design and pricing strategy - Partner with Business Development and Commercial teams on revenue implications of new opportunities - Ensure scalable processes are in place for future product commercialization EDUCATION, KNOWLEDGE AND SKILLS - Degree in accounting or finance with a CPA required - A bachelor’s degree in finance or accounting and at least 10 years of broad scope accounting, reporting and analysis experience from the pharmaceutical/biotechnology space - Deep expertise in gross-to-net accounting, commercial contracting, and government pricing regulations - Proven experience supporting product launches and commercial organizations - Experience interacting with executive leadership and influencing strategic decisions - Strategic thinker with strong analytical and problem-solving skills - Excellent communication and executive presentation skills - Ability to operate in a fast-paced, growth-oriented environment - Strong attention to detail with a commitment to accuracy and integrity - Advanced Excel, Microsoft Dynamics and data analysis skills - Confidence, strong communication skills and the ability to present to senior business leader - Ability to adhere to processes and controls to satisfy routine internal/ external audits - CPA or MBA highly preferred - The preferred location for this role is our Charlotte office; however, remote work may be considered for qualified candidates. LOCATION The preferred location for this role is our Charlotte office; however, remote work may be considered for qualified candidates. COVID-19 VACCINATION POLICY: All Milestone employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered. EEOC STATEMENT: Milestone believes in a diverse environment and is committed to equal employment opportunities for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Milestone will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

About Milestone Pharmaceuticals Milestone Pharmaceuticals Inc. (Nasdaq: MIST) is a biopharmaceutical company focused on the development and commercialization of innovative cardiovascular medicines. Cardamyst™ (etripamil nasal spray) is the company’s first commercial product — a first-in-class, self-administered treatment for paroxysmal supraventricular tachycardia (PSVT) in adults, approved by the FDA in December 2025 and launched through retail pharmacies in Q1 2026. Position Overview The Director, Market Access is a hands-on operational leadership role responsible for executing market access functions supporting the Cardamyst commercial launch and ongoing lifecycle management. This person will serve as the primary point of contact for all market access vendors and will manage the day-to-day execution of payer contracting support, GTN/accruals analytics, pull-through materials, patient support programs, government pricing operations and state compliance reporting. The ideal candidate is someone who thrives in a small-company environment and will be involved in every aspect of market access — from reviewing government price calculations to troubleshooting a patient’s copay issue to preparing a formulary negotiation model. The role requires a willingness and ability to operate at both the strategic and tactical level. Essential Duties and Responsibilities Patient Support Program Operations - Serve as the primary vendor relationship owner for all patient support partners including copay card (UBC), eVoucher/denial conversion (CoverMyMeds, Relay Health), prior authorization support (CoverMyMeds PA+), patient support call center, and any future programs - Monitor and optimize patient journey metrics across dispensing options: PA submission through approval, pharmacy adjudication, copay program utilization, fill rates, and abandonment - Proactively identify and troubleshoot access barriers throughout the patient journey; develop action plans to address issues surfaced through data, vendor feedback, or field intelligence - Manage program compliance, including copay card accumulators/maximizers, cash-pay restrictions, and coordination of benefits between programs - Lead patient support reporting and analytics, including copay card capture rates, average buydown amounts, out-of-pocket costs, eVoucher utilization, and denial conversion rates Government Pricing and Compliance - Manage government pricing operations through regular standing meetings with the contracted government pricing vendor (CGPV), ensuring timely and accurate calculation submissions and resolving any open items - Execute initial review and approval of government price calculations on a recurring basis; provide initial review of quarterly and monthly submissions prepared by the CGPV - Maintain Medicaid state portal registrations, federal contract registrations, and ensure ongoing compliance with federal and state pricing programs (Medicaid Drug Rebate Program, 340B, TRICARE, VA/FSS) - Own state price transparency report generation, registration maintenance, and submission tracking across all applicable states - Support government pricing audits, information requests, and legislative/regulatory change impact assessments as they arise - Serve as operational liaison to Finance for rebate invoice approvals, payment coordination, and reconciliation of contracted terms against actual payments Payer Contracting and Formulary Access - Support GPO and PBM contract negotiations by preparing financial models, scenario analyses, and recommendation decks for Pricing Committee review - Maintain and update the formulary coverage tracker across commercial, Medicare Part D, and Medicaid channels using claims data and Fingertip/Clarivate DRG sources - Track contract performance against negotiated terms; flag variances and coordinate with Finance and external partners to resolve discrepancies - Support payer bid submissions, rebate rate negotiations, and contract amendment processes across GPOs (Ascent, EMISAR, Zinc) and direct payer arrangements - Prepare payer engagement materials including coverage status updates, value proposition summaries, and formulary decision support content GTN / Accruals and Analytics - Support GTN forecasting and accrual processes by maintaining data inputs, running scenario models, and reconciling forecast-to-actual variances - Produce and distribute regular market access reporting: TRx trends, 867 sell-through, payer mix, rebate accruals, and copay program economics - Closely collaborate with Finance to ensure GTN models reflect current contract terms, payer mix shifts, and patient program utilization trends - Build and maintain ad hoc analyses as needed to support executive decision-making, board reporting, and commercial forecasting Pull-Through and Field Access Support - Support the development of, and maintain payer-facing and field-facing materials including coverage status tools, representative leave-behinds, reimbursement guides, and access messaging - Coordinate with Marketing, Medical, Regulatory, and Legal on promotional review committee (PRC) submissions for all market access materials - Build and communicate formulary coverage updates to field teams to support pull-through efforts and prescriber education on access pathways - Support the development and execution of payer advisory boards, market research, and field access training content Cross-Functional Collaboration - Partner with Commercial Operations, Sales, and Marketing to align market access initiatives with broader commercial strategy - Collaborate with Medical Affairs on evidence generation priorities and HEOR data needs for payer engagements - Support distribution and trade operations as needed, including coordination with retail pharmacy and wholesale distribution partners - Contribute to forecast adjustments and launch planning discussions with a market access perspective on demand drivers and barriers Required Qualifications - Bachelor’s degree required; MBA or advanced degree preferred - 8+ years of pharmaceutical industry experience with progressive responsibility in market access, pricing, contracting, or patient services - Direct experience in at least three of the following: payer/PBM contracting, government pricing operations, patient support/hub program management, GTN/accruals, or formulary access strategy - Demonstrated experience managing external vendors and holding partners accountable to deliverables, timelines, and quality standards - Working knowledge of government pricing programs (Medicaid rebate, 340B, TRICARE/VA, Medicare Part D) and state price transparency requirements - Proficiency in Excel-based financial modeling, scenario analysis, and data-driven decision making - Experience in a small-company or launch environment where individuals are expected to operate across functional boundaries - Strong written and verbal communication skills with the ability to synthesize complex information into clear, actionable deliverables for senior leadership Preferred Qualifications - Experience supporting a retail pharmacy-distributed product - Familiarity with copay card program design and economics, eVoucher platforms, and denial conversion programs - Prior experience supporting a product launch where payer education and formulary access required proactive market shaping - Knowledge of cardiovascular, CNS, or acute/episodic therapeutic areas - Experience with data sources including IQVIA, Clarivate/DRG Fingertip, CoverMyMeds, and claims-level analytics - Comfort working directly with Finance on accrual methodologies, balance sheet impacts, and audit-ready documentation Location This is a remote position. Periodic travel may be required for payer meetings, vendor summits, and industry conferences. COVID-19 VACCINATION POLICY: All Milestone employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered. EEOC STATEMENT: Milestone believes in a diverse environment and is committed to equal employment opportunities for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Milestone will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description Reporting to the Senior Director of Commercial Strategy and Execution, the TLL function will be responsible for building relationships with speakers and regional thought leaders as well as executing marketing strategies for the launch of CARDAMYST in the US market. The Thought Leader Liaison (TLL) role is a field-based position within the US commercial marketing organization that will focus on commercials key option leader (KOL) relationship engagement, promotional speaker training and supporting the strategic execution of commercial insight generation to inform company direction. The position will have a strong dotted line to the VP of Marketing. The TLL function will be primarily focused on the launch of CARDAMYST for the PSVT indication and will be bound by promotional guidelines using PRC approved promotional materials. The successful candidate will ideally work remotely, but frequently travel to meet with HCPs, attend national and regional medical conferences and interface with key Milestone stakeholders in the home office in Charlotte as needed. Responsibilities - Speakers Bureau Management & Speaker Engagement - Identification and recruitment of KOLs to deliver high-quality speaker programs on disease state and product, when appropriate - Managing relationships of contracted commercial speakers and consultants - Training speakers using approved speaker materials (annual speaker training and, when needed, field-based training) - Execution of speaker programs in accordance with compliance policies - Assessment of speaker performance at live and virtual programs - Medical Conferences - Contribute to the development of national and regional commercial conference strategy and associated commercial tactics to amplify HCP awareness - Execution of peer-to-peer promotional efforts at medical conferences (e.g., product theaters) - Marketing Insights & Strategy - Establish Milestone as a credible and trusted partner amongst speakers and regional thought leaders - Engage with assigned KOLs and solicit feedback, as necessary - Support disease state or on-label product conversations focused on key topics - Execute KOL engagement activities in the field and at key congresses - Co-Lead Peer-Peer Education Steering Committee - Educational Programming Support - Provides input and support in developing account plans for Sales - Support sales team with Regional Programming eg: PCNA Regional Meetings - Provides field-based speaker program training for Sales on how to efficiently implement programs - Support the execution of approved consulting opportunities - Assist in the identification of Healthcare Professional (HCP) commercial consultants - Facilitate, participate in, and attend advisory boards, where appropriate Qualifications - Minimum 10 years’ experience in marketing/sales leadership - Minimum 5 years’ experience in Cardiology Preferred - Launch experience strongly preferred - Experience with speaker’s bureau required, including building content and training speakers - Proven ability to manage large geographical territory, ability for extensive business travel, at least 70% - Demonstrated ability to build productive stakeholder relationships and effectively meet their needs - Ability to inform strategies, develop tactics, and execute against strategic plans - Strong business acumen - understands market dynamics, business drivers, corporate goals, and impact on strategy - Effective verbal and written communication skills and organizational abilities - Self-driven with strong organizational and planning skills - Ability to leverage appropriate interpersonal styles and techniques to gain acceptance of ideas or plans - Highly collaborative with the ability to manage multiple projects simultaneously - Embody a can-do entrepreneurial mindset with a willingness to both lead and support key company initiatives - Conduct all aspects of business in compliance with Milestone values, policies, SOPs, and the laws, regulations, and codes that apply to our business performance. COVID-19 Vaccination Policy All Milestone employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered. EEOC Statement Milestone believes in a diverse environment and is committed to equal employment opportunities for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Milestone will make reasonable accommodation for qualified individuals with known disabilities in accordance with applicable law.