Eupraxia Pharmaceuticals Inc.

Job Code: HR-PD 1001 Job title: Chief Medical Officer Reporting to: CEO ____________________________________________________________________________ Scope As the top medical executive in the corporation responsible for overseeing the development of the company’s global product portfolio strategy to bring products, services and programs to market in compliance with global regulatory, legislative and medical/health requirements. The position typically has functional responsibility for all clinical development activities, which runs from Phase I through Phase IV programs and will have responsibility for on-market products. Responsible for developing strategic plans for the company’s products to meet quality and safety standards required by medical and regulatory agencies. This role has responsibility for all clinical development, including providing leadership to medical affairs, safety, biometrics and data management to ensure a successful product approval and launch. This role will work closely with the Chief Development Officer to ensure the portfolio management activities for the company to ensure appropriate objectives and resources are deployed to meet strategic portfolio plans delivering on key milestones to advance all of the company’s products in development. Responsible for representing the company with legislative agencies globally addressing the scientific and medical/health aspects of the company’s product portfolio. The position may also provide consultative guidance on health-related matters to leaders across the company and with outside health/medical and regulatory organizations. They will oversee the company’s product portfolio investments to meet fiscal year goals, providing strategic input to the annual and long-range budgetary process. This role combines both aspects of being a physician and an executive, focused on utilizing best practices and an evidence-based approach across all medical aspects of Eupraxia’s business. ____________________________________________________________________________ Key responsibilities and duties: - Reports directly to the Chief Executive Officer and is a key member of the Executive Team. - Is the company’s principal medical adviser and the professional head of all medical staff. - Provides clinical insight and strategic direction for the company - Represents the voice of all clinical stakeholders (such as patients, patient advocacy groups, partner organizations, physicians within and outside the company). - Provide managerial oversight of all clinical development activities, including clinical science, clinical operations and safety reporting/pharmacovigilance - Provide oversite into all medical affairs activities including: - Ensuring Eupraxia features prominently at scientific congresses and scientific publications - Overseeing the conduct of Investigator Initiated Trials - Provide clinical input into the evaluation of new products, technologies and companies for potential alliances, partnerships and acquisitions to expand the breadth of the company’s business - Provide a strong clinical tone/perspective to our regulatory relationships as well as partners. - Interact with the investment community in an effort to gain additional financing, including presenting medical information to potential partners and investors - Work with the clinical team to ensure appropriate input into strategy, its focus and prioritization. - Interface with internal clinical and business development teams, and with external academic and governmental scientists and clinicians - Monitor changes in the medical environment, which may impact the global drug development process and other aspects of Eupraxia’s business - Provide clinical expertise and input to research & development, business development and commercial efforts. - Ensure corporate adherence to ethical and good clinical practices (GCP). - They will ensure compliance with all financial signatory, clinical, regulatory and ethical expectations and regulations. - Adherent to financial controls as communicated by the finance function on behalf of the company. - They will ensure compliance with all Corporate Policies, rules, and regulations as set out and communicated by the company pursuant to good business practice. ____________________________________________________________________________ Education, qualifications and work experience: - Qualified Physician with a strong insight into research - Board Certification and significant prior clinical experience. - Physician with 10+ years of direct experience in Clinical Development, Medical Affairs and Safety in positions of increasing responsibility in a biotech or pharmaceutical environment. - Extensive experience ranging from Phase 1 clinical development through NDA, encompassing multiple phases of clinical development and managing complex clinical trials. - Ability to direct an extensive network of medical experts and appropriate clinical sites worldwide to successfully complete clinical development of a drug. - A track record of success in efficiently executing complex clinical trials that are designed to demonstrate a clear competitive advantage over existing therapies, while compressing timelines. - Extensive experience in dealing with the FDA/EMEA on all aspects of clinical development, including having filed both INDs and NDAs. - An in-depth exposure to one of Rheumatology, Inflammatory Diseases is preferred, as is concentration on small molecules. Experience in a broad range of disease areas, including oncology, an advantage. - Senior level negotiation experience in working with CROs, and / or co-development partners. - Proven ability to work successfully across functions in a matrix management approach - Broad knowledge of the drug development process, clinical development planning, clinical research methodologies and execution, regulatory requirements; some knowledge of biostatistics and epidemiology - Knowledge of general pharmaceutical science in its application to clinical development programs - Proven track record in delivering global clinical research programs to budget and timeline specifications - Successful experience in coordinating internal and external resources for clinical development, and in working with pharmaceutical partners - Direct hands-on experience in managing high-quality successful clinical trials and clinical trial project teams - Credibility, influence and respect within the pharmaceutical industry - Experience with orphan drugs and rare diseases a plus - Demonstrated qualities of executive leadership: ability to interact productively and effectively influence other senior management and external colleagues; ability to set and communicate goals, and to drive efforts, overcome obstacles and achieve results within budget and timeline specifications; exceptional leadership, organizational, interpersonal and communication abilities; team-building and team-oriented approach; willing to contribute at all levels; highly developed negotiation skills; high ethical standards and integrity; independent thinking; excellent judgment in making information and logic-based decisions - Excellent verbal, written and interpersonal communication skills. - Is able and willing to travel internationally, especially between Canada, US and Europe Location Seattle, Washington (Remote) Department Clinical Employment Type Full-Time Minimum Experience Executive

Scope: The Senior Vice President Operations has a dual function. The job holder will provide matrixed leadership across the Research and Development teams and is responsible for facilitating Eupraxia’s cross-disciplinary teams to effectively strategize, plan, and execute on Eupraxia’s programs from development candidate selection through clinical development, regulatory submission & approval, through to preparation for commercial launch. This role ensures Eupraxia’s executes on its important priorities in an aligned, integrated manner across all functions to support company goals and accelerate the development, evolution and commercialization of the product portfolio. This role is also functionally responsible for overseeing the delivery of the company’s clinical research activity involving all clinical trials execution, the documentation of product trials, analysis and reporting to prepare documentation required for including in the company’s regulatory and legislative product approvals. The job holder has oversight for the development of clinical protocols to support the company’s product strategy, working with colleagues to ensure appropriate data collection and management and the development of final reports in compliance with appropriate standard operating procedures, regulatory and medical standards. The role also has the responsibility to oversee the development and delivery of medical Affairs activities in support of our development candidates. This position interacts with various groups within the company and external to the business to oversee clinical research activities. Responsibilities: Clinical • Oversees the planning, management and reporting of clinical studies through oversight of cross-functional study activities, proactive issue resolution and communications of study timelines and deliverables. • Identifies and manages suitably qualified internal personnel and external vendors to achieve clinical milestones and quality standards. • Organises and manages interactions with external therapeutic area experts to advise on and support implementation of clinical development plans. • Gains alignment with various internal partners and stakeholders on clinical goals and resource needs. Includes working with core project teams to establish appropriate budgets and other resource plans. • Ensures that studies are conducted in accordance with SOPs, GCP and regulatory guidelines. • Coordinating author for: o Clinical trial protocols / strategy o Investigator Brochure o Clinical study report o Annual safety report o Publications • Interacts with Regulatory and other partners/stakeholders in the completion and submission) of Regulatory applications and filings. • Participates in FDA or other health authority interactions as needed. • Other ad hoc duties and assignments as requested for the overall performance of the function and the company. Responsibilities: Operations • Works with executive management to implement and deliver the organizations R&D strategy and annual objectives. • Develops actional business strategies, objectives and plans that ensure alignment with short- and long-term corporate objectives. • Strategically oversees employees from different departments and locations to ensure efficient and successful development/execution of Eupraxia’s portfolio of drug candidates across all stages of development, including lifecycle management. • Supports product-related decisions at key transitions and decision stage-gates • Directly manages program management, and Clinical Operations. • Works in partnership with other functions (e.g., manufacturing, nonclinical, clinical, marketing, Business Development, etc) to deliver successful development of Eupraxia’s portfolio of products. • Provides strategic input and guidance on development plans, ensures on-going alignment to project teams’ objectives and the overall execution of deliverables. • Acts as sounding board to manage issue resolution and facilitate team’s evaluation and development of recommended strategic plans. • With an oversight of the overall portfolio and drug candidate timelines, ensures efficient and timely communication between/across functions and senior management on issues, interdependencies, including budget and resource constraints and assists with addressing program risks and challenges to advance programs. • Prepares topic and issue-specific briefs for executive management and Eupraxia Board of Directors • Assists with identifying, implementing, and communicating across projects the best practices related to the development, initiation, planning, execution, control and closing of nonclinical, clinical studies, and/or studies to support post-approval requirements. • Evaluates, implements, and enhances management’s best practices and governance operating model to strengthen teams, tools, and communication channels. • Provides guidance and oversight to management on the development, implementation and refinement of project management tools and reporting. • Provides objective oversight of R&D topics for discussion and escalation to the executive team. • Active participant in due diligence, alliance management and communications/disclosure activities and strategy. • Critically reviews strategic contracts (e.g., partnering and acquisitions) with an eye to alignment with Eupraxia operations. • Builds and maintains relationships with professionals and organizations in the Pharma/Bioscience industry. • Manages, coaches, and mentors’ both direct reports and others across the business. Requirements: • Minimum of 20 years’ experience with progressive responsibility in drug development or pharmaceutical research and development (R&D), including a minimum of 10 years’ experience in a program management role in a pharmaceutical, biotechnology, or related environment. Experience in small molecule and rare disease drug development preferred. • In-depth understanding of the drug development process, including hands-on experience managing cross-functional development teams across all stages of development (pre-IND, clinical development, global regulatory filings, approvals, and post-marketing). • Ability to motivate, organize and respond to employees of many different areas of expertise • Excellent analytical and planning skills • Strong organizational, time-management and program management skills • Excellent verbal and written communication and skills including presentation skills • Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members. • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines. • Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects. • Ability to interact effectively at all levels and across different cultures. • Skilled in managing employees and external partners in a team environment. • Excellent business and budget-planning skills • Demonstrated skills in negotiation and facilitation. • Knowledge of change management. • Excellent verbal, written and executive presentation skills. Additional attributes: • Ability to maintain a high level of confidentiality. • Exercise excellent customer service skills. • Excellent communication and time management skills and possess a high level of organizational ability. • Attention to detail due to various factors affecting contract entitlements. • Possess troubleshooting, problem solving, and creative/innovative thought processing skills. • Understand office formats and procedures. • Demonstrated leadership skills and ability to document and implement processes and procedures. • Self motivated and self-directed Location Seattle, Washington (Remote) Department Clinical Employment Type Full-Time Minimum Experience Senior Manager/Supervisor