Alexion Pharmaceuticals

Title: OneSource Support Specialist (EST) Location: US Job Description: locations US time type Full time job requisition id R-252738 This is a fully remote role based in the United States. Ideal candidate will reside within the time zone of the support territory, though all qualified candidates will be considered. The hours for this role would be 8:30AM - 5PM EST. Role may require up to 10% travel to existing Alexion sites. Travel needs may be higher during new hire trainings and refresher trainings. This is what you will do: The OneSource Support Specialist is a high-touch Patient Support Program (PSP) role within the Patient Services Department centered on delivering exceptional and personalized support to patients within the Alexion Rare Disease patient journey. Working as part of a Regional Care Team, the OneSource Support Specialist serves as the primary point of contact to patients and caregivers throughout their treatment journey from initial onboarding of product through long-term customized treatment adherence support. OneSource Support Specialist provide disease state education, treatment support through community connections, and access support for patients with rare and ultra-rare diseases. OneSource Support Specialist ensure patient treatment compliance and provide resolutions to non-clinical treatment issues for patients through communication and collaboration with both internal cross-functional partners and external stakeholders. You will be responsible for: • Providing exceptional initial onboarding experience and long term adherence support • Share materials on the disease, diagnosis, community resources and treatment support • Maintain and communicate up-to-date knowledge of the resources available as needed, including approved external resources • Place the required welcome calls to patients to introduce the OneSource program and confirm required/requested support • Communicate Benefit Investigation (BI) results with patients and HCP and help interpret them, as needed • Inform patient of financial support eligibility based on available programs • Enroll patient in Alexion financial assistance programs as eligible or refer to external support programs as appropriate • Proactively conduct routine and/or year-end reverification of coverage outreach by working with patients and caregivers, healthcare providers, insurance companies, and Alexion colleagues • Connect patients to the Alexion patient community and inform them about available advocacy groups for their disease • Assist patients in receiving required vaccinations either through Alexion or other vaccination locations • Efficiently navigate CRM documentation and other required record keeping during all patient interactions as to maintain high visibility into patient case status • Properly and immediately report Adverse Events during any customer interactions in the PV Event Reporting Tool • Act as the primary coordinator of all HCP needs across onboarding from case creation to product delivery and ongoing support through lifetime of product use • Coordinate with other appropriate HCP facing roles and cross functional partners to respond to questions from physicians and office staff and address any issues • Communicate with HCPs to confirm required/requested support or obtain missing information • Proactively and effectively consult with and engage the appropriate internal cross functional partners to resolve barriers quickly • Maintain working understanding of the reimbursement process, and leverage knowledge to communicate with internal and external stakeholders while insurance approval is being obtained and work with appropriate field specialists for denial/appeal support • Trigger initiation of adherence program on conclusion of onboarding and connect with patients through defined channels for the determined touchpoints based on product-specific programs • Educate prescribed patients and their caregivers regarding how to prepare for and what to expect during the long-term adherence of the Alexion product or switching from one Alexion product to another • Provide emotional support for patients and caregivers on continued administration of Alexion products Will also be crucial to: • Develop compliant and collaborative professional relationships with all relevant internal and external customers including but not limited to Patient Education Managers, Field Reimbursement Managers, Regional Account Managers, Customer Operations Representatives, Medical Accounts, Access Specialists, Specialty Pharmacies, Site of Care staff, and office coordinators • Effectively escalate access issues by informing the right stakeholders of actions to be taken to resolve any pending items in a timely manner • Collaboratively work with and share responsibilities with other Alexion members and external partners members for pull through of the target patient and HCP experience • Participate in any role appropriate cross functional collaboration work (e.g.Hypercare calls, regional cross functional meetings, One Alexion meetings) • Participate in other project work as needed You will need to have: • Associates Degree is required • Minimum of 3 to 5 years Case Management OR recognized equivalent of education and experience (e.g. contact center, nursing, social service support, healthcare customer service, insurance reimbursement, patient advocacy, etc.) • Well-developed, effective communication, collaboration and problem-solving skills, as well as data entry/computer literacy skills • Ability to work independently, be goal-directed and have strong organizational skills • Must be flexible as well as easily adapt to a changing work environment which will require ongoing maintenance/training of job-related skills/activities • Must be willing to adjust work schedules in response to department needs. • The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, email, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. We would prefer for you to have: • BA/BS Degree is preferred; patient contact center or patient support program experience is a plus • Excellence at communicating over the phone and handling phone systems and/or experience in a call recorded environment • Familiarity with the relevant legal and regulatory components of the pharmaceutical and biotech industry • Rare disease experience a plus • Deep understanding of insurance coverage and reimbursement processes • Familiarity with managed care and particularly “buy and bill” therapy as well as with reimbursement for infused therapies • Experience dedicated to assisting patients/caregivers • Demonstrated success working within high performing cross-functional teams • Strong empathetic, communication and listening skills • Ability to act with urgency, flexibility, and creativity to quickly get patients on therapy • Strong organizational skills and ability to adapt to change and react constructively in a high-energy and fast paced environment • Demonstrates initiative, teamwork, and accountability The annual base salary for this position ranges from $86,663 -$129,950. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Title: Case Manager, Rare Endocrinology and Rare Tumors (EST) Location: US - Cincinnati - OH Job Description: Remote position supporting Easter Standard Time Zone (8:30am EST – 5pm EST) with occasional patient meeting and HCP office support, up to 6x/year, outside those hours of operation. Up to 15% potential travel to existing Alexion sites and off-site meetings, patient and HCP engagements by request and when appropriate. Start date as soon as possible. This is what you will do: This position is a high-touch Patient Services role centered on delivering personalized support to patients within the Alexion Rare Disease patient journey. The Case Manager (CM) serves as the primary point of contact to patients and caregivers throughout their treatment journey from onboarding, interim treatment coordination, and long-term customized treatment adherence support. CMs provide disease state education, treatment support, and access for patients with rare and ultra-rare diseases. CMs ensure patient treatment compliance and provide resolutions to treatment issues for patients through communication and collaboration with both internal and external stakeholder partners. You will be responsible for: Patient Support & Navigation (70%) - Patient’s Initial and Long-term Support: Provide initial and ongoing patient interactions to address questions and integrate therapy into their daily lives - Act as the primary point of contact for case management and onboarding activities specific to the patient - Place Welcome Calls: After case creation in the CRM, place the required welcome calls to patient (and HCP in coordination with SP vendor) and introduce the program or confirm required support respectively - Share Disease, Product & Program Education Materials: Share materials on disease, diagnosis, and treatment support with patients - Introduce Patient Community: During the first touchpoint, Connect the patient to the ALXN patient community and inform them about available advocacy groups for the indication - Communicate Benefits Investigation Results: On receiving the BI results from the SP vendor, contact the patient and share results - Coordinate Injection Training Support: Assist patients in receiving In-home or virtual injection training assistance during first injection and coordinate follow up service as needed for second round of injection training (also offer infusion support) - Conduct Adherence Program Touchpoints: Trigger initiation of adherence program on conclusion of onboarding and connect with patients through defined channels for the determined touchpoints based on product specific programs - Execute Mentorship Program: Engage appropriate patients to become mentors if desired to new patients starting therapy and enable them to connect - Support Patients who Restart on Treatment: Reconnect with patients who have lapsed and decided to restart on treatment, offer support services - Conduct Annual BI Communications with patients - Practice vigilant documentation and record keeping during all patient interactions as to maintain high visibility into patient case status and ease resolution processes, when needed - Properly and immediately report Adverse Events during any customer interactions in the PV Event Reporting Tool Internal Cross-Functional Collaboration (15%) - Develop compliant and collaborative professional relationships with all relevant internal and external customers including but not limited to Field Reimbursement Managers, Regional Account Managers, Customer Operations Representatives, medical accounts, Funding Specialists, Access Specialists, Specialty Pharmacies, site of care staff, and office coordinators. - Effectively escalate access issues by informing the right stakeholders of actions to be taken to resolve any pending items in a timely manner - Collaboratively work with and share responsibilities with other Alexion members and external partners members for pull through of the target patient and HCP experience External Vendor Engagement and Collaboration (15%) - Develop compliant and collaborative professional relationships will all relevant external vendor partners including but not limited to PantheRx SP Enhanced Services partners, Ashfield In-Home Injection Trainers, Product Storage Service vendors, Sharps Disposal service vendors, and Copay and BI support vendors - Effectively escalate vendor service provider issues which may impact patients by informing appropriate internal stakeholders and taking needed actions to resolve issues in a timely manner - Collaboratively work with and share responsibilities with external vendor partners to optimize and create a delightful patient and HCP experience You will need to have: - Associates Degree, at minimum, is required; a counseling, social work, nursing, advocacy, or science background and/or advanced degree is a plus - Minimum of 3 to 5 years Case Management OR recognized equivalent of education and experience (e.g. case management, nursing, social service support, insurance reimbursement, patient advocacy, etc.) - Working knowledge of insurance coverage and reimbursement processes - Familiarity with the relevant legal and regulatory components of the pharmaceutical and biotech industry - Well-developed, effective communication and problem-solving skills, as well as data entry/computer literacy skills - The duties of this role are generally conducted in a home office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. We would prefer for you to have: - Rare disease experience a plus - Deep understanding of insurance coverage and reimbursement processes - Familiarity with managed care and particularly “buy and bill” and pharmacy benefit therapies as well as with reimbursement for infused and injectable therapies - Ability to coordinate with cross-functional teams for pull-through of patient care - Experience dedicated to assisting patients/caregivers - Demonstrated success working within cross-functional teams - Strong empathetic, communication and listening skills - Ability to act with urgency, flexibility, and creativity to quickly get patients on therapy - Strong organizational skills and ability to adapt to change and react constructively in a high-energy and fast paced environment - Demonstrates initiative, teamwork, and accountability

Title: Senior Medical Director Clinical Development Neurology Location: US - Boston - MA Hybrid Full time Job Description: Senior Medical Director, Clinical Development Neurology We are looking for a Neurology medical expert who will be responsible for the clinical development of neurology assets. This position offers substantial opportunities to work with cross-functional project teams.. This role is usually assigned to 2 or more programs, , serving on strategic teams (e.g., disease strategy team) and providing input to strategic decisions at the TA level. This is a therapeutic area role and is specifically designated to provide medical leadership and input to Program Teams across drug development (i.e., transitioning molecule through IND/CTA and First in Human study stage to Proof of Concept /Phase2 stage, Phase 3 and regulatory approval ). You will be responsible for: - Serve as subject medical expert and clinical development leader accountable for 2 (or more) programs, including but not limited to the preparation and execution of a clinical development strategy and related documents including protocols, charters, statistical summary reports, meeting presentations, publications, and clinical sections of regulatory documents. - Provide clinical development leadership for protocol execution including interaction with investigators, and contributing to data review, data analysis and the preparation of final clinical study reports. - Provided strategic medical guidance to phase I/II/III development programs and oversight of global patient clinical trials/trial team (s) in conjunction with Clinical Operations on assigned program(s) - Provide medical monitoring for assigned programs and assessment of safety events in conjunction with Safety teams - Represent clinical team on the cross-functional program team accountable for medical input to integrated development plan - Development of medical content for regulatory document, and responses (including but not limited to pre-IND, IND briefing packages and common technical documents) - Lead identification and external engagement with key opinion leaders for assigned programs including at advisory meetings, investigator meetings and patient advocacy organizations - Fostering development of Medical Directors in the - Providing scientific and medical input (consultative services) to other R&D, commercial, translational, medicine and business development functions and leads or oversees clinical activities to support due diligences - Working internally with other members of the CDP to drive program strategy and CDPs - Coordinate communications and planning bet medical functions (Global Medical Affairs, Safety, Clinical Operations, Biostatistics, Epidemiology and Medical Science) as it relates to clinical development study design, execution and interpretation of results. - Driving awareness of internal and external developments (scientific, clinical, competitive, and regulatory) that could impact the development plan, including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review - Working as part of a cross-functional team with colleagues from biostatistics, data management, clinical pharmacology, commercial, regulatory and project management You will need to have: - MD, DO, MBBS (or equivalent) degree with relevant clinical speciality for the the therapeutic area - 7+ years clinical research expertise in neurological diseases with pharmaceutical/CRO industry experience in drug development - Excellent written / oral communication skills - Ability to think strategically and translate strategy into tactical plans to drive outcomes - Must be adaptable, able to prioritize and manage time effectively - Willingness to take on new responsibilities and roles - The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. - Willing to travel to scientific meetings We would prefer for you to have: - Specialty and/or practice, or development experience in Neuromuscular disease (gMG especially) - Rare Disease, Gene Therapy and/or Cell therapy experience would be a plus - Board-certified in Neurology would be a plus - Publications (peer-reviewed) and presentation records - Experience preparing documents and attended regulatory meetings with regulatory agencies - Experience designing and completing multinational clinical trials - History of leading cross-functional teams to define clinical strategy and clinical study design - Experience supporting business development activities - Business development experience - Publication in peer-reviewed journals Working at Alexion We’re inspired to think differently, to create better outcomes. By creating an unparalleled employee experience, our organization is equipped to adapt and enrich employees with a productive, engaging, and enjoyable work experience, while accelerating world-class leadership and innovation capabilities that can deliver on our mission. Each of us is accountable for delivering innovative medicines and supportive technology with integrity so we can truly understand and better the lives of people affected by rare diseases. Together, we can transform lives every day The Highest Standards By operating with the highest standards of ethics and integrity, we aspire to live up to the expectations of patients, physicians, and ourselves, and to earn trust in our communities. Diversity We encourage diversity of backgrounds and ideas. We genuinely care for and respect each other, working together as a high-performing team to deliver extraordinary results while embracing different perspectives. Dedication The dedication and passion of our employees enable us to stay focused on what matters most. We push ourselves to achieve the highest level of medical innovation, and to redefine what it means to live with a rare disease. In-Office Hybrid This role has an expectation of working in the office a minimum of 3 days a week. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. Inperson working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. The annual base pay for this position ranges from 280,895.20 to 421,342.80 USD Annual . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Title: Medical Director Clinical Development Hematology Location: US - Boston - MA Full time Job Description: Medical Director, Clinical Development Hematology The Medical Director, Clinical Development may lead the clinical sub-team or support the clinical sub-team and the global program team to build global clinical development plans and contributes to the development of asset level and therapeutic area strategies. Responsible for overseeing the clinical development strategy development and execution for 1 program, leading the clinical subteam to the GPT and represents clinical development on the GPT, contributing to the development of regulatory strategy, and representing the clinical program at regulatory meetings, as assigned by manager. What You Will Do - Lead or support the clinical subteam and oversee the design and execution of multiple clinical studies or clinical programs. - Represent Clinical Development on the Global Program Team (GPT) and in presentations at management and review committees. - Functionally, supervise and develop medical monitors and/or clinical development scientists (CDS), if any and as assigned by the manager. - Lead one or more clinical study teams in the preparation of clinical study related documents including protocols, charters, statistical summary reports, meeting presentations, publications, and clinical sections of regulatory documents, as assigned by manager. - Development of medical content for regulatory document, and responses (including but not limited to NDAs/BLAs, sNDAs/SBLAs, briefing packages and common technical documents - Determine appropriate external experts for advisory boards, steering committees, adjudication committees, and/or data monitoring committees, and lead the team in preparation for meetings. - Critically evaluate available information about diseases of interest to the therapeutic area and the competitive landscape and synthesize information succinctly to support dissemination and incorporation into clinical development programs, asset plans, and therapeutic area strategy. - Serve as the Medical input to the Global Development Team/Subteam and the Medical Expert for clinical study team. - Conduct medical monitoring activities during periods of vacations, team restructuring, team departures or in other situations, as assigned by manager. - Lead the presentation of clinical trial related information/data to senior management, as assigned by manager. - Liaise internally with other members of the clinical development team to drive overall program strategy and development plans. Represent Clinical Development at the Global Program Team. - Maintain awareness of internal and external developments (scientific, clinical, competitive, and regulatory) that could impact the development plan, including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review. - Support business development activities, such as due diligence and research collaborations, as assigned by manager. - May serve as the Translational Science lead for one or more programs, as assigned by manager. - Working as part of a cross-functional team with colleagues representing biostatistics, data management, clinical pharmacology, commercial, regulatory, safety, quality, and project management, or others, as assigned by manager.. - Program Design and Execution, if applicable and as assigned by manager. - Be accountable for the overall integrity of the data in the clinical trial. Who You Are - Physician with MD or foreign equivalent - 3-5 years of clinical development experience preferably within industry - 3-5 years minimum experience as a medical monitor for clinical trials required - Regulatory experience preferred - Track record of publication in peer reviewed journals, preferably first-authored publications - Excellent written / oral communication skills - Attention to detail and ability to think strategically - Willingness to take on new responsibilities - Interest and ability to learn about new therapeutic areas - The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; problem solve; engage in complex and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours We would prefer for you to have - Clinical specialty certification from US or foreign equivalent - Preferred: Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data. - 3+ years of industry experience in clinical development is preferred - Experience for medical responsibilities on a cross-functional team preferred - Formal training (certificate or graduate degree) in epidemiology, clinical trials, clinical research, biostatistics is strongly preferred - Broad experience in the principles of clinical trial methodology, statistics, data analysis and interpretation - Understanding of general (and specific) therapeutic principles - Experience designing and executing industry-sponsored clinical trials - Expert in scientific literature searches and weighing of quality peer reviewed data - Experience authoring study essential documents, Clinical Study Reports, and regulatory documents - Strong relevant therapeutic area experience - Ability to clearly communicate to internal and external stakeholders orally and in writing - Experience interacting with varying levels of internal/external management and/or academicians and/or clinicians and/or scientists, etc. - Strong business acumen: including in-depth knowledge of the multidisciplinary functions involved in a company’s drug development process, e.g., clinical operations, biostatistics, regulatory, commercial operations, etc. and can proactively integrate multiple perspectives into the clinical development process for best end-results - Ability to prioritize multiple tasks and goals to ensure completion in a timely manner within budget - Ability to think both strategically and tactically - Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data Working at Alexion We’re inspired to think differently, to create better outcomes. By creating an unparalleled employee experience, our organization is equipped to adapt and enrich employees with a productive, engaging, and enjoyable work experience, while accelerating world-class leadership and innovation capabilities that can deliver on our mission. Each of us is accountable for delivering innovative medicines and supportive technology with integrity so we can truly understand and better the lives of people affected by rare diseases. Together, we can transform lives every day The Highest Standards By operating with the highest standards of ethics and integrity, we aspire to live up to the expectations of patients, physicians, and ourselves, and to earn trust in our communities. Diversity We encourage diversity of backgrounds and ideas. We genuinely care for and respect each other, working together as a high-performing team to deliver extraordinary results while embracing different perspectives. Dedication The dedication and passion of our employees enable us to stay focused on what matters most. We push ourselves to achieve the highest level of medical innovation, and to redefine what it means to live with a rare disease. In-Office Hybrid This role has an expectation of working in the office a minimum of 3 days a week. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. The annual base pay for this position ranges from 241,613.60 - 362,420.40 USD Annual. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Title: Medical Science Liaison, Rare Hematology, Virginia, Georgia, N. Carolina, S. Carolina Location: Wilmington United States Job Description: This is what you will do: The Medical Science Liaison (MSL) is a field-based scientific expert that strategically supports the medical and scientific objectives of Alexion, AstraZeneca Rare Disease's product/s across the product/s life cycle. The individual is a peer scientific expert who communicates accurate and applicable science to Healthcare Practitioners (HCPs) within a geographic area. The individual manages and maintains collegial and professional relationships with HCPs and Key Opinion Leaders (KOLs) and identifies and facilitates collaboration opportunities with Alexion, AstraZeneca Rare Disease. The MSL combines strong business acumen and clinical expertise and serves as a peer-to-peer liaison internally to Medical Directors, USMA Leadership Team, cross-functional partners and externally (HCPs & KOLs). The MSL should be able to identify problems early on, seek appropriate help and counsel to work past any barriers, and innovate in order to achieve medical goals and objectives. You will be responsible for: HCP relationship management - Evaluates their territory to profile and identify the HCPs to engage and build relationships with, as well as identify, important centers of excellence - Develops clear, succinct, impactful HCP engagement plans, aligned with medical strategic goals and objectives. Evaluates and refines plans as needed per the progress against the quarterly focus priorities - Gains HCPs' trust and respect by effectively providing and communicating relevant scientific/medical information on the company's products and disease states - Gathers and disseminates HCP insights as appropriate internally to help inform medical strategy - Develops strong working relationships in different external business settings Scientific knowledge and training - Keeps current with scientific knowledge within assigned products and therapeutic area - Supports scientific exchange of product/disease state with external stakeholders (HCPs) as needed - Provides relevant scientific information to other internal teams and functions as appropriate - Demonstrates a functional understanding of real-world evidence and HEOR Research & Development - Demonstrates a strong understanding of clinical study design and protocols - Ensures HCPs and stakeholders receive focused and balanced clinical and scientific information - Develops expertise in applicable research outcomes to credibly conduct effective discussion with HCPs - Supports applicable externally sponsored research and clinical trials, as appropriate US Healthcare system knowledge - Acquires knowledge of the current US healthcare system environment and its impact on the rare disease ecosystem - Builds a basic understanding of the foundations of managed markets - Acquires a basic understanding of the flow of information in managed care and government organizations You will need to have: Minimum Education - MD, PharmD, or PhD in biological sciences strongly preferred - Clinical experience in a relevant therapeutic area OR track record of success as an MSL Minimum Experience - Industry experience is preferred but not mandatory; if no industry experience, therapeutic area experience (Hematology/Nephrology/Transplant) is preferred Specific Knowledge, Skills, and Abilities - Has excellent communication skills (oral and written) - Energetically embraces responsibilities and demonstrates the ability to achieve goals - Has a strong personal initiative - Functions well as part of a cross-functional team - Exhibits excellent time management - Able to work independently - Demonstrates leadership skills and high-level job competencies Additional Role Requirements - Office is home based. Travel within region 3-4 days per week with 1-2 office days per week - Person should be able to travel minimum ~70% time - Required travel to medical meetings, team meetings and other group meetings (including possible weekends, as dictated by conference schedule) - Candidate is required to live within the territory - The duties of this role are generally conducted in a field environment. As is typical of a field-based role, employees must be able, with or without an accommodation, to travel by public transportation, automobile, train, or plane; work comfortably in a clinical setting; use a computer; engage in communications via phone, video, and electronic messaging; problem solve; engage in complex and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours - At AstraZeneca, we are taking bold action on climate because we recognize the connection between healthy people and a healthy planet. As part of our flagship Ambition Zero Carbon program, we have committed to a fully electric vehicle (EV) fleet by the end of 2025, which means that all of our drivers will be assigned an EV. Ability to travel within territory on a regular basis which will include frequent overnight and weekend travel. Valid driver's license and clean driving record required). - All activities should be conducted per Alexion, AstraZeneca Rare Disease policies. Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Title: Senior Medical Director Clinical Development Nephrology Location: US - Boston - MA Job Description: Senior Medical Director, Clinical Development Sciences Nephrology The Senior Medical Director, Clinical Development Sciences Nephrology may lead the clinical sub-team or support the clinical sub-team and the global program team to build global clinical development plans and contributes to the development of asset level and therapeutic area strategies. Responsible for overseeing the clinical development strategy development and execution for 1 program, leading the clinical subteam to the GPT and represents clinical development on the GPT, contributing to the development of regulatory strategy, and representing the clinical program at regulatory meetings, as assigned by manager. What You Will Do - Lead or support the clinical subteam and oversee the design and execution of multiple clinical studies or clinical programs. - Represent Clinical Development on the Global Program Team (GPT) and in presentations at management and review committees. - Functionally, supervise and develop medical monitors and/or clinical development scientists (CDS), if any and as assigned by the manager. - Lead one or more clinical study teams in the preparation of clinical study related documents including protocols, charters, statistical summary reports, meeting presentations, publications, and clinical sections of regulatory documents, as assigned by manager. - Development of medical content for regulatory document, and responses (including but not limited to NDAs/BLAs, sNDAs/SBLAs, briefing packages and common technical documents - Determine appropriate external experts for advisory boards, steering committees, adjudication committees, and/or data monitoring committees, and lead the team in preparation for meetings. - Critically evaluate available information about diseases of interest to the therapeutic area and the competitive landscape and synthesize information succinctly to support dissemination and incorporation into clinical development programs, asset plans, and therapeutic area strategy. - Serve as the Medical input to the Global Development Team/Subteam and the Medical Expert for clinical study team. - Conduct medical monitoring activities during periods of vacations, team restructuring, team departures or in other situations, as assigned by manager. - Lead the presentation of clinical trial related information/data to senior management, as assigned by manager. - Liaise internally with other members of the clinical development team to drive overall program strategy and development plans. Represent Clinical Development at the Global Program Team. - Maintain awareness of internal and external developments (scientific, clinical, competitive, and regulatory) that could impact the development plan, including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review. - Support business development activities, such as due diligence and research collaborations, as assigned by manager. - May serve as the Translational Science lead for one or more programs, as assigned by manager. - Working as part of a cross-functional team with colleagues representing biostatistics, data management, clinical pharmacology, commercial, regulatory, safety, quality, and project management, or others, as assigned by manager.. - Lead Pediatric Program Design and Execution, if applicable and as assigned by manager. - Be accountable for the overall integrity of the data in the clinical trial. Who You Are - Physician with MD or foreign equivalent - 5-10 years of clinical development experience preferably within industry - 3-5 years minimum experience as a medical monitor for clinical trials required - Regulatory experience preferred - Track record of publication in peer reviewed journals, preferably first-authored publications - Excellent written / oral communication skills - Attention to detail and ability to think strategically - Willingness to take on new responsibilities - Interest and ability to learn about new therapeutic areas - The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; problem solve; engage in complex and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours We would prefer for you to have - Clinical specialty certification from US or foreign equivalent - Preferred: Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data. - 5+ years of industry experience in clinical development is preferred - Experience for medical responsibilities on a cross-functional team preferred - Formal training (certificate or graduate degree) in epidemiology, clinical trials, clinical research, biostatistics is strongly preferred - Broad experience in the principles of clinical trial methodology, statistics, data analysis and interpretation - Understanding of general (and specific) therapeutic principles - Experience designing and executing industry-sponsored clinical trials - Expert in scientific literature searches and weighing of quality peer reviewed data - Experience authoring study essential documents, Clinical Study Reports, and regulatory documents - Strong relevant therapeutic area experience - Ability to clearly communicate to internal and external stakeholders orally and in writing - Experience interacting with varying levels of internal/external management and/or academicians and/or clinicians and/or scientists, etc. - Strong business acumen: including in-depth knowledge of the multidisciplinary functions involved in a company’s drug development process, e.g., clinical operations, biostatistics, regulatory, commercial operations, etc. and can proactively integrate multiple perspectives into the clinical development process for best end-results - Ability to prioritize multiple tasks and goals to ensure completion in a timely manner within budget - Ability to think both strategically and tactically - Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data At Alexion, you will find a collaborative culture that encourages innovation and a diverse environment where your contributions are valued. You will have the opportunity to be at the forefront of rare disease research and make a meaningful difference in patients' lives. Working at Alexion - We’re inspired to think differently, to create better outcomes. By creating an unparalleled employee experience, our organization is equipped to adapt and enrich employees with a productive, engaging, and enjoyable work experience, while accelerating world-class leadership and innovation capabilities that can deliver on our mission. Each of us is accountable for delivering innovative medicines and supportive technology with integrity so we can truly understand and better the lives of people affected by rare diseases. Together, we can transform lives every day The Highest Standards By operating with the highest standards of ethics and integrity, we aspire to live up to the expectations of patients, physicians, and ourselves, and to earn trust in our communities. Diversity We encourage diversity of backgrounds and ideas. We genuinely care for and respect each other, working together as a high-performing team to deliver extraordinary results while embracing different perspectives. Dedication The dedication and passion of our employees enable us to stay focused on what matters most. We push ourselves to achieve the highest level of medical innovation, and to redefine what it means to live with a rare disease. In-Office Hybrid This role has an expectation of working in the office 3 days a week. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. The annual base pay (or hourly rate of compensation) for this position ranges from $280.895,20 to $421.342,80. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Title: Senior Medical Director, Clinical Development Rare Cardiology Location: US - Boston - MA Job Description: Full time job requisition id R-241823 The Senior Medical Director Clinical Development will lead the clinical team for a high-visibility program and report to the Global Clinical Head. This is an excellent opportunity for an experienced and motivated drug developer to advance an innovative, late-stage study. The SD will provide medical leadership across late stage. Acting as a key medical expert on the study team(s), the SD may also serve as medical monitor as needed. In this role, the SD will work cross-functionally and mentor Physicians, Clinical Directors, and Clinical Development Scientists. The position may include direct and indirect managerial responsibilities for team members across the Clinical Development organization. The SD will also contribute to the development of regulatory, therapeutic area, and functional strategies. This position offers the opportunity to collaborate closely with enterprise-level, cross-functional teams, including AstraZeneca Business Units, CVRM, and strategic development partners. The ideal candidate will thrive in a fast-paced, proactive, and collaborative culture—demonstrating strong communication skills, scientific leadership, and the ability to drive impact across both internal and external teams. You will be responsible for: - Lead cross-functional clinical program teams to deliver high-quality studies and research strategies, ensuring scientific rigor and optimal benefit–risk management. - Serve as the clinical authority for assigned programs, overseeing study design, execution, data interpretation, and regulatory deliverables in compliance with GCP. - Provide strategic medical and scientific input across R&D, translational science, commercial, and business development activities, including due diligence and collaborations. - Mentor and develop Medical Directors, Clinical Development Scientists, and fellows to build organizational scientific and leadership capability. - Represent the program internally and externally through governance presentations, regulatory interactions, scientific publications, and engagement with key opinion leaders. You will need to have: - MD with specialty training in Internal Medicine. - 7+ years of experience in clinical development; clinical research, global regulatory, and product development expertise - Has prepared documents and attended regulatory meetings with FDA and other regulatory agencies. - Experience designing and executing multinational clinical trials required - Demonstrated ability to lead cross-functional teams to define clinical strategy and clinical study design. - Experience supporting business development activities. - Ability to learn rapidly, think critically, and operate effectively in a fast-paced environment. - The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. We would prefer for you to have: - Board Certification. - Experience in ATTR amyloidosis - Preferred: Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data. - PhD in related discipline desirable. - Experience with BLA/MAA submissions. - Demonstrated experience as a clinical trialist with a strong external network, including relationships with key investigators, sites, and patient partners. - Experience operating at the clinical-commercial interface and shaping clinical strategies with commercial insight. - Broad awareness of the global therapeutic landscape and regulatory environment within rare or cardiometabolic diseases. - Willingness and ability to travel nationally and internationally. Working at Alexion We’re inspired to think differently, to create better outcomes. By creating an unparalleled employee experience, our organization is equipped to adapt and enrich employees with a productive, engaging, and enjoyable work experience, while accelerating world-class leadership and innovation capabilities that can deliver on our mission. Each of us is accountable for delivering innovative medicines and supportive technology with integrity so we can truly understand and better the lives of people affected by rare diseases. Together, we can transform lives every day The Highest Standards By operating with the highest standards of ethics and integrity, we aspire to live up to the expectations of patients, physicians, and ourselves, and to earn trust in our communities. Diversity We encourage diversity of backgrounds and ideas. We genuinely care for and respect each other, working together as a high-performing team to deliver extraordinary results while embracing different perspectives. Dedication The dedication and passion of our employees enable us to stay focused on what matters most. We push ourselves to achieve the highest level of medical innovation, and to redefine what it means to live with a rare disease. In-Office Hybrid This role has an expectation of working in the office a minimum of 3 days a week. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. Inperson working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. The annual base pay for this position ranges from 280,895.20 to 421,342.80 USD Annual . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Director, U.S. Federal and State Health Policy and Access, Rare Disease Boston, MA Job Description: Full time job requisition id R-249219 Alexion Corporate Affairs Hybrid Work- on average 3 days a week from office Ability to travel up to 25% This role leads the development and execution of an integrated U.S. health policy strategy aligned with AstraZeneca enterprise priorities to support patient access, advance launch and lifecycle readiness, and enable long-term innovation for Alexion’s rare disease portfolio. The role is integral to the success of the U.S. Commercial organization. You'll sit at the intersection of health policy and regulatory policy, shaping federal and state environments to enable timely and appropriate patient access to innovative therapies, particularly for complex and next-generation treatments, including cell and gene therapies. What you'll do U.S. Health Policy Strategy & Environment Shaping - Lead the development and execution of a comprehensive U.S. federal and state health policy strategy aligned to Alexion’s rare disease portfolio and enterprise priorities. - Shape the external policy environment to support innovation, sustainability, and patient access for rare disease therapies. - Identify and address systemic policy barriers across diagnosis, referral pathways, treatment initiation, and care coordination. - Anticipate and influence policy needs for advanced and next-generation therapies, including cell and gene therapies. - Develop and maintain policy positions that support the long-term growth and sustainability of the rare disease ecosystem. - Lead and coordinate a “one team” Alexion view on policy, impacts, and strategies; serve as the primary Alexion representative in broader AstraZeneca working groups to ensure calibration and unified positions. Policy Integration with Access, Regulatory, and Lifecycle Strategy - Serve as primary health policy partner to Market Access, ensuring federal and state policy considerations are integrated into brand and lifecycle planning. - Translate evolving policy and regulatory dynamics into strategic implications for coverage, reimbursement, and patient access, without direct ownership of access strategy execution. - Partner with Regulatory Affairs to ensure alignment between health policy strategy and regulatory policy priorities, translating regulatory developments into broader policy implications. - Support alignment on integrated policy approaches across FDA, CMS, and state regulators, while respecting functional ownership. - Provide policy input to support launch readiness and lifecycle planning, including identification of risks, opportunities, and mitigation strategies. External Engagement, Advocacy & Stakeholder Leadership - Lead engagement with federal and state policymakers, regulators, and agencies (e.g., CMS, HHS, state Medicaid programs) to shape policies impacting rare disease. - Partner with Federal and State Government Affairs to drive coordinated advocacy strategies, legislative engagement, and policy campaigns. - Lead engagement with trade groups and policy coalitions, and partner with Patient Advocacy, Global Patient Experience, and Medical Affairs teams to support engagement with external stakeholders.. - Support policy approaches that enable provider readiness, diagnostic pathways, and coordinated care for rare disease patients. Strategic Insight, Evidence & Enterprise Alignment - Identify key evidence gaps relevant to policy and access decision-making and partner cross-functionally to inform evidence generation priorities. - Leverage data, real-world evidence, and insights to support policy positioning and external engagement. - Provide actionable policy insights and recommendations to U.S. leadership to inform business strategy and decision-making. - Monitor and assess emerging policy trends, establishing early warning systems and scenario planning for key risks (e.g., IRA, Medicaid, 340B, PBM reforms, and utilization management). - Ensure alignment across Corporate Affairs, Market Access, Regulatory, Medical, and Commercial teams, supporting integrated enterprise positions. Essential for the role - Bachelor’s degree - 8+ years of experience in health policy or government affairs - Pharmaceutical experience in a healthcare policy, reimbursement or market access or, payer experience (CMS, health plan, PBM), or related healthcare policy consulting, law or financial/actuarial firm. - Expertise in U.S. federal and state health policy affecting rare disease or specialty medicines. - Knowledge of Medicare, Medicaid, Marketplace, VA, DoD, 340B and Commercial programs and payer policies, reimbursement processes, and reimbursement coding inclusive of strategy development - Experience engaging external stakeholders and alliances. - Strong strategic, analytical, and communication skills (oral and written). Desirable for the role - Advanced degree (e.g., MBA. JD, MHA, MPH). - Strong knowledge of FDA regulatory frameworks and approval pathways (NDA, BLA, accelerated approval, priority review, REMS, labeling, post marketing commitments). - Experience working in a matrixed organization. - Experience partnering with Market Access and Regulatory Affairs. Office Working Requirements When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. The annual base pay for this position ranges from $166,324.00 - 249,486.00 USD. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. ​ #LI-Hybrid ​ Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics.