Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation. Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs. Description of Role The Director of Medical Affairs Operations will establish and lead the operational function within Medical Affairs. Reporting to the Executive Director, Head of Medical Affairs, this role ensures that Medical Affairs strategies are executed effectively, compliantly, and with operational excellence. The Director will oversee strategic planning, budget and resource management, medical governance, systems and processes, and cross-functional coordination to support the overall success of the Medical Affairs organization. Key Responsibilities - Strategic Operations Leadership: - Partner with the Head of Medical Affairs to define and execute the operational strategy supporting corporate and medical objectives - Build strong partnerships with key cross-functional stakeholders including Compliance, Finance, Clinical Development, Commercial, and Regulatory - Facilitate Medical Affairs functional alignment to ensure efficiency and collaboration - Business Planning & Performance Management: - Collaborate with the Medical Director in leading strategic planning, launch readiness planning, annual operating plans, and long-range forecasts - Develop and manage Medical Affairs operational structure, budgets, resource allocation, and KPIs to track and report performance - Provide insights and recommendations to optimize impact, efficiency, and resource utilization - Manage end-to-end contracting processes with procurement (vendor onboarding, purchase orders, invoicing) - Operational Excellence & Systems: - Drive implementation and continuous improvement of systems, processes, and tools supporting Medical Affairs (e.g., medical information, medical insights, evidence generation, external engagement) - Foster innovation and digital transformation to enhance operational effectiveness - Collaboration: - Act as a trusted partner and operational lead to medical directors, field medical leadership, medical affairs functional leads, and cross-functional stakeholders (R&D, Commercial, Market Access, etc.). - Champion a culture of collaboration, accountability, and performance excellence. Qualifications - Minimum bachelor’s degree or Advanced degree (PhD, PharmD, MBA, MS, or relevant life sciences/business degree preferred). - 10+ years of progressive experience in Medical Affairs Operations, Medical Affairs, Launch Operations, or cross-functional leadership roles - Proven track record in strategic planning, operational leadership, and cross-functional collaboration - Ability to make appropriate decisions to operationalize and move key projects forward - Experience in early-stage medical affairs organizations preferred - Excellent, interpersonal as well as written and verbal communication skills - Highly skilled in influencing without authority, driving alignment, and fostering collaboration across functions and leadership levels. - Strong attention to detail and ability to work independently Compensation The annual base salary range for this level is $190,000.00 to $250,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge. In addition to base pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to share in Centessa’s long-term success. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program. Work Location The Director, Medical Affairs Operations role is a remote role based in the US, with occasional travel. POSITION: Full-Time, Exempt EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.

Why Join Intellia? Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together. Job Summary As the Medical Affairs Senior Medical Director for the lonvoguran ziclumeran (lonvo-z or NTLA-2002) hereditary angioedema program, you will embrace the challenge to create an innovative US and global Medical Affairs approach to support the launch of lonvo-z. This individual has a history of clinical and pharmaceutical industry experience, ideally in the fields of immunology, allergy, or rare diseases, with expertise in hereditary angioedema being strongly preferred. This role has four primary focus areas: KOL Engagement Strategy - Leading the development and execution of comprehensive thought leader engagement Real-world Evidence Generation - Partnering with HEOR on real-world evidence generation to develop and execute post-marketing integrated evidence plan Internal SME & Training - Serving as the in-house subject matter expert for educational initiatives Healthcare systems Strategy – Partnering with the commercial and access team on ensuring access and accessibility in the post-marketing setting The candidate will have strong experience in product launches, including proven ability to translate and appropriately align commercial and medical goals and objectives. Primary Duties/Responsibilities KOL Engagement Strategy (20%) - Develop and drive strategic engagement plan with key stakeholders identified as strategic partners, including medical societies, payers, and provider groups as well as medical experts in hereditary angioedema, especially in the United States - Develop relationships and drive interactions with investigators, KOLs, research institutions, and centers of excellence to oversee and support the HAE Medical Affairs plan objectives - Work closely with Patient Advocacy, Medical Engagement and Regional Scientific Directors to develop and execute medical engagement strategy - Play an integral role in planning and executing national and regional medical advisory boards with the HAE community - Identify, map, and prioritize thought leaders across relevant geographies to engage as a global medical director strategic team, as well as identifying relevant thought leaders based on special interest topics such as research, special populations. Real-world Evidence Generation (30%) - Collaborate with other line functions (Clinical Development, HEOR) to ensure that the integrated evidence generation plan is aligned with the lonvo-z HAE program objectives - Provide medical support to the design and execution of research / translational analyses, clinical trial post-hoc analyses, post-marketing studies, real-world studies, and claims analyses - Work closely with Access & HEOR to support key educational, engagement and evidence generation initiatives - Partner on the development of real-world evidence strategies, including registry design and observational research - Design and execute the investigator-led research program - Provide medical expertise to support health economic modeling and value proposition development - Contribute to evidence dossiers for payers and policy makers Internal Subject Matter Expert & Training Leadership (20%) - Serve as the primary in-house medical affairs subject matter expert on hereditary angioedema, CRISPR technology, and lonvo-z, including completing medical/legal/review for commercial materials, as needed (cMLR committee) - Deliver training programs for medical affairs, commercial, and market access teams - Responsible for the medical accuracy and fair balance of medical information in educational and other medical communication and learning materials designed for an HCP audience - Contribute to scientific resources, including disease overviews, competitive landscape analyses, and clinical data summaries - Provide on-demand scientific consultation to cross-functional stakeholders - Develop content and present at internal and external medical education programs as needed Healthcare systems Strategy (20%) - Serve as the primary in-house medical affairs subject matter expert on lonvo-z systems obligations and competencies - Contribute to a cross-functional team to prepare for post-marketing accessibility of lonvo-z, including prescriber and system readiness - Design and execute an evidence generation plan that enables an understanding of the impact of a one-time treatment on overall healthcare system costs and burden together with Access/HEOR Additional Responsibilities (10%) - Support the Medical Affairs Lead for lonvo-z in the development of short-term and long-term strategy, as well as execution of the program medical affairs plan as a key component of the integrated brand plan - Participate in the Medical Access Commercialization team for HAE, together and in close partnership with the Medical Affairs Lead and Program Brand Lead - Collaborate with the Scientific Communications team supporting the review and approval of publications and resources ensuring medical accuracy and alignment of all communication materials - Provide medical input into the safety profile of the product in collaboration with Clinical Development and Patient Safety colleagues Requirements Skills/Abilities - Robust clinical research experience within the pharmaceutical/biotech industry - Previous experience within a medical affairs team with responsibility for late-stage clinical studies across multiple regions - Strong track record in KOL engagement strategy development and execution - Demonstrated experience leading and executing evidence generation initiatives - Proven ability to serve as SME and deliver impactful training programs - Solid communication, strategic, interpersonal, and negotiating skills, with ability to proactively predict challenges and solve problems - Ability to drive decision-making within multi-disciplinary, multi-regional, matrix teams - Diplomacy and positive influencing abilities - Knowledge of both regional and global Regulatory requirements - Demonstrated ability to present complex issues to management and contribute to executive level presentations and discussions - Experience leading and motivating cross-functional teams and vendors/consultants - Excellent interpersonal skills with an ability to respond to multiple external and internal queries, managing and handling conflict constructively - Success working in a fast paced, matrixed, growing organization, partnering with multiple internal & external stakeholders Job Education / Certifications - MD/PharmD Experience - At least 7-10 years experience in Medical Affairs and Clinical Development in the biotechnology/pharmaceutical industry - Experience in Medical Affairs leadership for products addressing rare diseases, with strong therapeutic area knowledge in hereditary angioedema, immunology, or related fields - Experience with novel modalities (gene editing, CRISPR, genetic medicines) strongly preferred - Track record of successful research in therapeutic areas relevant to Intellia's development programs and pipeline Physical Requirements - Ability to sit or stand for multiple hours at a computer - Manual dexterity for keyboarding; may include repetitive movements - Travel up to 40-50% for KOL meetings, conferences, and internal training sessions #LI-Remote EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down. The base salary for this position is expected to range between $295,965.00 - $361,735.00 USD per year.The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors. Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company’s discretion. For more information about Intellia’s benefits, please click here.

Why Join Intellia? Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together. As the Medical Affairs Senior Medical Director for the NTLA-2001 ATTR amyloid polyneuropathy program, you embrace the challenge to create an innovative US and global Medical Affairs approach to support Intellia’s CRISPR/cas9 programs. This individual has a history of clinical and pharmaceutical industry experience, ideally in the fields of neuropathic disorders, with a specialty in neurology being preferred. The candidate will also have strong experience in product launches, including proven ability to translate and appropriately align commercial and medical goals and objectives. This role will be responsible for developing and leading medical affairs plans in close collaboration with cross-functional teams, contributing to clinical strategy, collaborating to develop impactful medical education, evidence generation and healthcare system and key stakeholders engagement plans. In addition, the Senior Medical Director for the NTLA-2001 ATTR amyloid polyneuropathy program will be accountable for operational oversight of execution of the plans. Duties/Responsibilities - Medical Affairs Product Lead for NTLA-2001 ATTR-PN, our lead investigational therapy for the treatment of transthyretin amyloidosis in patients with polyneuropathy, in the development of short-term and long-term strategy, as well as execution of the program medical affairs plan as a key component of the integrated brand plan and in full support of the key strategic imperatives - Lead the Medical Access Commercial subteam for NTLA-2001 ATTR-PN, together and in close partnership with the Medical Affairs Lead and Program Brand Lead - Responsible for the alignment of all global medical affairs activities in close partnership with other members of the Medical Access Commercial subteam and Program Leadership Team - Responsible for the medical accuracy and fair balance of medical information in educational and other medical communication and learning materials for both internal and external use. - Collaborate with other line functions (Clinical Development, HEOR, etc.) to ensure that the medical evidence generation plan is aligned with the NTLA-2001 ATTR-PN program objectives - Develop and drive strategic engagement plan with stakeholders identified as strategic partners, including advocacy groups, medical societies, payers, and provider groups as well as medical experts in ATTR amyloid polyneuropathy, especially in the United States - Work closely with Patient Advocacy, Medical Engagement and Regional Scientific Directors to develop and execute medical engagement strategy - Plan and execute on holding of national and regional medical advisory boards with the ATTR-PN community - Provide medical input into the safety profile of the product in collaboration with Clinical Development and Patient Safety (PS) colleagues - Collaborate with all Medical Affairs functions and work closely with Access & HEOR to support key educational, engagement and evidence generation initiatives - Provide clinical support to the design and execution of HEOR studies, outcomes surveys, etc. in close collaboration with HEOR/Access colleagues - Work closely with Clinical Development team to ensure optimal collaboration and inclusion of external clinicians/KOLs and other relevant healthcare system stakeholders in clinical trial planning, enrollment, and interpretation - Develop relationships and drive interactions with investigators, KOLs, research institutions, and centers of excellence to oversee and support the ATTR-PN Medical Affairs plan - Collaborate with the Scientific Communications team supporting the review and approval of publications and resources ensuring medical accuracy and alignment of all communication materials - Lead Intellia Medical Affairs initiatives at key congress meetings and conferences, including content development and presentation for internal and external medical education programs as needed Supervisory Responsibilities ☐ N/A Requirements Skills/Abilities - Robust clinical research experience within the pharmaceutical/biotech industry - Previous experience leading a medical affairs/clinical development team with responsibility for late-stage clinical studies across multiple regions - Solid communication, strategic, interpersonal, and negotiating skills, with ability to proactively predict challenges and solve problems - Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams - Diplomacy and positive influencing abilities - Knowledge of both regional and global Regulatory requirements - Track record of successful and emerging research in therapeutic areas relevant to Intellia’s development programs and pipeline - Demonstrated ability to present complex issues to management and contribute to executive level presentations and discussions - Experience leading and motivating cross-functional teams and vendors/consultants - Excellent interpersonal skills with an ability to respond to multiple external and internal queries, managing and handling conflict constructively - Success working in a fast paced, matrixed, growing organization, partnering with multiple internal & external stakeholders Education / Certifications MD/PharmD Experience At least 10 years experience in Medical Affairs and Clinical Development in the biotechnology/pharmaceutical industry Experience in Medical Affairs leadership for products addressing rare diseases, with strong therapeutic area knowledge relevant to mechanism of action of NTLA-2001. Physical Requirements Ability to sit or stand for multiple hours at a computer Manual dexterity for keyboarding; may include repetitive movements #LI-Remote EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down. The base salary for this position is expected to range between $295,965.00 - $361,735.00 USD per year.The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors. Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company’s discretion. For more information about Intellia’s benefits, please click here.

Overview The Medical Policy Director (MPD) is a key member of the Go To Market team. Along with the Client Engagement Leader, Client Medical Director (CMD), the MPD co-captains the team serving the Prospective Payment Management (PPM) client team at the health plan. The MPDs role is to serve as a coding and medical payment policy subject matter expert (SME), with the assistance of a CMD. The MPD is responsible for directing the Medical Policy Committee (joint committee with health plan MD, coding experts, and payment integrity). The MPD will develop a relationship with the client, review their data, select medical policy to present, serve as SME for clinical and coding expertise, and back-end support for Cotiviti’s and the client’s Medical Directors. The MPD will evolve as the trusted advisor for the Health Plan in terms of medical payment policy. Responsibilities - Act as a knowledgebase expert regarding the Cotiviti Medical Policy library. - Gain an understanding of each client’s unique lines of business, medical policy standards and system configuration strategy to inform optimization opportunities. - Analyze client data and identify new medical policy opportunities for presentation including valuation and validation of editing. - Examine and select specific claim examples to utilize in a presentation to the client to support the understanding of the new medical policy. - Prepare various documents and presentation materials for use during internal payment policy committee meetings and/or client meetings. - Review all documents and coordinate reviews with the CMD to evaluate and validate the editing and financial impact. - Confidently perform client policy presentations to highlight the facts of each rule, the data that supports the policy recommendation, the impact to claims processing, and the associated value. - Successfully advocate for the adoption of new medical policies by clients to optimize the value Cotiviti offers. - Participate in client meetings as required as a medical policy subject matter expert. - Coordinate with the internal client team to ensure that all requested follow-up items are delivered to the client. - Inspire trust and credibility with clients. - Communicate effectively across various organizational levels and members of the internal and external client teams. - Assist in identifying opportunities for other Cotiviti product solutions. - Complete all responsibilities as outlined in the annual performance review and/or goal setting. - Complete all special projects and other duties as assigned. - Must be able to perform duties with or without reasonable accommodation. This job description is intended to describe the general nature and level of work being performed and is not to be construed as an exhaustive list of responsibilities, duties and skills required. This job description does not constitute an employment agreement and is subject to change as the needs of Cotiviti and the requirements of the job change. Qualifications - Bachelor’s Degree in a relevant field or equivalent. - Professional coder certification required (CPC, CPC-A, CCA, CCS, or CCS-P), RHIT or RHIA certification a plus. - Minimum of 7-10 years of work experience, preferably in sales, customer service or client management. - Minimum of 5 years of experience in claim payment adjudication, medical payment/policy editing applying Medicare, Medicaid, ICD, CPT, HCPCS and other specialty society guidelines preferred. - Health plan, managed care or health insurance experience preferred. - Exceptional presentation, interpersonal, verbal and written communication skills. - Superior organizational skills with the ability to work in a fast-faced environment, prioritize, and manage multiple competing deadlines with minimal direction. - Strong problem-solving skills and an ability to think strategically. - Ability to analyze complex data and synthesize it for general consumption. - Demonstrated strategy and analytical thinking skills, with the ability to effectively communicate conclusions and recommendations to diverse audiences. - Excellent computer skills in Microsoft Word, Excel, PowerPoint, and Outlook are a must. - Willingness/availability to travel 10-20% is required. Mental Requirements: - Communicating with others to exchange information. - Assessing the accuracy, neatness, and thoroughness of the work assigned. - Ability to work with a high volume of transactions in a timely manner and meet deadlines. - Must be able to perform daily functions with little or no direct supervision. Working Conditions and Physical Requirements: - This remote role can be located anywhere in the continental US. - Remaining in a stationary position, often standing or sitting for prolonged periods. - Must be able to perform duties with or without reasonable accommodation. - Must be able to provide a dedicated, secure work area. - Must be able to provide high-speed internet access/connectivity and office setup and maintenance. - No adverse environmental conditions are expected. Base compensation ranges from $120,000 to $145,000 per year. Specific offers are determined by various factors, such as experience, education, skills, certifications, and other business needs. This role is eligible for discretionary bonus consideration. Cotiviti offers team members a competitive benefits package to address a wide range of personal and family needs, including medical, dental, vision, disability, and life insurance coverage, 401(k) savings plans, paid family leave, 9 paid holidays per year, and 17-27 days of Paid Time Off (PTO) per year, depending on specific level and length of service with Cotiviti. For information about our benefits package, please refer to our Careers page. Date of posting: 3/6/2026 Applications are assessed on a rolling basis. We anticipate that the application window will close on 5/6/2026, but the application window may change depending on the volume of applications received or close immediately if a qualified candidate is selected. #LI-JB1 #LI-Remote #senior