Krystal Biotech, Inc.

• Support achievement of sales objectives within the assigned region through effective promotion of Vyjuvek to pediatric dermatologists and other key stakeholders involved in the diagnosis, management, and treatment of DEB • Execute territory strategies focused on market development, brand awareness, and patient identification through appropriate, HCP-driven initiatives • Promote and educate healthcare professionals on the indication, usage, safety, and efficacy of Vyjuvek through in-person and virtual meetings, presentations, and educational interactions • Effectively prioritize and manage time, travel, activities, and resources to optimize access to academic and community-based healthcare professionals • Build and maintain consultative sales relationships and ensure consistent, professional communication with customers and prospects • Collaborate cross-functionally with internal stakeholders and other commercial partners to support access and coordination at sites of care • Utilize data, insights, and CRM tools to identify opportunities, prioritize accounts, and support informed territory execution • Develop and implement a territory business plan aligned with regional goals and launch objectives • Responsibly manage company resources, including in-office education (IOE) budgets, promotional materials, and patient-facing materials • Foster teamwork and proactive communication to ensure alignment and coordination with peers across the field organization • Demonstrate Krystal’s corporate values through adherence to company policies, guidelines, and mission • Maintain administrative requirements associated with territory management, including CRM documentation, expense reporting, business planning, and performance review • Attend national, regional, and local meetings and conferences as assigned • Perform other duties as assigned

• Define and implement solutions to improve the patient journey in line with company strategy, e.g. disease awareness • Engage in long-term partnerships with key stakeholders to bring value to the entire EB ecosystem • Ensure the proper administration of the drug by training respective HCPs • Identify breakpoints in the care pathway in order to prioritize and develop the most relevant actions based on the defined strategy. • Establish label-based product related knowledge with HCPs and KEEs at Reference and Competence Centres as well as with office-based HCPs • Execute product and disease related programs, exhibits across reference centres, priority institutions, congresses and events • Train pharmacies & nurses for the preparation and administration as per label to ensure best in class home administration • Achieve sales goals in the assigned territory through promotion of B-VECTM to the HCPs involved in the diagnosis, management and treatment of DEB • Develop and own territory account plans leveraging appropriate internal stakeholders • Collaborate with internal stakeholders to ensure access to care and availability of all necessary logistics to provide drug administration and build EB network and patient support awareness • Generate evidence and insights related to patients’ journey

• Build and maintain excellent relationships with Key Opinion Leaders (KOLs) and medical teams at the treatment centres. • Be a visible and active member of the medical community to raise awareness of Krystal Biotech and the specific novel gene therapy treatments it is bringing to underserved patients. • Be the scientific referent for local patient advocacy groups (upon request). • Support the building of the country medical infrastructures and capabilities. • Actively participate in the country leadership team bringing your medical expertise to frame better decisions. • Effectively present externally at scientific conferences and to high-level scientific or business audiences. • Input into medical affairs strategy for B-VEC or other Krystal Biotech products within the assigned country or region. • Contribute to the scientific communication strategy with key focus in implementing the medical communication and publication national plans. • Contribute to the evidence generation plan (beyond Phase II and III clinical studies), with special focus at national level, including adequate follow-up of all unsolicited investigator-initiated studies proposals and support to all potential Krystal Biotech sponsored late-phase research projects. • Scientifically educate on the correct use of B-VEC and other Krystal Biotech products according to approved labels. • Drive the organization and implementation of Local and/or Regional Advisory Boards and other scientific meetings. • Interpret scientific data from the literature and/or from clinical studies. • Partner with the market access, marketing, and commercial teams, including providing adequate ongoing scientific training in disease and product related areas. • Actively participate in the creation and/or review of the reimbursement dossiers and any associated discussions with external stakeholders, in close partnership with the market access team. • Address adequately all unsolicited medical questions according with all applicable regulations and internal policies. • Support all pharmacovigilance activities, namely reporting and following up adequately and according with all applicable regulations for any reported adverse event. • Review all medical and promotional materials to be used at national level, to ensure the accuracy of information and compliance with all applicable laws and regulations. • Ensure compliance with both the letter and spirit of all laws and regulations. • Remain alert to any potential compliance issues that may arise, seeking counsel through proper channels if such issues are identified.

• Support achievement of sales objectives within the assigned region through effective promotion of Vyjuvek to pediatric dermatologists and other key stakeholders involved in the diagnosis, management, and treatment of DEB • Execute territory strategies focused on market development, brand awareness, and patient identification through appropriate, HCP-driven initiatives • Promote and educate healthcare professionals on the indication, usage, safety, and efficacy of Vyjuvek through in-person and virtual meetings, presentations, and educational interactions • Effectively prioritize and manage time, travel, activities, and resources to optimize access to academic and community-based healthcare professionals • Build and maintain consultative sales relationships and ensure consistent, professional communication with customers and prospects • Collaborate cross-functionally with internal stakeholders and other commercial partners to support access and coordination at sites of care • Utilize data, insights, and CRM tools to identify opportunities, prioritize accounts, and support informed territory execution • Develop and implement a territory business plan aligned with regional goals and launch objectives • Responsibly manage company resources, including in-office education (IOE) budgets, promotional materials, and patient-facing materials • Foster teamwork and proactive communication to ensure alignment and coordination with peers across the field organization • Demonstrate Krystal’s corporate values through adherence to company policies, guidelines, and mission • Maintain administrative requirements associated with territory management, including CRM documentation, expense reporting, business planning, and performance review • Attend national, regional, and local meetings and conferences as assigned • Perform other duties as assigned

• Achieve/exceed sales goals in the assigned territory through promotion of Vyjuvek to pediatric dermatologists and other key stakeholders involved in the diagnosis, management and treatment of DEB • Drive patient identification through appropriate HCP driven strategies including market development, increase brand awareness through building and executing a territory strategy/account plan; continuously assess opportunities within markets and accounts to launch successfully • Promote and educate healthcare professionals on the indication, usage, specifications, safety and efficacy of Vyjuvek through meetings, presentations, and other appropriate means. • Effectively prioritize and manage time, activities, and resources in order to optimize access to academic and community HCPs • Build consultative sales relationships and maintain effective communication with key customers and prospects • Collaborate with internal stakeholders across all commercial departments including patient services, field reimbursement, and others to ensure access at site of care and that logistics are in place to administer medications • Intelligently use and organize data to prioritize opportunities • Develop and implement a strategic territory business plan to exceed goals • Responsibly manage and utilize company resources, including IOE (in-office education) budget, company literature/marketing materials, and patient materials • Foster teamwork and proactive, open communication, ensuring coordination of promotional efforts with peers • Execute speaker programs, local sponsorships, displays and exhibits, both in and out of office across multiple account types: academic institutions, physician offices, infusion centers, and alternate site locations • Demonstrate corporate values by adhering to corporate policies, guidelines and mission. • Maintain and manage administrative requirements of managing a territory, including business planning, recording activities in CRM system, expense reporting and review of territory performance • Attend company meetings and conferences (national, regional and local) as needed/assigned.

• Achieve/exceed sales goals in the assigned territory through promotion of Vyjuvek to pediatric dermatologists and other key stakeholders involved in the diagnosis, management and treatment of DEB • Drive patient identification through appropriate HCP driven strategies including market development, increase brand awareness through building and executing a territory strategy/account plan; continuously assess opportunities within markets and accounts to launch successfully • Promote and educate healthcare professionals on the indication, usage, specifications, safety and efficacy of Vyjuvek through meetings, presentations, and other appropriate means. • Effectively prioritize and manage time, activities, and resources in order to optimize access to academic and community HCPs • Build consultative sales relationships and maintain effective communication with key customers and prospects • Collaborate with internal stakeholders across all commercial departments including patient services, field reimbursement, and others to ensure access at site of care and that logistics are in place to administer medications • Intelligently use and organize data to prioritize opportunities • Develop and implement a strategic territory business plan to exceed goals • Responsibly manage and utilize company resources, including IOE (in-office education) budget, company literature/marketing materials, and patient materials • Foster teamwork and proactive, open communication, ensuring coordination of promotional efforts with peers • Execute speaker programs, local sponsorships, displays and exhibits, both in and out of office across multiple account types: academic institutions, physician offices, infusion centers, and alternate site locations • Demonstrate corporate values by adhering to corporate policies, guidelines and mission. • Maintain and manage administrative requirements of managing a territory, including business planning, recording activities in CRM system, expense reporting and review of territory performance • Attend company meetings and conferences (national, regional and local) as needed/assigned. • Other duties as assigned

• Support achievement of sales objectives within the assigned region through effective promotion of Vyjuvek to pediatric dermatologists and other key stakeholders involved in the diagnosis, management, and treatment of DEB • Execute territory strategies focused on market development, brand awareness, and patient identification through appropriate, HCP-driven initiatives • Promote and educate healthcare professionals on the indication, usage, safety, and efficacy of Vyjuvek through in-person and virtual meetings, presentations, and educational interactions • Effectively prioritize and manage time, travel, activities, and resources to optimize access to academic and community-based healthcare professionals • Build and maintain consultative sales relationships and ensure consistent, professional communication with customers and prospects • Collaborate cross-functionally with internal stakeholders and other commercial partners to support access and coordination at sites of care • Utilize data, insights, and CRM tools to identify opportunities, prioritize accounts, and support informed territory execution • Develop and implement a territory business plan aligned with regional goals and launch objectives • Responsibly manage company resources, including in-office education (IOE) budgets, promotional materials, and patient-facing materials • Foster teamwork and proactive communication to ensure alignment and coordination with peers across the field organization • Demonstrate Krystal’s corporate values through adherence to company policies, guidelines, and mission • Maintain administrative requirements associated with territory management, including CRM documentation, expense reporting, business planning, and performance review • Attend national, regional, and local meetings and conferences as assigned • Perform other duties as assigned