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• Establish and lead the medical information function, including strategy, processes, and execution • Establish scalable medical information infrastructure, including inquiry intake, documentation, and response workflows • Oversee the implementation and training of the medical inquiry intake portal and call center vendors and manage relationships going forward • Develop high-quality medical information response documents (standard response letters, FAQs, backgrounders) and maintain medical information content aligned with product labeling, clinical data, and evolving scientific evidence • Lead and oversee Medical, Legal, and Regulatory (MLR) review • Ensure responses are scientifically accurate, balanced, up-to-date, and compliant with regulation • Ensure appropriate escalation and coordination of safety, quality, and off-label inquiries • Analyze inquiry trends to identify knowledge gaps, unmet medical needs, and opportunities to inform medical strategy • Monitor metrics and quality indicators to ensure continuous improvement and compliance

• Build field reporting and analytics capabilities from the ground up to support KAM performance and decision-making. • Partner with field leadership to define KPIs and develop analytics and dashboards to track performance and impact. • Design and lead a Quarterly Business Review (QBR) process to assess commercial effectiveness and outcomes. • Spend time in the field to understand Dyne’s operating model and translate insights into practical, field-ready solutions. • Own KAM performance analytics and execution in support of incentive compensation programs. • Collaborate with the KAM team to design and implement an account planning tool. • Develop regional and account-level performance dashboards. • Recommend and drive enhancements to BI and CRM tools to improve KAM effectiveness. • Serve as the primary point of contact for the VP, Customer Experience, KAM leadership, and the KAM field team. • Lead field force sizing and structural planning for upcoming launches and ongoing strategic reviews. • Establish and maintain territory alignment and adjustment processes. • Lead account and HCP targeting strategy and analytics in partnership with the Data and Advanced Analytics teams. • Optimize field enablement tools, materials, and processes to maximize field productivity.

• Lead and develop high-performing Field Reimbursement Managers and Nurse Case Managers • Oversee the comprehensive field-based Nurse Case Management and Access Program for Dyne • Foster a coaching culture that enables deeper connection with patients, caregivers, and HCPs. • Set the tone and culture of the team, role model Dyne patient and caregiver, and HCP engagement expectations • Cultivate a “One Dyne” mindset that prioritizes transparency, shared ownership and accountability, where the success of cross-collaborative field team is central to the success of the individual team. • Develop and execute a national plan that is strategically aligned with the overall US Market Access and Patient Services objectives and enables execution of regional business goals in partnership with other Field Leadership. • Manage hiring, onboarding, communication, performance, training and professional development across the team. • Collaborate with internal cross functional partners and external partners (specialty infusion providers, patient support services program) to ensure ongoing support to patients, and their families / caregivers and HCPs. • Develop and maintain strong relationships with HCPs involved with DYNE-251 therapy. • Ensure team expertise in insurance coverage, reimbursement, PA processes, and payer landscapes. • Drive problem-solving to resolve access barriers for patients, caregivers, and HCPs. • Deliver execution plans and manage KPIs supporting post-prescribing performance. • Identify and mitigate risks while ensuring compliance with Dyne policies. • Maintain deep understanding of DMD treatment journeys and adjust tactics accordingly. • Maintain knowledge of rare disease payer policies, including Medicaid.

• Establish and lead the tactical execution of marketing operations focusing on launch readiness • Build the systems, processes, and operational infrastructure for compliant and impactful therapeutic education • Serve as a key partner across multiple departments driving operational excellence • Design and implement a peer-to-peer engagement model for HCPs and consumers • Lead planning and execution of US HCP and consumer-facing congresses and events

• Develop and nurture strong Dyne Therapeutics – Clinical Trial Site relationships • Optimize site performance, particularly enrollment • Oversee CRO site management and monitoring activities • Build/support site relationships while ensuring quality monitoring oversight and delivery of data of high integrity • Work directly with internal study teams, CRO partners, and clinical trial sites